S100 Family: 2.40.10.10.18.1.1.1

Representative domain: 2jkhA02

Classification Lineage (2.40.10.10.18.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.18
2.40.10.10.18.1
2.40.10.10.18.1.1
2.40.10.10.18.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	110

Non-Redundant Representatives (110)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.10.10.18.1.1.1 (110)

CATH code	Domain ID	Keywords
2.40.10.10.18.1.1.1.1	2jkhA02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.2	2pr3A02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.3	3kl6A02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.4	3ffgA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.5	2vwoA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.6	2vwnA02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa.
2.40.10.10.18.1.1.1.7	3cenA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity
2.40.10.10.18.1.1.1.8	2xbvA02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.9	2p3uB02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.10	2xc4A02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.11	2xc5A02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.12	2xbwA02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.13	2vh0A02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.14	2uwpA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.15	2vvvA02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.16	2vwlA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.17	1c5mD02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.18	3k9xB02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.19	3k9xD02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.20	1z6eA02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.21	2p94A02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.22	2uwoA02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.23	2xbxA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.24	2j4iA02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.25	1g2lA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.26	2p93A02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6]
2.40.10.10.18.1.1.1.27	2q1jA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.28	2uwlA02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.29	2w3iA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.30	1fjsA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.31	2bokA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.32	2vvcA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.33	2xbyA02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.34	1hcgA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.35	1lpgB02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.36	2p3tB02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.37	2vh6A02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.38	2j34A02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.39	2j95A02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.40	2vwmA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.41	2xc0A02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.42	2j2uA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity
2.40.10.10.18.1.1.1.43	1nfuA02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.44	2w3kA02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.45	3hptB02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.46	3hptD02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.47	2w26A02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.48	1f0rA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.49	1f0sA02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6]
2.40.10.10.18.1.1.1.50	1ksnA02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.51	1nfwA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.52	1nfyA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.53	2cjiA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.54	2g00A02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.55	2j38A02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.56	2j94A02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.57	1mq5A02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.58	1mq6A02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.59	2ei8A02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.60	1nfxA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.61	2bohB02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.62	3ensB02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6]
2.40.10.10.18.1.1.1.63	3ensD02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.64	1ezqA02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.65	1lpkB02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.66	2bq7B02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.67	2fzzA02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.68	2p95A02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.69	3cs7A02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.70	3kqcA02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.71	2vvcB02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.72	2vwmB02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity
2.40.10.10.18.1.1.1.73	1v3xA02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.74	2d1jA02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.75	2h9eH02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.76	3kqbA02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.77	1xkaC02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.78	2p16A02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.79	2phbA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.80	2ra0A02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.81	2vvuA02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.82	1wu1A02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.83	2ei6A02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity
2.40.10.10.18.1.1.1.84	2ei7A02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa.
2.40.10.10.18.1.1.1.85	3kqeA02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.86	1xkbC02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.87	1lpzB02	Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.88	1xkbD02	positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.89	1iqgA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.90	1iqmA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity
2.40.10.10.18.1.1.1.91	1iqnA02	Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity
2.40.10.10.18.1.1.1.92	1iqlA02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.93	1lqdB02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa.
2.40.10.10.18.1.1.1.94	2bmgB02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, Complement and coagulation cascades, positive regulation of cell migration, phospholipid binding
2.40.10.10.18.1.1.1.95	3kqdA02	Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.96	1p0sH02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X
2.40.10.10.18.1.1.1.97	1ioeA02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.98	1iqeA02	coagulation factor X [EC:3.4.21.6], protein binding, positive regulation of protein kinase B signaling cascade, Coagulation factor X, Homo sapiens, Coagulation factor Xa., serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.99	1iqiA02	positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.100	2bqwB02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades
2.40.10.10.18.1.1.1.101	1iqhA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.102	1iqjA02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding
2.40.10.10.18.1.1.1.103	1g2mA02	phospholipid binding, positive regulation of cell migration, Complement and coagulation cascades, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6]
2.40.10.10.18.1.1.1.104	2bq6B02	phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade
2.40.10.10.18.1.1.1.105	2p3fH02	serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa., positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.106	2gd4B02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa.
2.40.10.10.18.1.1.1.107	1iqfA02	protein binding, coagulation factor X [EC:3.4.21.6], positive regulation of protein kinase B signaling cascade, Homo sapiens, Coagulation factor Xa., Coagulation factor X, serine-type endopeptidase activity, positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding
2.40.10.10.18.1.1.1.108	1iqkA02	serine-type endopeptidase activity, Homo sapiens, Coagulation factor Xa., Coagulation factor X, positive regulation of protein kinase B signaling cascade, protein binding, coagulation factor X [EC:3.4.21.6], phospholipid binding, Complement and coagulation cascades, positive regulation of cell migration
2.40.10.10.18.1.1.1.109	2gd4H02	positive regulation of cell migration, Complement and coagulation cascades, phospholipid binding, positive regulation of protein kinase B signaling cascade, coagulation factor X [EC:3.4.21.6], protein binding, serine-type endopeptidase activity, Coagulation factor X, Homo sapiens, Coagulation factor Xa.
2.40.10.10.18.1.1.1.110	1kyeA02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.10.10.18.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.10.10.18.1.1.1

Classification Lineage (2.40.10.10.18.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.10.10.18.1.1.1 (110)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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