S95 Family: 2.40.10.10.67.1.1

Representative domain: 2qf3B02

Classification Lineage (2.40.10.10.67.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.67
2.40.10.10.67.1
2.40.10.10.67.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	23	37

Non-Redundant Representatives (23)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Family Entries in S95 Family 2.40.10.10.67.1.1 (23)

CATH code	Representative Domain	Representative Keywords	Number of Domains
2.40.10.10.67.1.1.1	2qf3B02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	15
2.40.10.10.67.1.1.2	2rceB02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.3	2rceG02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.4	2rceC02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.5	2rceA02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.6	2rceF02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.7	2rceD02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.8	2rceH02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.9	2qf0B02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.10	2qf0C02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.11	2qf0F02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.12	2rceE02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.13	2qf0H02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.14	2rceI02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.15	2qf0G02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.16	2qf0D02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.17	2qf0A02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.18	2qf0E02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.19	3b8jA02	Protease degSSerine endopeptidases.Protein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12	1
2.40.10.10.67.1.1.20	2qf0I02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.21	1sotA02	Escherichia coli O157:H7Protease degSSerine endopeptidases.Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.22	1sotC02	Protease degSEscherichia coli O157:H7Serine endopeptidases.Serine protease DegS [EC:3.4.21.-]	1
2.40.10.10.67.1.1.23	2qgrA02	Protease degSSerine endopeptidases.Protein bindingEscherichia coli K-12Serine protease DegS [EC:3.4.21.-]	1

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.10.10.67.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S95 Family: 2.40.10.10.67.1.1

Classification Lineage (2.40.10.10.67.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Family Entries in S95 Family 2.40.10.10.67.1.1 (23)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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