The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Thioester domain
".
2.30.30.670
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: Thioester domain
This superfamily represents the thioester domain found near the N-terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue PMID:20729215. Thioester-containing domains are unexpectedly prevalent in Gram-positive bacteria, including many clinically relevant pathogens. This suggests that thioester domains may target distinct receptors and have a widespread but currently unappreciated role in mediating pathogen adhesion to hosts PMID:26032562.
The domain is also involved in bacterial-encoded covalent binding as a new molecular principle in host-microbe interactions. Thioesters in bacterial adhesins act like 'chemical harpoons', which microbes can use to irreversibly attach themselves to molecules within their host's tissues PMID:26032562
INTERPRO:IPR013552, PFAM:PF08341,DOI:10.7554/eLife.06638,DOI:10.1074/jbc.M110.149385,DOI:10.1074/jbc.M113.523761
GO Diversity
Unique GO annotations
2 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
63 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 32 |
| Domain clusters (>95% seq id): | 4 |
| Domain clusters (>35% seq id): | 3 |
| Unique PDBs: | 8 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 1 |
| Function | |
| Unique EC: | |
| Unique GO: | 2 |
| Taxonomy | |
| Unique Species: | 63 |
