The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"T3SS negative regulator GrlR
".
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"The locus of enterocyte effacement (LEE) is essential for virulence of enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC). It is comprised of 41 proteins which encode for T3SS proteins in addition to three associated regulators: Ler, GrlA and GrlR. GrlA positively regulates the expression of ler, the first gene in the LEE1 operon, which in turn regulates the expression of various downstream genes involved in T3SS biogenesis. GrlR binds directly to GrlA and functions as an anti-regulator PMID:24092262.
| Structures | |
|---|---|
| Domains: | 6 |
| Domain clusters (>95% seq id): | 2 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 0 |
| Function | |
| Unique EC: | |
| Unique GO: | |
| Taxonomy | |
| Unique Species: | 286 |