S95 Family: 2.70.98.10.2.1.1

Representative domain: 1jz8A05

Classification Lineage (2.70.98.10.2.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.70	Distorted Sandwich
2.70.98	Beta-galactosidase; Chain A, domain 5
2.70.98.10		Gene3D
2.70.98.10.2
2.70.98.10.2.1
2.70.98.10.2.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	50	172

Non-Redundant Representatives (50)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Family Entries in S95 Family 2.70.98.10.2.1.1 (50)

CATH code	Representative Domain	Representative Keywords	Number of Domains
2.70.98.10.2.1.1.1	1jz8A05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	116
2.70.98.10.2.1.1.2	1px4A05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	8
2.70.98.10.2.1.1.3	1f49A05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.4	1f49B05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismOther glycan degradation	1
2.70.98.10.2.1.1.5	1f49C05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.6	1f49D05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismOther glycan degradation	1
2.70.98.10.2.1.1.7	1f49E05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.8	1f49F05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.9	1f49G05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.10	1f49H05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.11	1ghoI05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.12	1ghoJ05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingOther glycan degradation	1
2.70.98.10.2.1.1.13	1ghoK05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.14	1ghoL05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingOther glycan degradation	1
2.70.98.10.2.1.1.15	1ghoM05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.16	1ghoN05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.17	1ghoO05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.18	1ghoP05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.19	1jz0A05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.20	1jz0B05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.21	1jz0C05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.22	1jz0D05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.23	1jz0E05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.24	1jz0F05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingOther glycan degradation	1
2.70.98.10.2.1.1.25	1jz0G05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.26	1jz0H05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.27	1jz1I05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.28	1jz1J05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.29	1jz1K05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismOther glycan degradation	1
2.70.98.10.2.1.1.30	1jz1L05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.31	1jz1M05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.32	1jz1N05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.33	1jz1O05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingOther glycan degradation	1
2.70.98.10.2.1.1.34	1jz1P05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.35	1jyyA05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.36	1jyyB05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.37	1jyyC05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.38	1jyyD05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.39	1jyyE05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingOther glycan degradation	1
2.70.98.10.2.1.1.40	1jyyF05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.41	1jyyG05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismMetabolic pathways	1
2.70.98.10.2.1.1.42	1jyyH05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.43	1jyzI05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.44	1jyzJ05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismOther glycan degradation	1
2.70.98.10.2.1.1.45	1jyzK05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1
2.70.98.10.2.1.1.46	1jyzL05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.47	1jyzM05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.48	1jyzN05	Galactose metabolismLactose catabolic processProtein bindingSphingolipid metabolismEscherichia coli K-12	1
2.70.98.10.2.1.1.49	1jyzO05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingMetabolic pathways	1
2.70.98.10.2.1.1.50	1jyzP05	Galactose metabolismLactose catabolic processSphingolipid metabolismProtein bindingEscherichia coli K-12	1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.70.98.10.2.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S95 Family: 2.70.98.10.2.1.1

Classification Lineage (2.70.98.10.2.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Family Entries in S95 Family 2.70.98.10.2.1.1 (50)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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