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CATH Superfamily 2.30.30.870

Pelota, domain A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Pelota, domain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Pelota, domain A

Structural domains which comprise this superfamily share the structure of the N-terminal domain of Pelota (DOM34 in yeast), a protein involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. It does so through interaction with Hbs1, a EF1-alpha-related subfamily GTPase PMID:20876129

Pelota is related to EF1-alpha with similar middle and C-terminal domains, but the N-terminal domain of Dom34 is different from that of eRF1. Pelota N-terminal domain, annotated as domain A PMID:20876129 adopts a Sm-fold that is often involved in the recognition of mRNA stem loops or in the recruitment of mRNA degradation machinery PMID:18180287.

GO Diversity

Unique GO annotations
35 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2044 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 16
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 5
Unique PDBs: 8
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 12
Function
Unique EC:
Unique GO: 35
Taxonomy
Unique Species: 2044
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