S100 Family: 2.30.30.40.18.1.1.1

Representative domain: 1ckaA00

Classification Lineage (2.30.30.40.18.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.30	Roll
2.30.30	SH3 type barrels.
2.30.30.40	SH3 Domains	Gene3D
2.30.30.40.18
2.30.30.40.18.1
2.30.30.40.18.1.1
2.30.30.40.18.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	4

Non-Redundant Representatives (4)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.30.30.40.18.1.1.1 (4)

CATH code	Domain ID	Keywords
2.30.30.40.18.1.1.1.1	1ckaA00	Insulin signaling pathway, MAPK signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, ErbB signaling pathway, Chemokine signaling pathway, Neurotrophin signaling pathway, Mus musculus, Focal adhesion, protein phosphorylated amino acid binding, proto-oncogene C-crk, Chronic myeloid leukemia, SH3/SH2 adaptor activity, Renal cell carcinoma, Fc gamma R-mediated phagocytosis, Adapter molecule crk
2.30.30.40.18.1.1.1.2	1ckbA00	Chemokine signaling pathway, Neurotrophin signaling pathway, Mus musculus, MAPK signaling pathway, Insulin signaling pathway, Regulation of actin cytoskeleton, ErbB signaling pathway, Pathways in cancer, Fc gamma R-mediated phagocytosis, Renal cell carcinoma, Adapter molecule crk, protein phosphorylated amino acid binding, Focal adhesion, Chronic myeloid leukemia, proto-oncogene C-crk, SH3/SH2 adaptor activity
2.30.30.40.18.1.1.1.3	1b07A00	MAPK signaling pathway, Insulin signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, ErbB signaling pathway, Chemokine signaling pathway, Neurotrophin signaling pathway, Mus musculus, Focal adhesion, protein phosphorylated amino acid binding, Chronic myeloid leukemia, proto-oncogene C-crk, SH3/SH2 adaptor activity, Renal cell carcinoma, Fc gamma R-mediated phagocytosis, Adapter molecule crk
2.30.30.40.18.1.1.1.4	2eywA01	Regulation of actin cytoskeleton, ErbB signaling pathway, Pathways in cancer, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Homo sapiens, SH2 domain binding, Chemokine signaling pathway, nucleus, proto-oncogene C-crk, Chronic myeloid leukemia, Focal adhesion, Adapter molecule crk, actin cytoskeleton organization, Fc gamma R-mediated phagocytosis, Renal cell carcinoma, regulation of transcription from RNA polymerase II promoter

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.30.30.40.18.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.30.30.40.18.1.1.1

Classification Lineage (2.30.30.40.18.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.30.30.40.18.1.1.1 (4)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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