S100 Family: 2.30.40.10.24.1.1.1

Representative domain: 1ejxC01

Classification Lineage (2.30.40.10.24.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.30	Roll
2.30.40	Urease, subunit C; domain 1
2.30.40.10	Urease, subunit C, domain 1	Gene3D
2.30.40.10.24
2.30.40.10.24.1
2.30.40.10.24.1.1
2.30.40.10.24.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	29

Non-Redundant Representatives (29)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.30.40.10.24.1.1.1 (29)

CATH code	Domain ID	Keywords
2.30.40.10.24.1.1.1.1	1ejxC01	Klebsiella aerogenes, Purine metabolism, Arginine and proline metabolism, Urease., Urease subunit alpha, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Metabolic pathways
2.30.40.10.24.1.1.1.2	1ejwC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.3	1a5mC01	Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Urease subunit alpha, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease.
2.30.40.10.24.1.1.1.4	1ejrC01	Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha, Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways
2.30.40.10.24.1.1.1.5	1ejsC01	Urease subunit alpha, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5]
2.30.40.10.24.1.1.1.6	1ejtC01	Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease., Urease subunit alpha, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Metabolic pathways
2.30.40.10.24.1.1.1.7	1ejuC01	urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Metabolic pathways, Klebsiella aerogenes, Purine metabolism, Arginine and proline metabolism, Urease., Urease subunit alpha
2.30.40.10.24.1.1.1.8	1fwaC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes, Urease subunit alpha
2.30.40.10.24.1.1.1.9	1fwbC01	Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Urease subunit alpha, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes
2.30.40.10.24.1.1.1.10	1fwcC01	Urease subunit alpha, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5]
2.30.40.10.24.1.1.1.11	1fwdC01	urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Metabolic pathways, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease., Urease subunit alpha
2.30.40.10.24.1.1.1.12	1fweC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes, Urease subunit alpha
2.30.40.10.24.1.1.1.13	1fwfC01	Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Urease subunit alpha, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease.
2.30.40.10.24.1.1.1.14	1fwgC01	Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Urease subunit alpha, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease.
2.30.40.10.24.1.1.1.15	1fwhC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes, Urease subunit alpha
2.30.40.10.24.1.1.1.16	1fwiC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.17	2kauC01	Urease subunit alpha, Klebsiella aerogenes, Purine metabolism, Arginine and proline metabolism, Urease., Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation
2.30.40.10.24.1.1.1.18	1a5kC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.19	1a5lC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.20	1fwjC01	Urease subunit alpha, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5]
2.30.40.10.24.1.1.1.21	1kraC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.22	1a5nC01	Urease subunit alpha, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes, Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5]
2.30.40.10.24.1.1.1.23	1ejvC01	Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Urease subunit alpha, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease.
2.30.40.10.24.1.1.1.24	1a5oC01	Atrazine degradation, urease alpha subunit [EC:3.5.1.5], Metabolic pathways, Arginine and proline metabolism, Urease., Klebsiella aerogenes, Purine metabolism, Urease subunit alpha
2.30.40.10.24.1.1.1.25	1ef2A01	urease alpha subunit [EC:3.5.1.5], Atrazine degradation, Metabolic pathways, Klebsiella aerogenes, Purine metabolism, Arginine and proline metabolism, Urease., Urease subunit alpha
2.30.40.10.24.1.1.1.26	1krbC01	Urease subunit alpha, Arginine and proline metabolism, Urease., Purine metabolism, Klebsiella aerogenes, Metabolic pathways, Atrazine degradation, urease alpha subunit [EC:3.5.1.5]
2.30.40.10.24.1.1.1.27	1krcC01	Urease subunit alpha, Purine metabolism, Klebsiella aerogenes, Arginine and proline metabolism, Urease., Metabolic pathways, urease alpha subunit [EC:3.5.1.5], Atrazine degradation
2.30.40.10.24.1.1.1.28	1kauC01
2.30.40.10.24.1.1.1.29	3kauC01

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.30.40.10.24.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.30.40.10.24.1.1.1

Classification Lineage (2.30.40.10.24.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.30.40.10.24.1.1.1 (29)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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