S100 Family: 2.60.40.1180.10.1.1.1

Representative domain: 3hg3B02

Classification Lineage (2.60.40.1180.10.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.1180	Golgi alpha-mannosidase II	Gene3D
2.60.40.1180.10
2.60.40.1180.10.1
2.60.40.1180.10.1.1
2.60.40.1180.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	18

Non-Redundant Representatives (18)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.60.40.1180.10.1.1.1 (18)

CATH code	Domain ID	Keywords
2.60.40.1180.10.1.1.1.1	3hg3B02	protein homodimerization activity, Golgi apparatus, Glycosphingolipid biosynthesis - globo series, Lysosome, extracellular region, Homo sapiens, receptor binding, oligosaccharide metabolic process, Sphingolipid metabolism, Galactose metabolism, alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, Alpha-galactosidase., lysosome
2.60.40.1180.10.1.1.1.2	3hg3A02	Glycosphingolipid biosynthesis - globo series, Lysosome, extracellular region, Golgi apparatus, protein homodimerization activity, oligosaccharide metabolic process, Sphingolipid metabolism, Galactose metabolism, Homo sapiens, receptor binding, alpha-galactosidase [EC:3.2.1.22], Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, lysosome, Alpha-galactosidase., Alpha-galactosidase A
2.60.40.1180.10.1.1.1.3	3gxpA02	alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, Alpha-galactosidase., lysosome, Alpha-galactosidase A, Golgi apparatus, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, protein homodimerization activity, Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding
2.60.40.1180.10.1.1.1.4	3gxpB02	alpha-galactosidase [EC:3.2.1.22], Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, lysosome, Alpha-galactosidase., Alpha-galactosidase A, Lysosome, Glycosphingolipid biosynthesis - globo series, extracellular region, Golgi apparatus, protein homodimerization activity, oligosaccharide metabolic process, Galactose metabolism, Sphingolipid metabolism, Homo sapiens, receptor binding
2.60.40.1180.10.1.1.1.5	3hg2A02	Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding, Golgi apparatus, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, protein homodimerization activity, Alpha-galactosidase., lysosome, Alpha-galactosidase A, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process
2.60.40.1180.10.1.1.1.6	3hg4A02	Glycosphingolipid biosynthesis - globo series, Lysosome, extracellular region, Golgi apparatus, protein homodimerization activity, oligosaccharide metabolic process, Sphingolipid metabolism, Galactose metabolism, Homo sapiens, receptor binding, alpha-galactosidase [EC:3.2.1.22], Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, lysosome, Alpha-galactosidase., Alpha-galactosidase A
2.60.40.1180.10.1.1.1.7	3hg5A02	Golgi apparatus, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, protein homodimerization activity, Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, Alpha-galactosidase., lysosome, Alpha-galactosidase A
2.60.40.1180.10.1.1.1.8	3hg2B02	alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, Alpha-galactosidase., lysosome, protein homodimerization activity, Golgi apparatus, extracellular region, Lysosome, Glycosphingolipid biosynthesis - globo series, Homo sapiens, receptor binding, Galactose metabolism, Sphingolipid metabolism, oligosaccharide metabolic process
2.60.40.1180.10.1.1.1.9	3hg5B02	protein homodimerization activity, Glycosphingolipid biosynthesis - globo series, Lysosome, extracellular region, Golgi apparatus, Homo sapiens, receptor binding, oligosaccharide metabolic process, Sphingolipid metabolism, Galactose metabolism, Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, lysosome, Alpha-galactosidase.
2.60.40.1180.10.1.1.1.10	3hg4B02	Golgi apparatus, extracellular region, Lysosome, Glycosphingolipid biosynthesis - globo series, protein homodimerization activity, Galactose metabolism, Sphingolipid metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, Alpha-galactosidase., lysosome, Alpha-galactosidase A
2.60.40.1180.10.1.1.1.11	3gxtA02	Alpha-galactosidase., lysosome, Alpha-galactosidase A, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, Galactose metabolism, Sphingolipid metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding, Golgi apparatus, extracellular region, Lysosome, Glycosphingolipid biosynthesis - globo series, protein homodimerization activity
2.60.40.1180.10.1.1.1.12	3gxtB02	Galactose metabolism, Sphingolipid metabolism, oligosaccharide metabolic process, Homo sapiens, receptor binding, Golgi apparatus, extracellular region, Lysosome, Glycosphingolipid biosynthesis - globo series, protein homodimerization activity, Alpha-galactosidase., lysosome, Alpha-galactosidase A, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process
2.60.40.1180.10.1.1.1.13	3gxnA02	Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, lysosome, Alpha-galactosidase., protein homodimerization activity, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, Golgi apparatus, Homo sapiens, receptor binding, Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process
2.60.40.1180.10.1.1.1.14	3gxnB02	protein homodimerization activity, Golgi apparatus, Lysosome, Glycosphingolipid biosynthesis - globo series, extracellular region, Homo sapiens, receptor binding, oligosaccharide metabolic process, Galactose metabolism, Sphingolipid metabolism, alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, Alpha-galactosidase., lysosome
2.60.40.1180.10.1.1.1.15	1r46A02	lysosome, Alpha-galactosidase., Alpha-galactosidase A, alpha-galactosidase [EC:3.2.1.22], Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, oligosaccharide metabolic process, Sphingolipid metabolism, Galactose metabolism, Homo sapiens, receptor binding, Glycosphingolipid biosynthesis - globo series, Lysosome, extracellular region, Golgi apparatus, protein homodimerization activity
2.60.40.1180.10.1.1.1.16	1r46B02	Alpha-galactosidase., lysosome, Alpha-galactosidase A, alpha-galactosidase [EC:3.2.1.22], alpha-galactosidase activity, Glycerolipid metabolism, glycosphingolipid catabolic process, oligosaccharide metabolic process, Galactose metabolism, Sphingolipid metabolism, Homo sapiens, receptor binding, Golgi apparatus, Lysosome, Glycosphingolipid biosynthesis - globo series, extracellular region, protein homodimerization activity
2.60.40.1180.10.1.1.1.17	1r47A02	Alpha-galactosidase A, lysosome, Alpha-galactosidase., Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, alpha-galactosidase [EC:3.2.1.22], Homo sapiens, receptor binding, Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process, protein homodimerization activity, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, Golgi apparatus
2.60.40.1180.10.1.1.1.18	1r47B02	Glycerolipid metabolism, glycosphingolipid catabolic process, alpha-galactosidase activity, alpha-galactosidase [EC:3.2.1.22], Alpha-galactosidase A, lysosome, Alpha-galactosidase., protein homodimerization activity, extracellular region, Glycosphingolipid biosynthesis - globo series, Lysosome, Golgi apparatus, Homo sapiens, receptor binding, Sphingolipid metabolism, Galactose metabolism, oligosaccharide metabolic process

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.40.1180.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.60.40.1180.10.1.1.1

Classification Lineage (2.60.40.1180.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.60.40.1180.10.1.1.1 (18)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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