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CATH Superfamily 2.60.40.2150

Interleukin-17 receptor A/B, fibronectin-III-like domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Interleukin-17 receptor A/B, fibronectin-III-like domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Interleukin-17 receptor A/B, fibronectin-III-like domain 2

The five IL-17 receptors (IL-17RA IL-17RE) are not homologous to any known receptors, and exhibit considerable sequence divergence between one another. They all contain extracellular domains composed of fibronectin type-III (FnIII) domains, and cytoplasmic SEF/IL-17R (SEFIR) domains that show loose homology to Toll/IL-1R (TLR) domains. The IL-17RA ectodomain is composed of two unusual FnIII domain modules joined by an 18-amino acid linker, members of this superfamily share the structure of the second FnIII domain (D2). The two linked fibronectin-type domains bind two molecules of IL-17 at one of its receptor-binding interfaces. This allows the other interface to bind to another receptor, thus allowing the IL-17 family of homodimeric cytokines to coordinate two different receptors PMID:23695682,PMID:19838198.

GO Diversity

Unique GO annotations
22 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
163 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 5
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC:
Unique GO: 22
Taxonomy
Unique Species: 163