S100 Family: 2.60.40.10.46.1.1.1

Molscript image for 1my5A00
Representative domain: 1my5A00
PDB coordinates for domain 1my5A00

Classification Lineage (2.60.40.10.46.1.1.1)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.10 Immunoglobulins Gene3D
2.60.40.10.46
2.60.40.10.46.1
2.60.40.10.46.1.1
2.60.40.10.46.1.1.1

Summary of Non-Redundant Representatives
- - - - - - - - 16

S100 Count Entries in S100 Family 2.60.40.10.46.1.1.1 (16)

CATH Level CATH code Domain ID Keywords Thumbnail
2.60.40.10.46.1.1.1.1 1my5A00 RIG-I-like receptor signaling pathway, liver development, Apoptosis, Toll-like receptor signaling pathway, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, Leishmaniasis, NOD-like receptor signaling pathway, Transcription factor p65, hair follicle development, Chemokine signaling pathway, Pancreatic cancer, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Neurotrophin signaling pathway, transcription activator activity, Mus musculus, transcription factor p65, Small cell lung cancer, Prostate cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Pathways in cancer, Acute myeloid leukemia, organ morphogenesis Molscript image for 1my5A00
2.60.40.10.46.1.1.1.2 1my5B00 Leishmaniasis, NOD-like receptor signaling pathway, Chronic myeloid leukemia, positive regulation of interleukin-12 biosynthetic process, hair follicle development, Transcription factor p65, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, RIG-I-like receptor signaling pathway, Apoptosis, Toll-like receptor signaling pathway, liver development, Pathways in cancer, organ morphogenesis, Acute myeloid leukemia, Prostate cancer, Small cell lung cancer, MAPK signaling pathway, negative regulation of protein catabolic process, Neurotrophin signaling pathway, transcription factor p65, Mus musculus, transcription activator activity, Chemokine signaling pathway, Pancreatic cancer, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway Molscript image for 1my5B00
2.60.40.10.46.1.1.1.3 1bftA00 hair follicle development, Transcription factor p65, positive regulation of interleukin-12 biosynthetic process, Leishmaniasis, NOD-like receptor signaling pathway, Chronic myeloid leukemia, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, liver development, Toll-like receptor signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, transcription activator activity, transcription factor p65, Mus musculus, Neurotrophin signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Pancreatic cancer, Chemokine signaling pathway Molscript image for 1bftA00
2.60.40.10.46.1.1.1.4 1bftB00 Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Apoptosis, liver development, NOD-like receptor signaling pathway, Leishmaniasis, Chronic myeloid leukemia, positive regulation of interleukin-12 biosynthetic process, Transcription factor p65, hair follicle development, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, Neurotrophin signaling pathway, Mus musculus, transcription factor p65, transcription activator activity, Chemokine signaling pathway, Pancreatic cancer, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway, Pathways in cancer, organ morphogenesis, Acute myeloid leukemia, Prostate cancer, Small cell lung cancer, MAPK signaling pathway, negative regulation of protein catabolic process Molscript image for 1bftB00
2.60.40.10.46.1.1.1.5 1oy3B00 Pathways in cancer, Acute myeloid leukemia, organ morphogenesis, Small cell lung cancer, Prostate cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Neurotrophin signaling pathway, transcription activator activity, Mus musculus, transcription factor p65, Chemokine signaling pathway, Pancreatic cancer, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, Leishmaniasis, NOD-like receptor signaling pathway, Transcription factor p65, hair follicle development, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, RIG-I-like receptor signaling pathway, liver development, Apoptosis, Toll-like receptor signaling pathway Molscript image for 1oy3B00
2.60.40.10.46.1.1.1.6 2ramA02 positive regulation of interleukin-12 biosynthetic process, Leishmaniasis, Chronic myeloid leukemia, NOD-like receptor signaling pathway, Transcription factor p65, hair follicle development, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, RIG-I-like receptor signaling pathway, liver development, Toll-like receptor signaling pathway, Apoptosis, Pathways in cancer, Acute myeloid leukemia, organ morphogenesis, Small cell lung cancer, Prostate cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Neurotrophin signaling pathway, transcription activator activity, Mus musculus, transcription factor p65, Chemokine signaling pathway, Pancreatic cancer, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway Molscript image for 2ramA02
2.60.40.10.46.1.1.1.7 2ramB02 Transcription factor p65, hair follicle development, positive regulation of interleukin-12 biosynthetic process, NOD-like receptor signaling pathway, Chronic myeloid leukemia, Leishmaniasis, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, liver development, Toll-like receptor signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, transcription activator activity, Mus musculus, transcription factor p65, Neurotrophin signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Pancreatic cancer, Chemokine signaling pathway Molscript image for 2ramB02
2.60.40.10.46.1.1.1.8 1leiA02 transcription activator activity, transcription factor p65, Mus musculus, Neurotrophin signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Pancreatic cancer, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, liver development, Toll-like receptor signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway, hair follicle development, Transcription factor p65, positive regulation of interleukin-12 biosynthetic process, NOD-like receptor signaling pathway, Leishmaniasis, Chronic myeloid leukemia, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide Molscript image for 1leiA02
2.60.40.10.46.1.1.1.9 1ramA02 transcription activator activity, transcription factor p65, Mus musculus, Neurotrophin signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Pancreatic cancer, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, liver development, Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, hair follicle development, Transcription factor p65, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, NOD-like receptor signaling pathway, Leishmaniasis, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide Molscript image for 1ramA02
2.60.40.10.46.1.1.1.10 1ramB02 B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, Leishmaniasis, NOD-like receptor signaling pathway, hair follicle development, Transcription factor p65, RIG-I-like receptor signaling pathway, liver development, Toll-like receptor signaling pathway, Apoptosis, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, Small cell lung cancer, Prostate cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Pathways in cancer, Acute myeloid leukemia, organ morphogenesis, Pancreatic cancer, Chemokine signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Neurotrophin signaling pathway, transcription activator activity, transcription factor p65, Mus musculus Molscript image for 1ramB02
2.60.40.10.46.1.1.1.11 1le5A02 B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, Leishmaniasis, Chronic myeloid leukemia, NOD-like receptor signaling pathway, positive regulation of interleukin-12 biosynthetic process, Transcription factor p65, hair follicle development, RIG-I-like receptor signaling pathway, Apoptosis, Toll-like receptor signaling pathway, liver development, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Prostate cancer, Small cell lung cancer, MAPK signaling pathway, negative regulation of protein catabolic process, Pathways in cancer, organ morphogenesis, Acute myeloid leukemia, Chemokine signaling pathway, Pancreatic cancer, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway, Neurotrophin signaling pathway, Mus musculus, transcription factor p65, transcription activator activity Molscript image for 1le5A02
2.60.40.10.46.1.1.1.12 1le5E02 Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Apoptosis, liver development, Chronic myeloid leukemia, Leishmaniasis, NOD-like receptor signaling pathway, positive regulation of interleukin-12 biosynthetic process, Transcription factor p65, hair follicle development, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, Neurotrophin signaling pathway, Mus musculus, transcription factor p65, transcription activator activity, Chemokine signaling pathway, Pancreatic cancer, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway, Pathways in cancer, organ morphogenesis, Acute myeloid leukemia, Prostate cancer, Small cell lung cancer, MAPK signaling pathway, negative regulation of protein catabolic process Molscript image for 1le5E02
2.60.40.10.46.1.1.1.13 2i9tA02 transcription activator activity, transcription factor p65, Mus musculus, Neurotrophin signaling pathway, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Pancreatic cancer, Chemokine signaling pathway, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway, liver development, Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, hair follicle development, Transcription factor p65, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, Leishmaniasis, NOD-like receptor signaling pathway, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide Molscript image for 2i9tA02
2.60.40.10.46.1.1.1.14 1vkxA02 negative regulation of protein catabolic process, MAPK signaling pathway, Small cell lung cancer, Prostate cancer, Acute myeloid leukemia, organ morphogenesis, Pathways in cancer, T cell receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Pancreatic cancer, transcription activator activity, transcription factor p65, Mus musculus, Neurotrophin signaling pathway, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, hair follicle development, Transcription factor p65, positive regulation of interleukin-12 biosynthetic process, Chronic myeloid leukemia, NOD-like receptor signaling pathway, Leishmaniasis, liver development, Toll-like receptor signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Adipocytokine signaling pathway Molscript image for 1vkxA02
2.60.40.10.46.1.1.1.15 1le9A02 Leishmaniasis, Chronic myeloid leukemia, NOD-like receptor signaling pathway, positive regulation of interleukin-12 biosynthetic process, Transcription factor p65, hair follicle development, B cell receptor signaling pathway, Chagas disease, response to muramyl dipeptide, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Apoptosis, liver development, Pathways in cancer, organ morphogenesis, Acute myeloid leukemia, Prostate cancer, Small cell lung cancer, MAPK signaling pathway, negative regulation of protein catabolic process, Neurotrophin signaling pathway, Mus musculus, transcription factor p65, transcription activator activity, Pancreatic cancer, Chemokine signaling pathway, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway Molscript image for 1le9A02
2.60.40.10.46.1.1.1.16 1le9E02 Toll-like receptor signaling pathway, Apoptosis, liver development, RIG-I-like receptor signaling pathway, Adipocytokine signaling pathway, sequence-specific enhancer binding RNA polymerase II transcription factor activity, Chagas disease, B cell receptor signaling pathway, response to muramyl dipeptide, Transcription factor p65, hair follicle development, NOD-like receptor signaling pathway, Chronic myeloid leukemia, Leishmaniasis, positive regulation of interleukin-12 biosynthetic process, Cytosolic DNA-sensing pathway, T cell receptor signaling pathway, Chemokine signaling pathway, Pancreatic cancer, Mus musculus, transcription factor p65, transcription activator activity, Neurotrophin signaling pathway, MAPK signaling pathway, negative regulation of protein catabolic process, Prostate cancer, Small cell lung cancer, organ morphogenesis, Acute myeloid leukemia, Pathways in cancer Molscript image for 1le9E02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.40.10.46.1.1.1