S100 Family: 2.60.40.10.10.1.1.1

Representative domain: 3d9aH02

Classification Lineage (2.60.40.10.10.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.10	Immunoglobulins	Gene3D
2.60.40.10.10
2.60.40.10.10.1
2.60.40.10.10.1.1
2.60.40.10.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	169

Non-Redundant Representatives (169)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.60.40.10.10.1.1.1 (169)

CATH code	Domain ID	Keywords
2.60.40.10.10.1.1.1.1	3d9aH02
2.60.40.10.10.1.1.1.2	1q9rB02
2.60.40.10.10.1.1.1.3	1q9qB02
2.60.40.10.10.1.1.1.4	1rurH02
2.60.40.10.10.1.1.1.5	2w60A02
2.60.40.10.10.1.1.1.6	1nlbH02
2.60.40.10.10.1.1.1.7	2vxtH02
2.60.40.10.10.1.1.1.8	1q9oD02
2.60.40.10.10.1.1.1.9	2r23B02
2.60.40.10.10.1.1.1.10	1q9vB02
2.60.40.10.10.1.1.1.11	1q9tB02
2.60.40.10.10.1.1.1.12	1q9wB02
2.60.40.10.10.1.1.1.13	2dquH02
2.60.40.10.10.1.1.1.14	2a77H02
2.60.40.10.10.1.1.1.15	1q9wD02
2.60.40.10.10.1.1.1.16	1q9oB02
2.60.40.10.10.1.1.1.17	2r1xB02
2.60.40.10.10.1.1.1.18	2r1yB02
2.60.40.10.10.1.1.1.19	2r1wB02
2.60.40.10.10.1.1.1.20	1e6oH02
2.60.40.10.10.1.1.1.21	2r2bB02
2.60.40.10.10.1.1.1.22	1p7kH02
2.60.40.10.10.1.1.1.23	3ggwD02
2.60.40.10.10.1.1.1.24	1ruqH02
2.60.40.10.10.1.1.1.25	1f3dH02
2.60.40.10.10.1.1.1.26	1f3dK02
2.60.40.10.10.1.1.1.27	12e8H02
2.60.40.10.10.1.1.1.28	12e8P02
2.60.40.10.10.1.1.1.29	1orsB02	positive regulation of phagocytosis, positive regulation of type IIa hypersensitivity, phagocytosis, recognition, antibacterial humoral response, complement activation, classical pathway, antigen binding, Mus musculus, Ig gamma-1 chain C region, membrane-bound form, positive regulation of type I hypersensitivity, phagocytosis, engulfment, antibody-dependent cellular cytotoxicity, immunoglobulin complex, circulating
2.60.40.10.10.1.1.1.30	1p7kB02
2.60.40.10.10.1.1.1.31	3ggwB02
2.60.40.10.10.1.1.1.32	1a3lH02
2.60.40.10.10.1.1.1.33	1gpoH02
2.60.40.10.10.1.1.1.34	1gpoI02
2.60.40.10.10.1.1.1.35	1t2qH02	Mus musculus, antigen binding, antibody-dependent cellular cytotoxicity, Ig gamma-1 chain C region secreted form, immunoglobulin complex, circulating, phagocytosis, engulfment, positive regulation of type I hypersensitivity, positive regulation of type IIa hypersensitivity, positive regulation of phagocytosis, complement activation, classical pathway, antibacterial humoral response, phagocytosis, recognition
2.60.40.10.10.1.1.1.36	2dqtH02
2.60.40.10.10.1.1.1.37	3bz4B02
2.60.40.10.10.1.1.1.38	3bz4D02
2.60.40.10.10.1.1.1.39	3bz4F02
2.60.40.10.10.1.1.1.40	3bz4H02
2.60.40.10.10.1.1.1.41	3c6sB02
2.60.40.10.10.1.1.1.42	3c6sD02
2.60.40.10.10.1.1.1.43	3c6sF02
2.60.40.10.10.1.1.1.44	3c6sH02
2.60.40.10.10.1.1.1.45	1q9kB02
2.60.40.10.10.1.1.1.46	3cviH02
2.60.40.10.10.1.1.1.47	25c8H02	Mus musculus, antigen binding, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity, phagocytosis, engulfment, Ig gamma-1 chain C region, membrane-bound form, positive regulation of type I hypersensitivity, positive regulation of type IIa hypersensitivity, positive regulation of phagocytosis, complement activation, classical pathway, antibacterial humoral response, phagocytosis, recognition
2.60.40.10.10.1.1.1.48	35c8H02
2.60.40.10.10.1.1.1.49	3bpcB02
2.60.40.10.10.1.1.1.50	2zpkI02
2.60.40.10.10.1.1.1.51	3hzvB02
2.60.40.10.10.1.1.1.52	1l7tH02
2.60.40.10.10.1.1.1.53	1nc2B02
2.60.40.10.10.1.1.1.54	2zpkH02
2.60.40.10.10.1.1.1.55	2ai0H02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.56	2fr4B02
2.60.40.10.10.1.1.1.57	2fr4H02
2.60.40.10.10.1.1.1.58	1vpoH02
2.60.40.10.10.1.1.1.59	3eotH02
2.60.40.10.10.1.1.1.60	1fnsH02
2.60.40.10.10.1.1.1.61	2d03H02
2.60.40.10.10.1.1.1.62	2ai0I02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.63	2ai0J02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.64	2ai0K02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.65	3c5sB02
2.60.40.10.10.1.1.1.66	3c5sD02
2.60.40.10.10.1.1.1.67	1mhhB02
2.60.40.10.10.1.1.1.68	1ct8B02
2.60.40.10.10.1.1.1.69	1ct8D02
2.60.40.10.10.1.1.1.70	1il1A02
2.60.40.10.10.1.1.1.71	2r2hB02
2.60.40.10.10.1.1.1.72	1mhhD02
2.60.40.10.10.1.1.1.73	1nc4B02
2.60.40.10.10.1.1.1.74	3hzkB02
2.60.40.10.10.1.1.1.75	1q9lB02
2.60.40.10.10.1.1.1.76	1q9lD02
2.60.40.10.10.1.1.1.77	1nc2D02
2.60.40.10.10.1.1.1.78	1f4wH02
2.60.40.10.10.1.1.1.79	1f4xH02
2.60.40.10.10.1.1.1.80	2dtmH02	Ig heavy chain V region 914, Mus musculus
2.60.40.10.10.1.1.1.81	1i8mB02	Mus musculus, antigen binding, activation of MAPK activity, antigen processing and presentation, transmembrane receptor activity, positive regulation of MAPKKK cascade, VH186.2-D-J-C mu protein, protein binding, positive regulation of endocytosis, positive regulation of peptidyl-tyrosine phosphorylation, immunoglobulin complex, circulating, early endosome to late endosome transport, external side of plasma membrane, perinuclear region of cytoplasm, humoral immune response mediated by circulating immunoglobulin, B cell receptor complex, B cell receptor signaling pathway, positive regulation of B cell proliferation
2.60.40.10.10.1.1.1.82	1i8mH02	humoral immune response mediated by circulating immunoglobulin, B cell receptor signaling pathway, B cell receptor complex, positive regulation of B cell proliferation, early endosome to late endosome transport, perinuclear region of cytoplasm, external side of plasma membrane, VH186.2-D-J-C mu protein, positive regulation of endocytosis, protein binding, positive regulation of peptidyl-tyrosine phosphorylation, immunoglobulin complex, circulating, antigen binding, Mus musculus, activation of MAPK activity, transmembrane receptor activity, antigen processing and presentation, positive regulation of MAPKKK cascade
2.60.40.10.10.1.1.1.83	3hzyB02
2.60.40.10.10.1.1.1.84	1n64H02
2.60.40.10.10.1.1.1.85	1oakH02
2.60.40.10.10.1.1.1.86	2vxuH02
2.60.40.10.10.1.1.1.87	2vxuI02
2.60.40.10.10.1.1.1.88	1jglH02
2.60.40.10.10.1.1.1.89	2h1pH02
2.60.40.10.10.1.1.1.90	2r2eB02
2.60.40.10.10.1.1.1.91	1nc4D02
2.60.40.10.10.1.1.1.92	1xf3B02
2.60.40.10.10.1.1.1.93	1xf3H02
2.60.40.10.10.1.1.1.94	2b2xH02
2.60.40.10.10.1.1.1.95	2b2xI02
2.60.40.10.10.1.1.1.96	2orbH02
2.60.40.10.10.1.1.1.97	2orbI02
2.60.40.10.10.1.1.1.98	2aabH02
2.60.40.10.10.1.1.1.99	1xf2B02
2.60.40.10.10.1.1.1.100	1xf2H02
2.60.40.10.10.1.1.1.101	3dggD02
2.60.40.10.10.1.1.1.102	15c8H02	positive regulation of type IIa hypersensitivity, positive regulation of phagocytosis, complement activation, classical pathway, phagocytosis, recognition, antibacterial humoral response, antigen binding, Mus musculus, immunoglobulin complex, circulating, antibody-dependent cellular cytotoxicity, Ig gamma-1 chain C region, membrane-bound form, positive regulation of type I hypersensitivity, phagocytosis, engulfment
2.60.40.10.10.1.1.1.103	1fgnH02
2.60.40.10.10.1.1.1.104	2zkhH02
2.60.40.10.10.1.1.1.105	3dggB02
2.60.40.10.10.1.1.1.106	1i9jH02
2.60.40.10.10.1.1.1.107	1xf5B02
2.60.40.10.10.1.1.1.108	1xf5D02
2.60.40.10.10.1.1.1.109	1ymhB02
2.60.40.10.10.1.1.1.110	1ymhD02
2.60.40.10.10.1.1.1.111	1a0qH02
2.60.40.10.10.1.1.1.112	2a1wH02	Igh protein, Mus musculus
2.60.40.10.10.1.1.1.113	2a1wI02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.114	3difB02
2.60.40.10.10.1.1.1.115	3difD02
2.60.40.10.10.1.1.1.116	1jhkH02
2.60.40.10.10.1.1.1.117	1i9iH02
2.60.40.10.10.1.1.1.118	1rihH02
2.60.40.10.10.1.1.1.119	1xf4B02
2.60.40.10.10.1.1.1.120	1xf4H02
2.60.40.10.10.1.1.1.121	3i02B02
2.60.40.10.10.1.1.1.122	2or9I02
2.60.40.10.10.1.1.1.123	2adgB02
2.60.40.10.10.1.1.1.124	1f4yH02
2.60.40.10.10.1.1.1.125	1qfuH02
2.60.40.10.10.1.1.1.126	1v7mH02
2.60.40.10.10.1.1.1.127	1v7mI02
2.60.40.10.10.1.1.1.128	3i2cH02
2.60.40.10.10.1.1.1.129	2oz4H02
2.60.40.10.10.1.1.1.130	1r0aH02
2.60.40.10.10.1.1.1.131	2nr6D02
2.60.40.10.10.1.1.1.132	2nr6F02
2.60.40.10.10.1.1.1.133	2or9H02
2.60.40.10.10.1.1.1.134	3i02D02
2.60.40.10.10.1.1.1.135	3ks0H02
2.60.40.10.10.1.1.1.136	3ks0K02
2.60.40.10.10.1.1.1.137	1jnlH02	Mus musculus, Igh protein
2.60.40.10.10.1.1.1.138	2adiB02
2.60.40.10.10.1.1.1.139	1e6jH02	Igh protein, Mus musculus
2.60.40.10.10.1.1.1.140	1xctB02
2.60.40.10.10.1.1.1.141	1xctD02
2.60.40.10.10.1.1.1.142	1ahwB02
2.60.40.10.10.1.1.1.143	1ahwE02
2.60.40.10.10.1.1.1.144	1n6qH02
2.60.40.10.10.1.1.1.145	3cvhH02
2.60.40.10.10.1.1.1.146	2adjB02
2.60.40.10.10.1.1.1.147	1n5yH02
2.60.40.10.10.1.1.1.148	1t03H02
2.60.40.10.10.1.1.1.149	3cvhQ02
2.60.40.10.10.1.1.1.150	1jnnH02	Igh protein, Mus musculus
2.60.40.10.10.1.1.1.151	2zjsH02
2.60.40.10.10.1.1.1.152	1z3gH02
2.60.40.10.10.1.1.1.153	1z3gI02
2.60.40.10.10.1.1.1.154	1kenH02
2.60.40.10.10.1.1.1.155	1kenT02
2.60.40.10.10.1.1.1.156	1xcqB02
2.60.40.10.10.1.1.1.157	1xcqD02
2.60.40.10.10.1.1.1.158	1xcqF02
2.60.40.10.10.1.1.1.159	1xcqH02
2.60.40.10.10.1.1.1.160	1v7nH02
2.60.40.10.10.1.1.1.161	1v7nI02
2.60.40.10.10.1.1.1.162	1v7nJ02
2.60.40.10.10.1.1.1.163	1v7nK02
2.60.40.10.10.1.1.1.164	1afvH02
2.60.40.10.10.1.1.1.165	1afvK02
2.60.40.10.10.1.1.1.166	2dtgA02
2.60.40.10.10.1.1.1.167	1hyxH02
2.60.40.10.10.1.1.1.168	1hyyH02
2.60.40.10.10.1.1.1.169	1l7sH02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.40.10.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.60.40.10.10.1.1.1

Classification Lineage (2.60.40.10.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.60.40.10.10.1.1.1 (169)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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