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CATH Superfamily 2.60.120.1030

Clp1, DNA binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Clp1, DNA binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Clp1, DNA binding domain

Structural domains comprising this superfamily share the structure of the N-terminal DNA binding domain of the he human cleavage and polyadenylation factor I subunit Clp1, highly conserved in eukaryotic organisms. Both human Clp1 (hsClp1) and Saccharomyces cerevisiae Clp1 (scClp1) were identified as components of the pre-mRNA 3end-processing machinery. Whereas hsClp1 was shown to also be part of the tRNA endonuclease complex, scClp1 exclusively contributes to mRNA maturation and appears to be enzymatically inactive. Clp1 is a three domain protein and this entry is focused on the N-terminal domain (NtD) involved in DNA binding PMID:24813946, PMID:24508575.

GO Diversity

Unique GO annotations
33 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1373 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 16
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 12
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 13
Function
Unique EC: 1
Unique GO: 33
Taxonomy
Unique Species: 1373
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