S100 Family: 2.70.150.10.1.1.1.1

Representative domain: 1wpgB01

Classification Lineage (2.70.150.10.1.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.70	Distorted Sandwich
2.70.150	Calcium-transporting ATPase, cytoplasmic transduction domain A
2.70.150.10	Calcium-transporting ATPase, cytoplasmic transduction domain A	Gene3D
2.70.150.10.1
2.70.150.10.1.1
2.70.150.10.1.1.1
2.70.150.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.70.150.10.1.1.1.1 (20)

CATH code	Domain ID	Keywords
2.70.150.10.1.1.1.1.1	1wpgB01	perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., sarcoplasmic reticulum, calcium ion binding, ATP catabolic process, ER-Golgi intermediate compartment, calcium ion transport, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Oryctolagus cuniculus, integral to membrane, protein binding
2.70.150.10.1.1.1.1.2	1wpgC01	protein binding, Oryctolagus cuniculus, integral to membrane, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., ATP binding, perinuclear region of cytoplasm
2.70.150.10.1.1.1.1.3	2agvA01	protein binding, Oryctolagus cuniculus, integral to membrane, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., ATP binding, perinuclear region of cytoplasm
2.70.150.10.1.1.1.1.4	2agvB01	Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum, perinuclear region of cytoplasm, ATP binding, protein binding, Oryctolagus cuniculus, integral to membrane, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
2.70.150.10.1.1.1.1.5	2zbfA01	ER-Golgi intermediate compartment, ATP catabolic process, calcium ion transport, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, protein binding, Oryctolagus cuniculus, integral to membrane, perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., sarcoplasmic reticulum, calcium ion binding
2.70.150.10.1.1.1.1.6	3fgoA01	calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., ATP binding, perinuclear region of cytoplasm, Oryctolagus cuniculus, integral to membrane, protein binding, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ATP catabolic process, ER-Golgi intermediate compartment
2.70.150.10.1.1.1.1.7	3fgoB01	Oryctolagus cuniculus, integral to membrane, protein binding, calcium ion transport, ATP catabolic process, ER-Golgi intermediate compartment, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum, perinuclear region of cytoplasm, ATP binding
2.70.150.10.1.1.1.1.8	2zbgA01	calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., ATP binding, perinuclear region of cytoplasm, protein binding, Oryctolagus cuniculus, integral to membrane, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process
2.70.150.10.1.1.1.1.9	2o9jA01	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, ER-Golgi intermediate compartment, ATP catabolic process, calcium ion transport, protein binding, Oryctolagus cuniculus, integral to membrane, ATP binding, perinuclear region of cytoplasm, sarcoplasmic reticulum, calcium ion binding, Calcium-transporting ATPase.
2.70.150.10.1.1.1.1.10	2c8kA01	calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, protein binding, Oryctolagus cuniculus, integral to membrane, perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum
2.70.150.10.1.1.1.1.11	1xp5A01	ATP binding, perinuclear region of cytoplasm, calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, protein binding, Oryctolagus cuniculus, integral to membrane
2.70.150.10.1.1.1.1.12	3b9rA01	Oryctolagus cuniculus, integral to membrane, protein binding, calcium ion transport, ATP catabolic process, ER-Golgi intermediate compartment, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum, perinuclear region of cytoplasm, ATP binding
2.70.150.10.1.1.1.1.13	3b9rB01	ATP binding, perinuclear region of cytoplasm, sarcoplasmic reticulum, calcium ion binding, Calcium-transporting ATPase., Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, ATP catabolic process, ER-Golgi intermediate compartment, calcium ion transport, Oryctolagus cuniculus, integral to membrane, protein binding
2.70.150.10.1.1.1.1.14	1iwoA01	calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, protein binding, Oryctolagus cuniculus, integral to membrane, perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum
2.70.150.10.1.1.1.1.15	1iwoB01	calcium ion binding, sarcoplasmic reticulum, Calcium-transporting ATPase., ATP binding, perinuclear region of cytoplasm, Oryctolagus cuniculus, integral to membrane, protein binding, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium ion transport, ATP catabolic process, ER-Golgi intermediate compartment
2.70.150.10.1.1.1.1.16	2c88A01	ER-Golgi intermediate compartment, ATP catabolic process, calcium ion transport, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, protein binding, Oryctolagus cuniculus, integral to membrane, perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., sarcoplasmic reticulum, calcium ion binding
2.70.150.10.1.1.1.1.17	2c8lA01	Calcium-transporting ATPase., sarcoplasmic reticulum, calcium ion binding, perinuclear region of cytoplasm, ATP binding, protein binding, Oryctolagus cuniculus, integral to membrane, ER-Golgi intermediate compartment, ATP catabolic process, calcium ion transport, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity
2.70.150.10.1.1.1.1.18	3fpsA01	ATP binding, perinuclear region of cytoplasm, sarcoplasmic reticulum, calcium ion binding, Calcium-transporting ATPase., Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, calcium-transporting ATPase activity, sarcoplasmic reticulum membrane, ER-Golgi intermediate compartment, ATP catabolic process, calcium ion transport, protein binding, Oryctolagus cuniculus, integral to membrane
2.70.150.10.1.1.1.1.19	2by4A01	perinuclear region of cytoplasm, ATP binding, Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum, calcium ion transport, ER-Golgi intermediate compartment, ATP catabolic process, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, protein binding, Oryctolagus cuniculus, integral to membrane
2.70.150.10.1.1.1.1.20	2oa0A01	Calcium-transporting ATPase., calcium ion binding, sarcoplasmic reticulum, perinuclear region of cytoplasm, ATP binding, Oryctolagus cuniculus, integral to membrane, protein binding, calcium ion transport, ATP catabolic process, ER-Golgi intermediate compartment, sarcoplasmic reticulum membrane, calcium-transporting ATPase activity, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.70.150.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.70.150.10.1.1.1.1

Classification Lineage (2.70.150.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.70.150.10.1.1.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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