S100 Family: 2.60.120.40.3.1.1.1

Molscript image for 2tnfA00
Representative domain: 2tnfA00
PDB coordinates for domain 2tnfA00

Classification Lineage (2.60.120.40.3.1.1.1)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.120 Jelly Rolls
2.60.120.40 Gene3D
2.60.120.40.3
2.60.120.40.3.1
2.60.120.40.3.1.1
2.60.120.40.3.1.1.1

Summary of Non-Redundant Representatives
- - - - - - - - 3

S100 Count Entries in S100 Family 2.60.120.40.3.1.1.1 (3)

CATH Level CATH code Domain ID Keywords Thumbnail
2.60.120.40.3.1.1.1.1 2tnfA00 phagocytic cup, external side of plasma membrane, tumor necrosis factor superfamily, member 2, positive regulation of chronic inflammatory response to antigenic stimulus, Cytokine-cytokine receptor interaction, defense response to Gram-positive bacterium, Alzheimer's disease, Adipocytokine signaling pathway, Antigen processing and presentation, tumor necrosis factor receptor binding, RIG-I-like receptor signaling pathway, regulation of immunoglobulin secretion, positive regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of transcription from RNA polymerase II promoter, Toll-like receptor signaling pathway, Apoptosis, positive regulation of translational initiation by iron, NOD-like receptor signaling pathway, Leishmaniasis, negative regulation of growth of symbiont in host, Natural killer cell mediated cytotoxicity, positive regulation of interleukin-6 production, transformed cell apoptosis, Graft-versus-host disease, Allograft rejection, regulation of osteoclast differentiation, Fc epsilon RI signaling pathway, induction of apoptosis via death domain receptors, Chagas disease, humoral immune response, glucose metabolic process, cytokine activity, integral to plasma membrane, Type II diabetes mellitus, recycling endosome, extracellular space, Mus musculus, tumor necrosis factor-mediated signaling pathway, membrane raft, positive regulation of interferon-gamma production, positive regulation of humoral immune response mediated by circulating immunoglobulin, Hypertrophic cardiomyopathy (HCM), Systemic lupus erythematosus, TGF-beta signaling pathway, T cell receptor signaling pathway, Hematopoietic cell lineage, Asthma, regulation of branching involved in salivary gland morphogenesis, Dilated cardiomyopathy, Type I diabetes mellitus, extracellular matrix organization, organ morphogenesis, Tumor necrosis factor, stored secretory granule, positive regulation of hair follicle development, Amyotrophic lateral sclerosis (ALS), positive regulation of transcription from RNA polymerase II promoter, positive regulation of JNK cascade, JNK cascade, epithelial cell proliferation involved in salivary gland morphogenesis, MAPK signaling pathway, osteoclast differentiation Molscript image for 2tnfA00
2.60.120.40.3.1.1.1.2 2tnfB00 organ morphogenesis, Tumor necrosis factor, Type I diabetes mellitus, extracellular matrix organization, regulation of branching involved in salivary gland morphogenesis, Dilated cardiomyopathy, MAPK signaling pathway, osteoclast differentiation, positive regulation of JNK cascade, JNK cascade, epithelial cell proliferation involved in salivary gland morphogenesis, positive regulation of hair follicle development, stored secretory granule, Amyotrophic lateral sclerosis (ALS), positive regulation of transcription from RNA polymerase II promoter, Mus musculus, tumor necrosis factor-mediated signaling pathway, extracellular space, recycling endosome, Type II diabetes mellitus, Hematopoietic cell lineage, Asthma, Hypertrophic cardiomyopathy (HCM), Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, membrane raft, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of interferon-gamma production, Natural killer cell mediated cytotoxicity, Leishmaniasis, NOD-like receptor signaling pathway, negative regulation of growth of symbiont in host, humoral immune response, cytokine activity, glucose metabolic process, integral to plasma membrane, induction of apoptosis via death domain receptors, Chagas disease, Allograft rejection, regulation of osteoclast differentiation, Fc epsilon RI signaling pathway, positive regulation of interleukin-6 production, transformed cell apoptosis, Graft-versus-host disease, Alzheimer's disease, Antigen processing and presentation, Adipocytokine signaling pathway, tumor necrosis factor receptor binding, tumor necrosis factor superfamily, member 2, positive regulation of chronic inflammatory response to antigenic stimulus, Cytokine-cytokine receptor interaction, defense response to Gram-positive bacterium, external side of plasma membrane, phagocytic cup, positive regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of transcription from RNA polymerase II promoter, Apoptosis, Toll-like receptor signaling pathway, positive regulation of translational initiation by iron, RIG-I-like receptor signaling pathway, regulation of immunoglobulin secretion Molscript image for 2tnfB00
2.60.120.40.3.1.1.1.3 2tnfC00 regulation of branching involved in salivary gland morphogenesis, Dilated cardiomyopathy, Type I diabetes mellitus, extracellular matrix organization, organ morphogenesis, Tumor necrosis factor, positive regulation of hair follicle development, stored secretory granule, Amyotrophic lateral sclerosis (ALS), positive regulation of transcription from RNA polymerase II promoter, positive regulation of JNK cascade, JNK cascade, epithelial cell proliferation involved in salivary gland morphogenesis, MAPK signaling pathway, osteoclast differentiation, Type II diabetes mellitus, recycling endosome, extracellular space, Mus musculus, tumor necrosis factor-mediated signaling pathway, membrane raft, positive regulation of interferon-gamma production, positive regulation of humoral immune response mediated by circulating immunoglobulin, Systemic lupus erythematosus, Hypertrophic cardiomyopathy (HCM), TGF-beta signaling pathway, T cell receptor signaling pathway, Hematopoietic cell lineage, Asthma, NOD-like receptor signaling pathway, Leishmaniasis, negative regulation of growth of symbiont in host, Natural killer cell mediated cytotoxicity, transformed cell apoptosis, positive regulation of interleukin-6 production, Graft-versus-host disease, Allograft rejection, regulation of osteoclast differentiation, Fc epsilon RI signaling pathway, induction of apoptosis via death domain receptors, Chagas disease, humoral immune response, cytokine activity, glucose metabolic process, integral to plasma membrane, phagocytic cup, external side of plasma membrane, tumor necrosis factor superfamily, member 2, positive regulation of chronic inflammatory response to antigenic stimulus, Cytokine-cytokine receptor interaction, defense response to Gram-positive bacterium, Alzheimer's disease, Antigen processing and presentation, Adipocytokine signaling pathway, tumor necrosis factor receptor binding, RIG-I-like receptor signaling pathway, regulation of immunoglobulin secretion, negative regulation of transcription from RNA polymerase II promoter, positive regulation of I-kappaB kinase/NF-kappaB cascade, Toll-like receptor signaling pathway, Apoptosis, positive regulation of translational initiation by iron Molscript image for 2tnfC00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.60.120.40.3.1.1.1