S100 Family: 2.80.10.50.1.1.1.1

Representative domain: 1rg8A00

Classification Lineage (2.80.10.50.1.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.80	Trefoil
2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
2.80.10.50		Gene3D
2.80.10.50.1
2.80.10.50.1.1
2.80.10.50.1.1.1
2.80.10.50.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	10

Non-Redundant Representatives (10)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.80.10.50.1.1.1.1 (10)

CATH code	Domain ID	Keywords
2.80.10.50.1.1.1.1.1	1rg8A00	S100 alpha binding, Regulation of actin cytoskeleton, Pathways in cancer, cellular response to heat, MAPK signaling pathway, Melanoma, growth factor activity, fibroblast growth factor receptor signaling pathway, Homo sapiens, fibroblast growth factor receptor binding, Heparin-binding growth factor 1, fibroblast growth factor, cytosol
2.80.10.50.1.1.1.1.2	1rg8B00	Regulation of actin cytoskeleton, Pathways in cancer, S100 alpha binding, MAPK signaling pathway, cellular response to heat, fibroblast growth factor receptor signaling pathway, growth factor activity, Melanoma, fibroblast growth factor receptor binding, Homo sapiens, Heparin-binding growth factor 1, fibroblast growth factor, cytosol
2.80.10.50.1.1.1.1.3	1jqzA00	fibroblast growth factor, cytosol, Heparin-binding growth factor 1, growth factor activity, Melanoma, fibroblast growth factor receptor signaling pathway, Homo sapiens, fibroblast growth factor receptor binding, Pathways in cancer, Regulation of actin cytoskeleton, S100 alpha binding, cellular response to heat, MAPK signaling pathway
2.80.10.50.1.1.1.1.4	1jqzB00	fibroblast growth factor, cytosol, Heparin-binding growth factor 1, fibroblast growth factor receptor signaling pathway, Melanoma, growth factor activity, fibroblast growth factor receptor binding, Homo sapiens, S100 alpha binding, Regulation of actin cytoskeleton, Pathways in cancer, MAPK signaling pathway, cellular response to heat
2.80.10.50.1.1.1.1.5	1z2vA00	Heparin-binding growth factor 1, cytosol, fibroblast growth factor, MAPK signaling pathway, cellular response to heat, Pathways in cancer, Regulation of actin cytoskeleton, S100 alpha binding, fibroblast growth factor receptor binding, Homo sapiens, fibroblast growth factor receptor signaling pathway, growth factor activity, Melanoma
2.80.10.50.1.1.1.1.6	1z2vB00	fibroblast growth factor, cytosol, Heparin-binding growth factor 1, fibroblast growth factor receptor signaling pathway, Melanoma, growth factor activity, fibroblast growth factor receptor binding, Homo sapiens, S100 alpha binding, Pathways in cancer, Regulation of actin cytoskeleton, MAPK signaling pathway, cellular response to heat
2.80.10.50.1.1.1.1.7	1z4sB00	fibroblast growth factor receptor binding, Homo sapiens, fibroblast growth factor receptor signaling pathway, Melanoma, growth factor activity, MAPK signaling pathway, cellular response to heat, S100 alpha binding, Regulation of actin cytoskeleton, Pathways in cancer, cytosol, fibroblast growth factor, Heparin-binding growth factor 1
2.80.10.50.1.1.1.1.8	1z4sC00	Pathways in cancer, Regulation of actin cytoskeleton, S100 alpha binding, cellular response to heat, MAPK signaling pathway, growth factor activity, Melanoma, fibroblast growth factor receptor signaling pathway, Homo sapiens, fibroblast growth factor receptor binding, Heparin-binding growth factor 1, fibroblast growth factor, cytosol
2.80.10.50.1.1.1.1.9	1z4sA00	cytosol, fibroblast growth factor, Heparin-binding growth factor 1, fibroblast growth factor receptor binding, Homo sapiens, fibroblast growth factor receptor signaling pathway, Melanoma, growth factor activity, MAPK signaling pathway, cellular response to heat, S100 alpha binding, Pathways in cancer, Regulation of actin cytoskeleton
2.80.10.50.1.1.1.1.10	1z4sD00	MAPK signaling pathway, cellular response to heat, Pathways in cancer, Regulation of actin cytoskeleton, S100 alpha binding, fibroblast growth factor receptor binding, Homo sapiens, fibroblast growth factor receptor signaling pathway, growth factor activity, Melanoma, Heparin-binding growth factor 1, cytosol, fibroblast growth factor

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.80.10.50.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.80.10.50.1.1.1.1

Classification Lineage (2.80.10.50.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.80.10.50.1.1.1.1 (10)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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