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CATH Superfamily 2.30.30.560

Major vault protein, N-terminal structural repeat domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Major vault protein, N-terminal structural repeat domain

The vault complex, with a mass of 13 MDa, is the largest ribonucleoprotein particle found in eukaryotes PMID:19779459. Although several functions have been proposed for vaults since their discovery in 1986, including roles in multidrug resistance, cell signaling, and innate immunity, their cellular function remains unclear PMID:19150846. In mammals, vaults contain three proteins: the 100-kDa major vault protein (MVP), the 193-kDa vault poly(ADP-ribosyl)ating polymerase VPARP and the 240-kDa telomerase-associated protein TEP1. Approximately 75% of the vault particle mass is due to MVP PMID:19779459. The MVP monomer folds to form structural repeat domains at the N-terminus (as shown in this family), a shoulder domain, a cap-helix and cap-ring domains.

PMID:19779459 PMID:19150846

GO Diversity

Unique GO annotations
27 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
250 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 40
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC:
Unique GO: 27
Taxonomy
Unique Species: 250