S100 Family: 2.40.10.10.1.1.1.1

Representative domain: 1gvkB02

Classification Lineage (2.40.10.10.1.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.1
2.40.10.10.1.1
2.40.10.10.1.1.1
2.40.10.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	67

Non-Redundant Representatives (67)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.10.10.1.1.1.1 (67)

CATH code	Domain ID	Keywords
2.40.10.10.1.1.1.1.1	1gvkB02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.2	1hazB02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.3	1btuA02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.4	1haxB02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.5	1qr3E02
2.40.10.10.1.1.1.1.6	2bb4A02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.7	2bd3A02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.8	2bd7A02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.9	2h1uA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.10	3e3tA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.11	1elgA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.12	1esaA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.13	1nesE02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.14	3estA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.15	1h9lB02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.16	1e36B02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.17	1e38B02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.18	1elfA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.19	1hayB02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.20	1qgfA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.21	2bd2A02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.22	2bd4A02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.23	2bd8A02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.24	2bdbA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.25	1e37B02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.26	1elcA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.27	4estE02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.28	8estE02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.29	1b0eA02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.30	1bmaA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.31	1e34B02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.32	1easA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.33	2bd5A02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.34	2bdaA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.35	2bdcA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.36	2fohA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.37	6estA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.38	7estE02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.39	1lvyA02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.40	1e35B02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.41	1fleE02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.42	1qixB02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.43	2bd9A02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.44	2foaA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.45	2fobA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.46	2fogA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.47	9estA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.48	1incA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.49	1eatA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.50	1eauA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.51	1elaA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.52	1eldE02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.53	1eleE02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.54	2fo9A02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.55	2focA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.56	2fodA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.57	1hb0B02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.58	5estE02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.59	1elbA02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.1.1.1.1.60	2foeA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.61	2fofA02	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.1.1.1.1.62	1esbA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.63	1jimA02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.64	1estA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.65	2estE02	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.1.1.1.1.66	1okxA02	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.1.1.1.1.67	1okxB02	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.10.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.10.10.1.1.1.1

Classification Lineage (2.40.10.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.10.10.1.1.1.1 (67)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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