S100 Family: 2.20.25.10.5.1.1.1

Representative domain: 1twfI01

Classification Lineage (2.20.25.10.5.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.20	Single Sheet
2.20.25	N-terminal domain of TfIIb
2.20.25.10		Gene3D
2.20.25.10.5
2.20.25.10.5.1
2.20.25.10.5.1.1
2.20.25.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	55

Non-Redundant Representatives (55)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.20.25.10.5.1.1.1 (55)

CATH code	Domain ID	Keywords
2.20.25.10.5.1.1.1.1	1twfI01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.2	1i50I02	Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.3	1k83I02	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase
2.20.25.10.5.1.1.1.4	3cqzI01	DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism
2.20.25.10.5.1.1.1.5	2nvqI01	Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug
2.20.25.10.5.1.1.1.6	1twcI01	Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.7	1i3qI02	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.8	1twaI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.9	3houI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.10	3houU01	protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.11	1twgI01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism
2.20.25.10.5.1.1.1.12	1i6hI02	Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.13	1twhI01	Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase
2.20.25.10.5.1.1.1.14	2nvyI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.15	2nvtI01	DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism
2.20.25.10.5.1.1.1.16	3gtlI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.17	2vumI01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.18	2yu9I01	Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways
2.20.25.10.5.1.1.1.19	3hoyI01	Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.20	2e2iI01	transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism
2.20.25.10.5.1.1.1.21	3gtjI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9
2.20.25.10.5.1.1.1.22	1r9tI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.23	2e2jI01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.24	3hovI01	Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways
2.20.25.10.5.1.1.1.25	2nvxI01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism
2.20.25.10.5.1.1.1.26	3howI01	response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.27	1sfoI02	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding
2.20.25.10.5.1.1.1.28	3hoxI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9
2.20.25.10.5.1.1.1.29	3hozI01	Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9
2.20.25.10.5.1.1.1.30	3i4mI01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.31	3gtgI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.32	1wcmI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9
2.20.25.10.5.1.1.1.33	1y1vI01	DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism
2.20.25.10.5.1.1.1.34	2b63I01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.35	2ja5I01	response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.36	2ja7I01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.37	2ja7U01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism
2.20.25.10.5.1.1.1.38	2ja8I01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.39	2r7zI01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism
2.20.25.10.5.1.1.1.40	2r92I01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways
2.20.25.10.5.1.1.1.41	3gtkI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter
2.20.25.10.5.1.1.1.42	3gtmI01	protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.43	3gtqI01	response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.44	3i4nI01	Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism, RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding
2.20.25.10.5.1.1.1.45	3k7aI01	Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase
2.20.25.10.5.1.1.1.46	3fkiI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase
2.20.25.10.5.1.1.1.47	3gtpI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex
2.20.25.10.5.1.1.1.48	2e2hI01	Pyrimidine metabolism, Purine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, protein binding, response to drug, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex
2.20.25.10.5.1.1.1.49	1y1wI01	Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair
2.20.25.10.5.1.1.1.50	2ja6I01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II, core complex, Metabolic pathways, DNA-directed RNA polymerase II subunit RPB9, protein binding, response to drug, Saccharomyces cerevisiae, Pyrimidine metabolism, Purine metabolism
2.20.25.10.5.1.1.1.51	2r93I01	DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.52	3gtoI01	RNA polymerase, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, DNA-directed RNA polymerase II subunit RPB9, response to drug, protein binding, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, Metabolic pathways, Saccharomyces cerevisiae, Purine metabolism, Pyrimidine metabolism
2.20.25.10.5.1.1.1.53	3h3vJ01	response to drug, protein binding, DNA-directed RNA polymerase II subunit RPB9, Metabolic pathways, DNA-directed RNA polymerase II, core complex, transcription-coupled nucleotide-excision repair, DNA-directed RNA polymerase II subunit I, transcription initiation from RNA polymerase II promoter, RNA polymerase, Purine metabolism, Pyrimidine metabolism, Saccharomyces cerevisiae
2.20.25.10.5.1.1.1.54	1r9rI02
2.20.25.10.5.1.1.1.55	2nvsI01

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.20.25.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.20.25.10.5.1.1.1

Classification Lineage (2.20.25.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.20.25.10.5.1.1.1 (55)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts