S100 Family: 1.50.10.20.7.1.1.1

Representative domain: 1n4qB00

Classification Lineage (1.50.10.20.7.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.50	Alpha/alpha barrel
1.50.10	Glycosyltransferase
1.50.10.20		Gene3D
1.50.10.20.7
1.50.10.20.7.1
1.50.10.20.7.1.1
1.50.10.20.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	60

Non-Redundant Representatives (60)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.50.10.20.7.1.1.1 (60)

CATH code	Domain ID	Keywords
1.50.10.20.7.1.1.1.1	1n4qB00	response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.2	1n4qD00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.3	1n4qF00	response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.4	1n4qH00	Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process
1.50.10.20.7.1.1.1.5	1n4qJ00	positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus
1.50.10.20.7.1.1.1.6	1n4qL00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.7	1s64B00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.8	1s64D00	CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.9	1s64F00	Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus
1.50.10.20.7.1.1.1.10	1s64H00	response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.11	1s64J00	response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.12	1s64L00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I.
1.50.10.20.7.1.1.1.13	1n4sB00	Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus
1.50.10.20.7.1.1.1.14	1n4sD00	Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity
1.50.10.20.7.1.1.1.15	1n4sF00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.16	1n4sH00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.17	1n4sJ00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus
1.50.10.20.7.1.1.1.18	1n4sL00	positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity
1.50.10.20.7.1.1.1.19	1n4pB00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.20	1n4pD00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.21	1n4pF00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.22	1n4pH00	CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.23	1n4pJ00	positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity
1.50.10.20.7.1.1.1.24	1n4pL00	response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.25	1tnoB00	CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation
1.50.10.20.7.1.1.1.26	1tnoD00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.27	1tnoF00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus
1.50.10.20.7.1.1.1.28	1tnoH00	Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process
1.50.10.20.7.1.1.1.29	1tnoJ00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus
1.50.10.20.7.1.1.1.30	1tnoL00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.31	1tnuB00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I.
1.50.10.20.7.1.1.1.32	1tnuD00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus
1.50.10.20.7.1.1.1.33	1tnuF00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus
1.50.10.20.7.1.1.1.34	1tnuH00	CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process
1.50.10.20.7.1.1.1.35	1tnuJ00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.36	1tnuL00	CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.37	1tnyB00	CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation
1.50.10.20.7.1.1.1.38	1tnyD00	CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.39	1tnyF00	Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus
1.50.10.20.7.1.1.1.40	1tnyH00	positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus
1.50.10.20.7.1.1.1.41	1tnyJ00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.42	1tnyL00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus
1.50.10.20.7.1.1.1.43	1n4rB00	response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle
1.50.10.20.7.1.1.1.44	1n4rD00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus
1.50.10.20.7.1.1.1.45	1n4rF00	CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.46	1n4rH00	Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation
1.50.10.20.7.1.1.1.47	1n4rJ00	response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.48	1n4rL00	response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle
1.50.10.20.7.1.1.1.49	1tnbB00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.50	1tnbD00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.51	1tnbF00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.52	1tnbH00	CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process
1.50.10.20.7.1.1.1.53	1tnbJ00	CAAX-protein geranylgeranyltransferase complex, protein binding, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, positive regulation of cell cycle, response to protein stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to cytokine stimulus, Protein geranylgeranyltransferase type I., geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59]
1.50.10.20.7.1.1.1.54	1tnbL00	Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle, CAAX-protein geranylgeranyltransferase complex, protein binding
1.50.10.20.7.1.1.1.55	1tnzB00	response to protein stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, Protein geranylgeranyltransferase type I., response to cytokine stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], CAAX-protein geranylgeranyltransferase complex, protein binding, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell cycle
1.50.10.20.7.1.1.1.56	1tnzD00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], response to cytokine stimulus, Protein geranylgeranyltransferase type I., CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, positive regulation of cell cycle, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, positive regulation of cell proliferation, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.57	1tnzF00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.58	1tnzH00	positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, Rattus norvegicus, CAAX-protein geranylgeranyltransferase activity, response to protein stimulus
1.50.10.20.7.1.1.1.59	1tnzJ00	geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, protein binding, CAAX-protein geranylgeranyltransferase complex
1.50.10.20.7.1.1.1.60	1tnzL00	protein binding, CAAX-protein geranylgeranyltransferase complex, positive regulation of cell cycle, positive regulation of cell proliferation, Geranylgeranyl transferase type-1 subunit beta, negative regulation of nitric-oxide synthase 2 biosynthetic process, CAAX-protein geranylgeranyltransferase activity, Rattus norvegicus, response to protein stimulus, geranylgeranyl transferase type-1 subunit beta [EC:2.5.1.59], Protein geranylgeranyltransferase type I., response to cytokine stimulus

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.50.10.20.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.50.10.20.7.1.1.1

Classification Lineage (1.50.10.20.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.50.10.20.7.1.1.1 (60)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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