S100 Family: 2.60.200.10.5.1.1.1

Representative domain: 1u7vB00

Classification Lineage (2.60.200.10.5.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.200	Tumour Suppressor Smad4
2.60.200.10		Gene3D
2.60.200.10.5
2.60.200.10.5.1
2.60.200.10.5.1.1
2.60.200.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	4

Non-Redundant Representatives (4)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.60.200.10.5.1.1.1 (4)

CATH code	Domain ID	Keywords
2.60.200.10.5.1.1.1.1	1u7vB00	SMAD protein signal transduction, promoter binding, response to hypoxia, SMAD protein complex assembly, positive regulation of transforming growth factor beta receptor signaling pathway, Chronic myeloid leukemia, Colorectal cancer, BMP signaling pathway, negative regulation of cell growth, Adherens junction, regulation of transforming growth factor-beta2 production, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity, activin responsive factor complex, Wnt signaling pathway, Homo sapiens, Pancreatic cancer, SMAD, mothers against DPP 4, TGF-beta signaling pathway, transforming growth factor beta receptor signaling pathway, negative regulation of transcription, DNA-dependent, Pathways in cancer, I-SMAD binding, R-SMAD binding, Mothers against decapentaplegic homolog 4, protein homodimerization activity, Cell cycle
2.60.200.10.5.1.1.1.2	1dd1A00	R-SMAD binding, I-SMAD binding, Pathways in cancer, negative regulation of transcription, DNA-dependent, Cell cycle, Mothers against decapentaplegic homolog 4, protein homodimerization activity, Wnt signaling pathway, activin responsive factor complex, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity, SMAD, mothers against DPP 4, TGF-beta signaling pathway, transforming growth factor beta receptor signaling pathway, Pancreatic cancer, Homo sapiens, Colorectal cancer, BMP signaling pathway, Chronic myeloid leukemia, negative regulation of cell growth, regulation of transforming growth factor-beta2 production, Adherens junction, response to hypoxia, SMAD protein complex assembly, SMAD protein signal transduction, promoter binding, positive regulation of transforming growth factor beta receptor signaling pathway
2.60.200.10.5.1.1.1.3	1dd1C00	activin responsive factor complex, Wnt signaling pathway, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity, SMAD, mothers against DPP 4, TGF-beta signaling pathway, transforming growth factor beta receptor signaling pathway, Homo sapiens, Pancreatic cancer, I-SMAD binding, R-SMAD binding, negative regulation of transcription, DNA-dependent, Pathways in cancer, Cell cycle, Mothers against decapentaplegic homolog 4, protein homodimerization activity, response to hypoxia, SMAD protein complex assembly, promoter binding, SMAD protein signal transduction, positive regulation of transforming growth factor beta receptor signaling pathway, Chronic myeloid leukemia, Colorectal cancer, BMP signaling pathway, negative regulation of cell growth, regulation of transforming growth factor-beta2 production, Adherens junction
2.60.200.10.5.1.1.1.4	1dd1B00	negative regulation of cell growth, Colorectal cancer, BMP signaling pathway, Chronic myeloid leukemia, regulation of transforming growth factor-beta2 production, Adherens junction, SMAD protein complex assembly, response to hypoxia, SMAD protein signal transduction, promoter binding, positive regulation of transforming growth factor beta receptor signaling pathway, R-SMAD binding, I-SMAD binding, Pathways in cancer, negative regulation of transcription, DNA-dependent, Cell cycle, protein homodimerization activity, Mothers against decapentaplegic homolog 4, Wnt signaling pathway, activin responsive factor complex, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity, SMAD, mothers against DPP 4, TGF-beta signaling pathway, transforming growth factor beta receptor signaling pathway, Pancreatic cancer, Homo sapiens

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.200.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.60.200.10.5.1.1.1

Classification Lineage (2.60.200.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.60.200.10.5.1.1.1 (4)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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