S100 Family: 2.40.50.100.12.1.1.1

Representative domain: 2awnB02

Classification Lineage (2.40.50.100.12.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
2.40.50.100		Gene3D
2.40.50.100.12
2.40.50.100.12.1
2.40.50.100.12.1.1
2.40.50.100.12.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.50.100.12.1.1.1 (20)

CATH code	Domain ID	Keywords
2.40.50.100.12.1.1.1.1	2awnB02	Maltose-transporting ATPase., maltose-transporting ATPase activity, maltodextrin transport, Escherichia coli K-12, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, maltooligosaccharide-importing ATPase activity, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltose transport
2.40.50.100.12.1.1.1.2	1q12A03	maltose transport, maltooligosaccharide-importing ATPase activity, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], Escherichia coli K-12, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Maltose-transporting ATPase., maltose-transporting ATPase activity, maltodextrin transport
2.40.50.100.12.1.1.1.3	1q12B03	maltose transport, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, maltooligosaccharide-importing ATPase activity, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Escherichia coli K-12, maltodextrin transport, maltose-transporting ATPase activity, Maltose-transporting ATPase.
2.40.50.100.12.1.1.1.4	1q12C03	maltose transport, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltooligosaccharide-importing ATPase activity, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Escherichia coli K-12, maltose-transporting ATPase activity, maltodextrin transport, Maltose-transporting ATPase.
2.40.50.100.12.1.1.1.5	1q12D03	Maltose-transporting ATPase., maltose-transporting ATPase activity, maltodextrin transport, Escherichia coli K-12, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, maltooligosaccharide-importing ATPase activity, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltose transport
2.40.50.100.12.1.1.1.6	3gd7A02	maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], respiratory gaseous exchange, ATP-binding cassette (ABC) transporter complex, ATP binding, maltooligosaccharide-importing ATPase activity, Cystic fibrosis transmembrane conductance regulator, maltose transport, Homo sapiens, Channel-conductance-controlling ATPase., ATP-binding cassette, subfamily C (CFTR/MRP), member 7, ATP-binding and phosphorylation-dependent chloride channel activity, maltodextrin transport, maltose-transporting ATPase activity, PDZ domain binding, Maltose-transporting ATPase., apical plasma membrane, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, enzyme binding, Vibrio cholerae infection, Escherichia coli K-12, early endosome
2.40.50.100.12.1.1.1.7	3gd7B02	Vibrio cholerae infection, early endosome, Escherichia coli K-12, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, enzyme binding, PDZ domain binding, apical plasma membrane, Maltose-transporting ATPase., Homo sapiens, ATP-binding cassette, subfamily C (CFTR/MRP), member 7, maltodextrin transport, ATP-binding and phosphorylation-dependent chloride channel activity, Channel-conductance-controlling ATPase., maltose-transporting ATPase activity, maltose transport, Cystic fibrosis transmembrane conductance regulator, maltooligosaccharide-importing ATPase activity, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], respiratory gaseous exchange, ATP-binding cassette (ABC) transporter complex, ATP binding
2.40.50.100.12.1.1.1.8	3gd7C02	ATP-binding cassette (ABC) transporter complex, ATP binding, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], respiratory gaseous exchange, maltooligosaccharide-importing ATPase activity, Cystic fibrosis transmembrane conductance regulator, maltose transport, maltose-transporting ATPase activity, Homo sapiens, ATP-binding cassette, subfamily C (CFTR/MRP), member 7, maltodextrin transport, ATP-binding and phosphorylation-dependent chloride channel activity, Channel-conductance-controlling ATPase., PDZ domain binding, apical plasma membrane, Maltose-transporting ATPase., enzyme binding, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, early endosome, Escherichia coli K-12, Vibrio cholerae infection
2.40.50.100.12.1.1.1.9	3gd7D02	maltooligosaccharide-importing ATPase activity, ATP binding, ATP-binding cassette (ABC) transporter complex, respiratory gaseous exchange, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltose transport, Cystic fibrosis transmembrane conductance regulator, Maltose-transporting ATPase., apical plasma membrane, PDZ domain binding, maltose-transporting ATPase activity, Channel-conductance-controlling ATPase., ATP-binding cassette, subfamily C (CFTR/MRP), member 7, ATP-binding and phosphorylation-dependent chloride channel activity, maltodextrin transport, Homo sapiens, Escherichia coli K-12, early endosome, Vibrio cholerae infection, enzyme binding, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK
2.40.50.100.12.1.1.1.10	1q1bA03	maltose transport, maltooligosaccharide-importing ATPase activity, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], Escherichia coli K-12, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Maltose-transporting ATPase., maltose-transporting ATPase activity, maltodextrin transport
2.40.50.100.12.1.1.1.11	1q1bB03	maltooligosaccharide-importing ATPase activity, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, maltose transport, Maltose-transporting ATPase., maltodextrin transport, maltose-transporting ATPase activity, Escherichia coli K-12, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK
2.40.50.100.12.1.1.1.12	1q1bC03	maltose transport, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, maltooligosaccharide-importing ATPase activity, ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Escherichia coli K-12, maltodextrin transport, maltose-transporting ATPase activity, Maltose-transporting ATPase.
2.40.50.100.12.1.1.1.13	1q1bD03	maltose-transporting ATPase activity, maltodextrin transport, Maltose-transporting ATPase., ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Escherichia coli K-12, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltooligosaccharide-importing ATPase activity, maltose transport
2.40.50.100.12.1.1.1.14	2awoA02	ABC transporters, Maltose/maltodextrin import ATP-binding protein MalK, Escherichia coli K-12, maltose-transporting ATPase activity, maltodextrin transport, Maltose-transporting ATPase., maltose transport, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltooligosaccharide-importing ATPase activity
2.40.50.100.12.1.1.1.15	2awoB02	maltose transport, maltooligosaccharide-importing ATPase activity, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, Escherichia coli K-12, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Maltose-transporting ATPase., maltodextrin transport, maltose-transporting ATPase activity
2.40.50.100.12.1.1.1.16	2awoC02	ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltooligosaccharide-importing ATPase activity, maltose transport, maltose-transporting ATPase activity, maltodextrin transport, Maltose-transporting ATPase., Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Escherichia coli K-12
2.40.50.100.12.1.1.1.17	2r6gA02	maltodextrin transport, maltose-transporting ATPase activity, Maltose-transporting ATPase., Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Escherichia coli K-12, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, maltooligosaccharide-importing ATPase activity, maltose transport
2.40.50.100.12.1.1.1.18	2r6gB02	Escherichia coli K-12, Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Maltose-transporting ATPase., maltose-transporting ATPase activity, maltodextrin transport, maltose transport, maltooligosaccharide-importing ATPase activity, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19]
2.40.50.100.12.1.1.1.19	1q1eA03	Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Escherichia coli K-12, maltodextrin transport, maltose-transporting ATPase activity, Maltose-transporting ATPase., maltose transport, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], ATP-binding cassette (ABC) transporter complex, maltooligosaccharide-importing ATPase activity
2.40.50.100.12.1.1.1.20	1q1eB03	Maltose/maltodextrin import ATP-binding protein MalK, ABC transporters, Escherichia coli K-12, maltose-transporting ATPase activity, maltodextrin transport, Maltose-transporting ATPase., maltose transport, ATP-binding cassette (ABC) transporter complex, maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19], maltooligosaccharide-importing ATPase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.50.100.12.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.50.100.12.1.1.1

Classification Lineage (2.40.50.100.12.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.50.100.12.1.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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