S100 Family: 2.40.30.10.8.1.1.1

Representative domain: 2bmwA01

Classification Lineage (2.40.30.10.8.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.30	Elongation Factor Tu (Ef-tu); domain 3
2.40.30.10	Translation factors	Gene3D
2.40.30.10.8
2.40.30.10.8.1
2.40.30.10.8.1.1
2.40.30.10.8.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.30.10.8.1.1.1 (20)

CATH code	Domain ID	Keywords
2.40.30.10.8.1.1.1.1	2bmwA01	NADP or NADPH binding, protein binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, Nostoc sp. PCC 7119, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding
2.40.30.10.8.1.1.1.2	1ogiA01	ferredoxin-NADP+ reductase activity, oxidation-reduction process, protein binding, NADP or NADPH binding, Nostoc sp. PCC 7119, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding
2.40.30.10.8.1.1.1.3	1ogjA01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, NADP or NADPH binding, protein binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.4	1w34A01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, protein binding, NADP or NADPH binding, oxidation-reduction process, ferredoxin-NADP+ reductase activity, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.5	1b2rA01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, NADP or NADPH binding, protein binding, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.6	1w35A01	flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., Nostoc sp. PCC 7119, NADP or NADPH binding, protein binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process
2.40.30.10.8.1.1.1.7	2vyqA01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, oxidation-reduction process, ferredoxin-NADP+ reductase activity, protein binding, NADP or NADPH binding, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.8	2vzlA01	Nostoc sp. PCC 7119, protein binding, NADP or NADPH binding, oxidation-reduction process, ferredoxin-NADP+ reductase activity, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.9	2x3uA01	Nostoc sp. PCC 7119, oxidation-reduction process, ferredoxin-NADP+ reductase activity, protein binding, NADP or NADPH binding, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.10	1queA01	oxidation-reduction process, ferredoxin-NADP+ reductase activity, NADP or NADPH binding, protein binding, Nostoc sp. PCC 7119, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding
2.40.30.10.8.1.1.1.11	1gjrA01	flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., Nostoc sp. PCC 7119, NADP or NADPH binding, protein binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process
2.40.30.10.8.1.1.1.12	1h42A01	flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., Nostoc sp. PCC 7119, NADP or NADPH binding, protein binding, oxidation-reduction process, ferredoxin-NADP+ reductase activity
2.40.30.10.8.1.1.1.13	1qufA01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, protein binding, NADP or NADPH binding, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.14	1bjkA01	Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., flavin adenine dinucleotide binding, protein binding, NADP or NADPH binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, Nostoc sp. PCC 7119
2.40.30.10.8.1.1.1.15	1bqeA01	flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., Nostoc sp. PCC 7119, ferredoxin-NADP+ reductase activity, oxidation-reduction process, protein binding, NADP or NADPH binding
2.40.30.10.8.1.1.1.16	1gr1A01	Nostoc sp. PCC 7119, NADP or NADPH binding, protein binding, oxidation-reduction process, ferredoxin-NADP+ reductase activity, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.17	1ewyA01	Nostoc sp. PCC 7119, protein binding, NADP or NADPH binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.18	1ewyB01	Nostoc sp. PCC 7119, oxidation-reduction process, ferredoxin-NADP+ reductase activity, protein binding, NADP or NADPH binding, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.19	1w87A01	Nostoc sp. PCC 7119, protein binding, NADP or NADPH binding, ferredoxin-NADP+ reductase activity, oxidation-reduction process, flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase.
2.40.30.10.8.1.1.1.20	1w87B01	flavin adenine dinucleotide binding, Ferredoxin--NADP reductase, Ferredoxin--NADP(+) reductase., Nostoc sp. PCC 7119, ferredoxin-NADP+ reductase activity, oxidation-reduction process, NADP or NADPH binding, protein binding

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.30.10.8.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.30.10.8.1.1.1

Classification Lineage (2.40.30.10.8.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.30.10.8.1.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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