S100 Family: 2.40.50.100.10.1.1.1

Representative domain: 2a6hC05

Classification Lineage (2.40.50.100.10.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
2.40.50.100		Gene3D
2.40.50.100.10
2.40.50.100.10.1
2.40.50.100.10.1.1
2.40.50.100.10.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	28

Non-Redundant Representatives (28)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.50.100.10.1.1.1 (28)

CATH code	Domain ID	Keywords
2.40.50.100.10.1.1.1.1	2a6hC05	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, protein binding, Metabolic pathways
2.40.50.100.10.1.1.1.2	2a6hM05	Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.3	2be5C05	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, protein binding, Metabolic pathways
2.40.50.100.10.1.1.1.4	2be5M05	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, protein binding, Metabolic pathways
2.40.50.100.10.1.1.1.5	2a68C05	DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta, RNA polymerase
2.40.50.100.10.1.1.1.6	2a68M05	Metabolic pathways, protein binding, RNA polymerase, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase., Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.40.50.100.10.1.1.1.7	2a69C05	DNA-directed RNA polymerase., Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Metabolic pathways, protein binding, DNA-directed RNA polymerase subunit beta, RNA polymerase
2.40.50.100.10.1.1.1.8	2a69M05	DNA-directed RNA polymerase., Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Metabolic pathways, protein binding, DNA-directed RNA polymerase subunit beta, RNA polymerase
2.40.50.100.10.1.1.1.9	1iw7M05	Thermus thermophilus HB8, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., RNA polymerase, DNA-directed RNA polymerase subunit beta, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.10	1smyC05	RNA polymerase, DNA-directed RNA polymerase subunit beta, protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase.
2.40.50.100.10.1.1.1.11	1smyM05	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, protein binding, Metabolic pathways
2.40.50.100.10.1.1.1.12	2a6eC05	Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.13	2a6eM05	DNA-directed RNA polymerase., Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Metabolic pathways, protein binding, RNA polymerase, DNA-directed RNA polymerase subunit beta
2.40.50.100.10.1.1.1.14	2o5iC05	Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., RNA polymerase, DNA-directed RNA polymerase subunit beta, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.15	2o5iM05	RNA polymerase, DNA-directed RNA polymerase subunit beta, protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase.
2.40.50.100.10.1.1.1.16	1iw7C05	Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., RNA polymerase, DNA-directed RNA polymerase subunit beta, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.17	1zyrC05	DNA-directed RNA polymerase., Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Metabolic pathways, protein binding, DNA-directed RNA polymerase subunit beta, RNA polymerase
2.40.50.100.10.1.1.1.18	1zyrM05	Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.19	3eqlC05	DNA-directed RNA polymerase subunit beta, RNA polymerase, protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase.
2.40.50.100.10.1.1.1.20	3eqlM05	Metabolic pathways, protein binding, RNA polymerase, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase., Thermus thermophilus HB8, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.40.50.100.10.1.1.1.21	2cw0C05	Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta, RNA polymerase, Metabolic pathways, protein binding
2.40.50.100.10.1.1.1.22	2cw0M05	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Thermus thermophilus HB8, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase., RNA polymerase, DNA-directed RNA polymerase subunit beta, protein binding, Metabolic pathways
2.40.50.100.10.1.1.1.23	2o5jC05	Metabolic pathways, protein binding, DNA-directed RNA polymerase subunit beta, RNA polymerase, DNA-directed RNA polymerase., Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.40.50.100.10.1.1.1.24	2o5jM05	protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta, RNA polymerase, DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Pyrimidine metabolism, Purine metabolism, Thermus thermophilus HB8
2.40.50.100.10.1.1.1.25	2ppbC05	Metabolic pathways, protein binding, RNA polymerase, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase., Thermus thermophilus HB8, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.40.50.100.10.1.1.1.26	2ppbM05	DNA-directed RNA polymerase., DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], Purine metabolism, Pyrimidine metabolism, Thermus thermophilus HB8, protein binding, Metabolic pathways, DNA-directed RNA polymerase subunit beta, RNA polymerase
2.40.50.100.10.1.1.1.27	3dxjC05	Metabolic pathways, protein binding, RNA polymerase, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase., Thermus thermophilus HB8, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.40.50.100.10.1.1.1.28	3dxjM05	RNA polymerase, DNA-directed RNA polymerase subunit beta, Metabolic pathways, protein binding, Thermus thermophilus HB8, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase subunit beta [EC:2.7.7.6], DNA-directed RNA polymerase.

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.50.100.10.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.50.100.10.1.1.1

Classification Lineage (2.40.50.100.10.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.50.100.10.1.1.1 (28)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts