S100 Family: 2.30.29.30.9.1.1.1

Representative domain: 2i5fA00

Classification Lineage (2.30.29.30.9.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.30	Roll
2.30.29	PH-domain like
2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	Gene3D
2.30.29.30.9
2.30.29.30.9.1
2.30.29.30.9.1.1
2.30.29.30.9.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	4

Non-Redundant Representatives (4)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.30.29.30.9.1.1.1 (4)

CATH code	Domain ID	Keywords
2.30.29.30.9.1.1.1.1	2i5fA00	thrombin receptor signaling pathway, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, actin cytoskeleton reorganization, regulation of cell diameter, soluble fraction, protein kinase C binding, positive regulation of actin filament bundle assembly, positive regulation of actin filament depolymerization, Homo sapiens, Pleckstrin, negative regulation of inositol phosphate biosynthetic process, membrane fraction, phosphoinositide metabolic process, hemopoietic progenitor cell differentiation, ruffle organization, ruffle membrane, positive regulation of inositol-polyphosphate 5-phosphatase activity, protein homodimerization activity, cortical actin cytoskeleton organization, integrin-mediated signaling pathway, phosphatidylinositol-3,4-bisphosphate binding
2.30.29.30.9.1.1.1.2	2i5cA00	protein kinase C binding, positive regulation of actin filament bundle assembly, positive regulation of actin filament depolymerization, regulation of cell diameter, soluble fraction, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, actin cytoskeleton reorganization, thrombin receptor signaling pathway, integrin-mediated signaling pathway, phosphatidylinositol-3,4-bisphosphate binding, ruffle membrane, positive regulation of inositol-polyphosphate 5-phosphatase activity, ruffle organization, phosphoinositide metabolic process, hemopoietic progenitor cell differentiation, protein homodimerization activity, cortical actin cytoskeleton organization, Homo sapiens, membrane fraction, Pleckstrin, negative regulation of inositol phosphate biosynthetic process
2.30.29.30.9.1.1.1.3	2i5cB00	positive regulation of actin filament depolymerization, protein kinase C binding, positive regulation of actin filament bundle assembly, soluble fraction, regulation of cell diameter, actin cytoskeleton reorganization, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, thrombin receptor signaling pathway, integrin-mediated signaling pathway, phosphatidylinositol-3,4-bisphosphate binding, cortical actin cytoskeleton organization, ruffle membrane, positive regulation of inositol-polyphosphate 5-phosphatase activity, ruffle organization, phosphoinositide metabolic process, hemopoietic progenitor cell differentiation, protein homodimerization activity, membrane fraction, Pleckstrin, negative regulation of inositol phosphate biosynthetic process, Homo sapiens
2.30.29.30.9.1.1.1.4	2i5cC00	Pleckstrin, negative regulation of inositol phosphate biosynthetic process, membrane fraction, Homo sapiens, integrin-mediated signaling pathway, phosphatidylinositol-3,4-bisphosphate binding, cortical actin cytoskeleton organization, phosphoinositide metabolic process, hemopoietic progenitor cell differentiation, positive regulation of inositol-polyphosphate 5-phosphatase activity, ruffle membrane, ruffle organization, protein homodimerization activity, actin cytoskeleton reorganization, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, thrombin receptor signaling pathway, positive regulation of actin filament depolymerization, protein kinase C binding, positive regulation of actin filament bundle assembly, soluble fraction, regulation of cell diameter

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.30.29.30.9.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.30.29.30.9.1.1.1

Classification Lineage (2.30.29.30.9.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.30.29.30.9.1.1.1 (4)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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