S100 Family: 1.25.10.10.2.1.1.1

Representative domain: 1jdhA00

Classification Lineage (1.25.10.10.2.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.25	Alpha Horseshoe
1.25.10	Leucine-rich Repeat Variant
1.25.10.10	Leucine-rich Repeat Variant	Gene3D
1.25.10.10.2
1.25.10.10.2.1
1.25.10.10.2.1.1
1.25.10.10.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	6

Non-Redundant Representatives (6)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.25.10.10.2.1.1.1 (6)

CATH code	Domain ID	Keywords
1.25.10.10.2.1.1.1.1	1jdhA00	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex, catenin complex, Homo sapiens, Melanogenesis, protein phosphatase binding, catenin (cadherin-associated protein), beta 1, epithelial to mesenchymal transition, Leukocyte transendothelial migration, cellular response to growth factor stimulus, Wnt signaling pathway, protein C-terminus binding, Prostate cancer, Pathogenic Escherichia coli infection, kinase binding, regulation of fibroblast proliferation, Pathways in cancer, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription coactivator activity, regulation of centriole-centriole cohesion, protein-DNA complex, I-SMAD binding, regulation of angiogenesis, centrosome, Endometrial cancer, beta-catenin destruction complex, positive regulation of heparan sulfate proteoglycan biosynthetic process, alpha-catenin binding, Thyroid cancer, negative regulation of cell proliferation, perinuclear region of cytoplasm, Catenin beta-1, promoter binding, Basal cell carcinoma, lateral plasma membrane, canonical Wnt receptor signaling pathway, Adherens junction, Focal adhesion, cadherin binding, cell-cell adhesion, positive regulation of apoptosis, beta-catenin-TCF7L2 complex, Colorectal cancer, Tight junction
1.25.10.10.2.1.1.1.2	1g3jA00	canonical Wnt receptor signaling pathway, Adherens junction, cell-cell adhesion, Focal adhesion, cadherin binding, beta-catenin-TCF7L2 complex, positive regulation of apoptosis, Colorectal cancer, Tight junction, Endometrial cancer, centrosome, regulation of angiogenesis, positive regulation of heparan sulfate proteoglycan biosynthetic process, alpha-catenin binding, beta-catenin destruction complex, Thyroid cancer, negative regulation of cell proliferation, perinuclear region of cytoplasm, Catenin beta-1, promoter binding, Basal cell carcinoma, lateral plasma membrane, Prostate cancer, protein C-terminus binding, kinase binding, Pathogenic Escherichia coli infection, regulation of fibroblast proliferation, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, transcription coactivator activity, protein-DNA complex, regulation of centriole-centriole cohesion, I-SMAD binding, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex, Homo sapiens, catenin complex, Melanogenesis, protein phosphatase binding, catenin (cadherin-associated protein), beta 1, Leukocyte transendothelial migration, epithelial to mesenchymal transition, cellular response to growth factor stimulus, Wnt signaling pathway
1.25.10.10.2.1.1.1.3	1qz7A00	Tight junction, Colorectal cancer, cell-cell adhesion, Focal adhesion, cadherin binding, beta-catenin-TCF7L2 complex, positive regulation of apoptosis, canonical Wnt receptor signaling pathway, Adherens junction, Basal cell carcinoma, lateral plasma membrane, perinuclear region of cytoplasm, Catenin beta-1, promoter binding, Thyroid cancer, negative regulation of cell proliferation, Endometrial cancer, regulation of angiogenesis, centrosome, beta-catenin destruction complex, alpha-catenin binding, positive regulation of heparan sulfate proteoglycan biosynthetic process, protein-DNA complex, regulation of centriole-centriole cohesion, I-SMAD binding, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, transcription coactivator activity, kinase binding, Pathogenic Escherichia coli infection, regulation of fibroblast proliferation, Prostate cancer, protein C-terminus binding, cellular response to growth factor stimulus, Wnt signaling pathway, Leukocyte transendothelial migration, epithelial to mesenchymal transition, Melanogenesis, protein phosphatase binding, catenin (cadherin-associated protein), beta 1, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex, Homo sapiens, catenin complex
1.25.10.10.2.1.1.1.4	1lujA00	Tight junction, Colorectal cancer, positive regulation of apoptosis, beta-catenin-TCF7L2 complex, Focal adhesion, cadherin binding, cell-cell adhesion, Adherens junction, canonical Wnt receptor signaling pathway, Basal cell carcinoma, lateral plasma membrane, Catenin beta-1, promoter binding, perinuclear region of cytoplasm, Thyroid cancer, negative regulation of cell proliferation, alpha-catenin binding, beta-catenin destruction complex, positive regulation of heparan sulfate proteoglycan biosynthetic process, regulation of angiogenesis, centrosome, Endometrial cancer, I-SMAD binding, regulation of centriole-centriole cohesion, protein-DNA complex, transcription coactivator activity, Pathways in cancer, positive regulation of gene-specific transcription from RNA polymerase II promoter, regulation of fibroblast proliferation, Pathogenic Escherichia coli infection, kinase binding, protein C-terminus binding, Prostate cancer, Wnt signaling pathway, cellular response to growth factor stimulus, epithelial to mesenchymal transition, Leukocyte transendothelial migration, catenin (cadherin-associated protein), beta 1, Melanogenesis, protein phosphatase binding, catenin complex, Homo sapiens, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex
1.25.10.10.2.1.1.1.5	1th1B00	Tight junction, Colorectal cancer, positive regulation of apoptosis, beta-catenin-TCF7L2 complex, Focal adhesion, cadherin binding, cell-cell adhesion, Adherens junction, canonical Wnt receptor signaling pathway, Basal cell carcinoma, lateral plasma membrane, Catenin beta-1, promoter binding, perinuclear region of cytoplasm, Thyroid cancer, negative regulation of cell proliferation, beta-catenin destruction complex, positive regulation of heparan sulfate proteoglycan biosynthetic process, alpha-catenin binding, regulation of angiogenesis, centrosome, Endometrial cancer, I-SMAD binding, regulation of centriole-centriole cohesion, protein-DNA complex, transcription coactivator activity, Pathways in cancer, positive regulation of gene-specific transcription from RNA polymerase II promoter, regulation of fibroblast proliferation, Pathogenic Escherichia coli infection, kinase binding, protein C-terminus binding, Prostate cancer, Wnt signaling pathway, cellular response to growth factor stimulus, epithelial to mesenchymal transition, Leukocyte transendothelial migration, catenin (cadherin-associated protein), beta 1, Melanogenesis, protein phosphatase binding, catenin complex, Homo sapiens, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex
1.25.10.10.2.1.1.1.6	1th1A00	Basal cell carcinoma, lateral plasma membrane, Catenin beta-1, promoter binding, perinuclear region of cytoplasm, Thyroid cancer, negative regulation of cell proliferation, alpha-catenin binding, beta-catenin destruction complex, positive regulation of heparan sulfate proteoglycan biosynthetic process, centrosome, regulation of angiogenesis, Endometrial cancer, Tight junction, Colorectal cancer, positive regulation of apoptosis, beta-catenin-TCF7L2 complex, Focal adhesion, cadherin binding, cell-cell adhesion, Adherens junction, canonical Wnt receptor signaling pathway, Wnt signaling pathway, cellular response to growth factor stimulus, epithelial to mesenchymal transition, Leukocyte transendothelial migration, catenin (cadherin-associated protein), beta 1, Melanogenesis, protein phosphatase binding, catenin complex, Homo sapiens, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Axin-APC-beta-catenin-GSK3B complex, I-SMAD binding, regulation of centriole-centriole cohesion, protein-DNA complex, transcription coactivator activity, Pathways in cancer, positive regulation of gene-specific transcription from RNA polymerase II promoter, regulation of fibroblast proliferation, Pathogenic Escherichia coli infection, kinase binding, protein C-terminus binding, Prostate cancer

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.25.10.10.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.25.10.10.2.1.1.1

Classification Lineage (1.25.10.10.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.25.10.10.2.1.1.1 (6)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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