S95 Family: 2.80.10.50.1.1.1

Representative domain: 1rg8A00

Classification Lineage (2.80.10.50.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.80	Trefoil
2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
2.80.10.50		Gene3D
2.80.10.50.1
2.80.10.50.1.1
2.80.10.50.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	43	100

Non-Redundant Representatives (43)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Family Entries in S95 Family 2.80.10.50.1.1.1 (43)

CATH code	Representative Domain	Representative Keywords	Number of Domains
2.80.10.50.1.1.1.1	1rg8A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	10
2.80.10.50.1.1.1.2	3bb2A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.3	3baoB00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.4	1p63B00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.5	3ba7A00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.6	3bauA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.7	3bavA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.8	3bahB00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.9	1jtcA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	4
2.80.10.50.1.1.1.10	3ba5A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.11	3bagA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.12	3b9uA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	1
2.80.10.50.1.1.1.13	1jt4A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.14	3ba4A00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.15	1q04A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.16	3baqA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.17	3cqaB00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.18	1jt5A00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.19	2aqzB00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.20	3crgA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.21	3fjfB00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.22	3fj9A00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.23	3fjdA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.24	3fjhA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.25	3fjjA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.26	1jt3A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.27	3fjaA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.28	1pzzB00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.29	3fj8A00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.30	3fjcA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.31	3fjbA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.32	2q9xA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	1
2.80.10.50.1.1.1.33	3halA00	Fibroblast growth factor 1 isoform 1 (Predicted)Oryctolagus cuniculus	2
2.80.10.50.1.1.1.34	1q03A00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.35	3criB00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.36	1ytoB00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	4
2.80.10.50.1.1.1.37	3fjeA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.38	3crhA00	Pathways in cancerFibroblast growth factor receptor bindingHeparin-binding growth factor 1S100 alpha bindingCytosol	2
2.80.10.50.1.1.1.39	3fjkA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	6
2.80.10.50.1.1.1.40	3badA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.41	1k5uA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	3
2.80.10.50.1.1.1.42	1k5vA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	2
2.80.10.50.1.1.1.43	1rmlA00	Pathways in cancerHeparin-binding growth factor 1Fibroblast growth factor receptor bindingS100 alpha bindingCytosol	1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.80.10.50.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S95 Family: 2.80.10.50.1.1.1

Classification Lineage (2.80.10.50.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Family Entries in S95 Family 2.80.10.50.1.1.1 (43)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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