S100 Family: 2.60.40.10.12.1.1.1

Representative domain: 1ncwH02

Classification Lineage (2.60.40.10.12.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.10	Immunoglobulins	Gene3D
2.60.40.10.12
2.60.40.10.12.1
2.60.40.10.12.1.1
2.60.40.10.12.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	111

Non-Redundant Representatives (111)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.60.40.10.12.1.1.1 (111)

CATH code	Domain ID	Keywords
2.60.40.10.12.1.1.1.1	1ncwH02
2.60.40.10.12.1.1.1.2	1rukH02
2.60.40.10.12.1.1.1.3	1rupH02
2.60.40.10.12.1.1.1.4	1rumH02
2.60.40.10.12.1.1.1.5	1ruaH02
2.60.40.10.12.1.1.1.6	3g5yB02
2.60.40.10.12.1.1.1.7	1jguH02	Ighg protein, Mus musculus
2.60.40.10.12.1.1.1.8	1jgvH02	Ighg protein, Mus musculus
2.60.40.10.12.1.1.1.9	1yejH02
2.60.40.10.12.1.1.1.10	2brrH02
2.60.40.10.12.1.1.1.11	2brrY02
2.60.40.10.12.1.1.1.12	1dqqB02
2.60.40.10.12.1.1.1.13	1dqqD02
2.60.40.10.12.1.1.1.14	1nbyB02	antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, positive regulation of type I hypersensitivity, phagocytosis, engulfment, antigen processing and presentation, antigen binding, Mus musculus, complement activation, classical pathway, regulation of proteolysis, phagocytosis, recognition, multivesicular body, positive regulation of B cell activation, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis
2.60.40.10.12.1.1.1.15	1rulH02
2.60.40.10.12.1.1.1.16	1flrH02	positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis, complement activation, classical pathway, regulation of proteolysis, multivesicular body, phagocytosis, recognition, antigen processing and presentation, Mus musculus, antigen binding, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, phagocytosis, engulfment, positive regulation of type I hypersensitivity
2.60.40.10.12.1.1.1.17	1e4xH02
2.60.40.10.12.1.1.1.18	1e4xI02
2.60.40.10.12.1.1.1.19	1kn2H02
2.60.40.10.12.1.1.1.20	1kn4H02
2.60.40.10.12.1.1.1.21	1yecH02	Ig gamma-2A chain C region, A allele, Mus musculus
2.60.40.10.12.1.1.1.22	1yeiH02
2.60.40.10.12.1.1.1.23	3fo9B02
2.60.40.10.12.1.1.1.24	3fo9H02
2.60.40.10.12.1.1.1.25	1nbzB02	Igh protein, Mus musculus
2.60.40.10.12.1.1.1.26	1e4wH02
2.60.40.10.12.1.1.1.27	1cr9H02
2.60.40.10.12.1.1.1.28	1uywH02
2.60.40.10.12.1.1.1.29	1uywM02
2.60.40.10.12.1.1.1.30	1yefH02	Mus musculus, Ig gamma-2A chain C region, A allele
2.60.40.10.12.1.1.1.31	1yegH02	Mus musculus, Ig gamma-2A chain C region, A allele
2.60.40.10.12.1.1.1.32	2qhrH02
2.60.40.10.12.1.1.1.33	1dqjB02
2.60.40.10.12.1.1.1.34	1yekH02
2.60.40.10.12.1.1.1.35	2vl5A02
2.60.40.10.12.1.1.1.36	2vl5C02
2.60.40.10.12.1.1.1.37	1axtH02	positive regulation of phagocytosis, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation, multivesicular body, phagocytosis, recognition, complement activation, classical pathway, regulation of proteolysis, Mus musculus, antigen binding, antigen processing and presentation, phagocytosis, engulfment, positive regulation of type I hypersensitivity, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity
2.60.40.10.12.1.1.1.38	1dqmH02
2.60.40.10.12.1.1.1.39	1ndmB02	multivesicular body, phagocytosis, recognition, complement activation, classical pathway, regulation of proteolysis, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation, phagocytosis, engulfment, positive regulation of type I hypersensitivity, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, Mus musculus, antigen binding, antigen processing and presentation
2.60.40.10.12.1.1.1.40	1xgpB02
2.60.40.10.12.1.1.1.41	1xgqB02
2.60.40.10.12.1.1.1.42	1xgrB02
2.60.40.10.12.1.1.1.43	1xgtB02
2.60.40.10.12.1.1.1.44	1xguB02
2.60.40.10.12.1.1.1.45	1hilB02
2.60.40.10.12.1.1.1.46	1yeeH02	Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis, positive regulation of B cell activation, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, phagocytosis, recognition, multivesicular body, complement activation, classical pathway, regulation of proteolysis, antigen binding, Mus musculus, antigen processing and presentation, positive regulation of type I hypersensitivity, phagocytosis, engulfment, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating
2.60.40.10.12.1.1.1.47	1hilD02
2.60.40.10.12.1.1.1.48	2z4qB02
2.60.40.10.12.1.1.1.49	1a3rH02	Mus musculus, Igh protein
2.60.40.10.12.1.1.1.50	3cmoH02	Mus musculus, Igh protein
2.60.40.10.12.1.1.1.51	3cmoY02	Mus musculus, Igh protein
2.60.40.10.12.1.1.1.52	2ddqH02
2.60.40.10.12.1.1.1.53	1nd0B02
2.60.40.10.12.1.1.1.54	1nd0D02
2.60.40.10.12.1.1.1.55	1nd0F02
2.60.40.10.12.1.1.1.56	1nd0H02
2.60.40.10.12.1.1.1.57	1ehlH02
2.60.40.10.12.1.1.1.58	1igjB02
2.60.40.10.12.1.1.1.59	1igjD02
2.60.40.10.12.1.1.1.60	1kb5H02	positive regulation of phagocytosis, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, positive regulation of B cell activation, multivesicular body, phagocytosis, recognition, regulation of proteolysis, complement activation, classical pathway, Mus musculus, antigen binding, antigen processing and presentation, phagocytosis, engulfment, positive regulation of type I hypersensitivity, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity
2.60.40.10.12.1.1.1.61	1mnuH02
2.60.40.10.12.1.1.1.62	1ncbH02	phagocytosis, engulfment, positive regulation of type I hypersensitivity, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity, Mus musculus, antigen binding, antigen processing and presentation, multivesicular body, phagocytosis, recognition, complement activation, classical pathway, regulation of proteolysis, positive regulation of phagocytosis, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation
2.60.40.10.12.1.1.1.63	1nccH02	antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, phagocytosis, engulfment, positive regulation of type I hypersensitivity, antigen processing and presentation, Mus musculus, antigen binding, regulation of proteolysis, complement activation, classical pathway, multivesicular body, phagocytosis, recognition, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, positive regulation of B cell activation, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis
2.60.40.10.12.1.1.1.64	1ru9H02
2.60.40.10.12.1.1.1.65	2vdrH02
2.60.40.10.12.1.1.1.66	1tqbB02
2.60.40.10.12.1.1.1.67	1yehH02	Ig gamma-2A chain C region, A allele, Mus musculus
2.60.40.10.12.1.1.1.68	1kegH02
2.60.40.10.12.1.1.1.69	1tpxB02
2.60.40.10.12.1.1.1.70	2bdnH02
2.60.40.10.12.1.1.1.71	1mpaH02	Mus musculus, Ighg protein
2.60.40.10.12.1.1.1.72	2mpaH02	Mus musculus, Ighg protein
2.60.40.10.12.1.1.1.73	2vdoH02
2.60.40.10.12.1.1.1.74	2r0wH02	Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region, Mus musculus
2.60.40.10.12.1.1.1.75	1igiH02
2.60.40.10.12.1.1.1.76	2vdqH02
2.60.40.10.12.1.1.1.77	4fabH02	Mus musculus, antigen binding, antigen processing and presentation, phagocytosis, engulfment, positive regulation of type I hypersensitivity, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation, multivesicular body, phagocytosis, recognition, complement activation, classical pathway, regulation of proteolysis
2.60.40.10.12.1.1.1.78	1ggcH02	antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, phagocytosis, engulfment, positive regulation of type I hypersensitivity, antigen processing and presentation, Mus musculus, antigen binding, regulation of proteolysis, complement activation, classical pathway, multivesicular body, phagocytosis, recognition, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, positive regulation of B cell activation, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis
2.60.40.10.12.1.1.1.79	1frgH02
2.60.40.10.12.1.1.1.80	1ggbH02	Mus musculus, antigen binding, antigen processing and presentation, phagocytosis, engulfment, positive regulation of type I hypersensitivity, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity, positive regulation of phagocytosis, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of type IIa hypersensitivity, endosome to lysosome transport, positive regulation of B cell activation, multivesicular body, phagocytosis, recognition, complement activation, classical pathway, regulation of proteolysis
2.60.40.10.12.1.1.1.81	1ggiJ02	Ig gamma-2A chain C region, A allele, Mus musculus
2.60.40.10.12.1.1.1.82	1ifhH02
2.60.40.10.12.1.1.1.83	1tqcB02
2.60.40.10.12.1.1.1.84	1blnB02
2.60.40.10.12.1.1.1.85	1blnD02
2.60.40.10.12.1.1.1.86	1ggiH02	Ig gamma-2A chain C region, A allele, Mus musculus
2.60.40.10.12.1.1.1.87	1plgH02	antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, phagocytosis, engulfment, positive regulation of type I hypersensitivity, antigen processing and presentation, Mus musculus, antigen binding, regulation of proteolysis, complement activation, classical pathway, multivesicular body, phagocytosis, recognition, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, positive regulation of B cell activation, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis
2.60.40.10.12.1.1.1.88	2vdlH02
2.60.40.10.12.1.1.1.89	1cu4H02
2.60.40.10.12.1.1.1.90	1ob1B02
2.60.40.10.12.1.1.1.91	1ob1E02
2.60.40.10.12.1.1.1.92	2vdkH02
2.60.40.10.12.1.1.1.93	2vdpH02
2.60.40.10.12.1.1.1.94	1fptH02	antigen binding, Mus musculus, antigen processing and presentation, positive regulation of type I hypersensitivity, phagocytosis, engulfment, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis, positive regulation of B cell activation, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, phagocytosis, recognition, multivesicular body, regulation of proteolysis, complement activation, classical pathway
2.60.40.10.12.1.1.1.95	1bbdH02
2.60.40.10.12.1.1.1.96	2vdmH02
2.60.40.10.12.1.1.1.97	2vdnH02
2.60.40.10.12.1.1.1.98	1yntB02
2.60.40.10.12.1.1.1.99	1yntD02
2.60.40.10.12.1.1.1.100	1himL02
2.60.40.10.12.1.1.1.101	1himM02
2.60.40.10.12.1.1.1.102	1hinH02
2.60.40.10.12.1.1.1.103	1ncdH02	antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating, positive regulation of type I hypersensitivity, phagocytosis, engulfment, antigen processing and presentation, antigen binding, Mus musculus, regulation of proteolysis, complement activation, classical pathway, phagocytosis, recognition, multivesicular body, positive regulation of B cell activation, endosome to lysosome transport, positive regulation of type IIa hypersensitivity, Ig gamma-2A chain C region, membrane-bound form, early endosome to late endosome transport, positive regulation of phagocytosis
2.60.40.10.12.1.1.1.104	3bgfB02
2.60.40.10.12.1.1.1.105	3bgfH02
2.60.40.10.12.1.1.1.106	2vc2H02
2.60.40.10.12.1.1.1.107	1txvH02
2.60.40.10.12.1.1.1.108	1ty3H02
2.60.40.10.12.1.1.1.109	1ty5H02
2.60.40.10.12.1.1.1.110	1ty6H02
2.60.40.10.12.1.1.1.111	1ty7H02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.40.10.12.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.60.40.10.12.1.1.1

Classification Lineage (2.60.40.10.12.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.60.40.10.12.1.1.1 (111)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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