S100 Family: 1.20.910.10.7.1.1.1

Molscript image for 1j02A00
Representative domain: 1j02A00
PDB coordinates for domain 1j02A00

Classification Lineage (1.20.910.10.7.1.1.1)

CATH CodeLevel DescriptionLinks
1 Mainly Alpha
1.20 Up-down Bundle
1.20.910 Heme Oxygenase; Chain A
1.20.910.10 Heme Oxygenase; Chain A Gene3D
1.20.910.10.7
1.20.910.10.7.1
1.20.910.10.7.1.1
1.20.910.10.7.1.1.1

Summary of Non-Redundant Representatives
- - - - - - - - 14

S100 Count Entries in S100 Family 1.20.910.10.7.1.1.1 (14)

CATH Level CATH code Domain ID Keywords Thumbnail
1.20.910.10.7.1.1.1.1 1j02A00 endoplasmic reticulum, heme catabolic process, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, phospholipase D activity, Heme oxygenase., phospholipid metabolic process, response to hydrogen peroxide, negative regulation of transcription factor activity, caveola, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, heme oxygenase (decyclizing) activity, heme oxidation, microsome, response to hypoxia, cellular response to nutrient, small GTPase mediated signal transduction, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, regulation of blood pressure, cytosol, positive regulation of anti-apoptosis, negative regulation of mast cell degranulation, heme binding, Rattus norvegicus, Porphyrin and chlorophyll metabolism, cell death, response to estrogen stimulus, angiogenesis, heme oxygenase [EC:1.14.99.3] Molscript image for 1j02A00
1.20.910.10.7.1.1.1.2 1ix4A00 enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipase D activity, Heme oxygenase., heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, nucleolus, negative regulation of mast cell cytokine production, angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3], heme binding, negative regulation of mast cell degranulation, cell death, Porphyrin and chlorophyll metabolism, Rattus norvegicus, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, positive regulation of anti-apoptosis, regulation of blood pressure, cytosol, response to hypoxia, microsome, heme oxidation, small GTPase mediated signal transduction, cellular response to nutrient Molscript image for 1ix4A00
1.20.910.10.7.1.1.1.3 2e7eA00 angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3], negative regulation of mast cell degranulation, heme binding, Porphyrin and chlorophyll metabolism, cell death, Rattus norvegicus, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, response to hypoxia, heme oxidation, microsome, small GTPase mediated signal transduction, cellular response to nutrient, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipase D activity, Heme oxygenase., heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus Molscript image for 2e7eA00
1.20.910.10.7.1.1.1.4 1ivjA00 Heme oxygenase 1, nucleolus, negative regulation of mast cell cytokine production, heme catabolic process, endoplasmic reticulum, Heme oxygenase., phospholipase D activity, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipid metabolic process, heme oxygenase (decyclizing) activity, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, small GTPase mediated signal transduction, cellular response to nutrient, response to hypoxia, microsome, heme oxidation, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, cell death, Porphyrin and chlorophyll metabolism, Rattus norvegicus, heme binding, negative regulation of mast cell degranulation, heme oxygenase [EC:1.14.99.3], angiogenesis, response to estrogen stimulus Molscript image for 1ivjA00
1.20.910.10.7.1.1.1.5 1vgiA00 response to hydrogen peroxide, negative regulation of transcription factor activity, phospholipid metabolic process, heme oxygenase (decyclizing) activity, caveola, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, Heme oxygenase 1, nucleolus, negative regulation of mast cell cytokine production, endoplasmic reticulum, heme catabolic process, Heme oxygenase., phospholipase D activity, Rattus norvegicus, cell death, Porphyrin and chlorophyll metabolism, heme binding, negative regulation of mast cell degranulation, heme oxygenase [EC:1.14.99.3], response to estrogen stimulus, angiogenesis, cellular response to nutrient, small GTPase mediated signal transduction, microsome, heme oxidation, response to hypoxia, regulation of blood pressure, cytosol, positive regulation of anti-apoptosis, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress Molscript image for 1vgiA00
1.20.910.10.7.1.1.1.6 1ulxA00 angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3], negative regulation of mast cell degranulation, heme binding, Porphyrin and chlorophyll metabolism, cell death, Rattus norvegicus, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, response to hypoxia, heme oxidation, microsome, small GTPase mediated signal transduction, cellular response to nutrient, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipase D activity, Heme oxygenase., heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus Molscript image for 1ulxA00
1.20.910.10.7.1.1.1.7 1ix3A00 heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, phospholipase D activity, Heme oxygenase., phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, response to hypoxia, heme oxidation, microsome, small GTPase mediated signal transduction, cellular response to nutrient, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, negative regulation of mast cell degranulation, heme binding, Porphyrin and chlorophyll metabolism, cell death, Rattus norvegicus, angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3] Molscript image for 1ix3A00
1.20.910.10.7.1.1.1.8 3i9tA00 heme binding, negative regulation of mast cell degranulation, cell death, Porphyrin and chlorophyll metabolism, Rattus norvegicus, angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3], response to hypoxia, microsome, heme oxidation, small GTPase mediated signal transduction, cellular response to nutrient, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, positive regulation of anti-apoptosis, regulation of blood pressure, cytosol, phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, phospholipase D activity, Heme oxygenase. Molscript image for 3i9tA00
1.20.910.10.7.1.1.1.9 2zvuA00 negative regulation of mast cell degranulation, heme binding, Porphyrin and chlorophyll metabolism, cell death, Rattus norvegicus, angiogenesis, response to estrogen stimulus, heme oxygenase [EC:1.14.99.3], response to hypoxia, heme oxidation, microsome, small GTPase mediated signal transduction, cellular response to nutrient, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, phospholipid metabolic process, negative regulation of transcription factor activity, response to hydrogen peroxide, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, heme oxygenase (decyclizing) activity, heme catabolic process, endoplasmic reticulum, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, phospholipase D activity, Heme oxygenase. Molscript image for 2zvuA00
1.20.910.10.7.1.1.1.10 3i9uA00 Heme oxygenase., phospholipase D activity, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, endoplasmic reticulum, heme catabolic process, heme oxygenase (decyclizing) activity, caveola, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, response to hydrogen peroxide, negative regulation of transcription factor activity, phospholipid metabolic process, regulation of blood pressure, cytosol, positive regulation of anti-apoptosis, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, cellular response to nutrient, small GTPase mediated signal transduction, heme oxidation, microsome, response to hypoxia, heme oxygenase [EC:1.14.99.3], response to estrogen stimulus, angiogenesis, Rattus norvegicus, Porphyrin and chlorophyll metabolism, cell death, negative regulation of mast cell degranulation, heme binding Molscript image for 3i9uA00
1.20.910.10.7.1.1.1.11 1ubbA00 response to hydrogen peroxide, negative regulation of transcription factor activity, phospholipid metabolic process, heme oxygenase (decyclizing) activity, caveola, DNA damage response, signal transduction resulting in induction of apoptosis, enzyme binding, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, endoplasmic reticulum, heme catabolic process, Heme oxygenase., phospholipase D activity, Rattus norvegicus, Porphyrin and chlorophyll metabolism, cell death, negative regulation of mast cell degranulation, heme binding, heme oxygenase [EC:1.14.99.3], response to estrogen stimulus, angiogenesis, cellular response to nutrient, small GTPase mediated signal transduction, heme oxidation, microsome, response to hypoxia, cytosol, regulation of blood pressure, positive regulation of anti-apoptosis, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation Molscript image for 1ubbA00
1.20.910.10.7.1.1.1.12 1dveA00 positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, small GTPase mediated signal transduction, cellular response to nutrient, response to hypoxia, microsome, heme oxidation, heme oxygenase [EC:1.14.99.3], angiogenesis, response to estrogen stimulus, cell death, Porphyrin and chlorophyll metabolism, Rattus norvegicus, heme binding, negative regulation of mast cell degranulation, Heme oxygenase., phospholipase D activity, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, heme catabolic process, endoplasmic reticulum, heme oxygenase (decyclizing) activity, enzyme binding, caveola, DNA damage response, signal transduction resulting in induction of apoptosis, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipid metabolic process Molscript image for 1dveA00
1.20.910.10.7.1.1.1.13 1j2cA00 heme oxygenase (decyclizing) activity, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipid metabolic process, Heme oxygenase., phospholipase D activity, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, heme catabolic process, endoplasmic reticulum, heme oxygenase [EC:1.14.99.3], angiogenesis, response to estrogen stimulus, Porphyrin and chlorophyll metabolism, cell death, Rattus norvegicus, negative regulation of mast cell degranulation, heme binding, positive regulation of anti-apoptosis, regulation of blood pressure, cytosol, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, negative regulation of cell proliferation, small GTPase mediated signal transduction, cellular response to nutrient, response to hypoxia, heme oxidation, microsome Molscript image for 1j2cA00
1.20.910.10.7.1.1.1.14 2dy5A00 Heme oxygenase., phospholipase D activity, Heme oxygenase 1, negative regulation of mast cell cytokine production, nucleolus, heme catabolic process, endoplasmic reticulum, heme oxygenase (decyclizing) activity, enzyme binding, DNA damage response, signal transduction resulting in induction of apoptosis, caveola, negative regulation of transcription factor activity, response to hydrogen peroxide, phospholipid metabolic process, positive regulation of anti-apoptosis, cytosol, regulation of blood pressure, negative regulation of cell proliferation, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, small GTPase mediated signal transduction, cellular response to nutrient, response to hypoxia, microsome, heme oxidation, heme oxygenase [EC:1.14.99.3], angiogenesis, response to estrogen stimulus, cell death, Porphyrin and chlorophyll metabolism, Rattus norvegicus, heme binding, negative regulation of mast cell degranulation Molscript image for 2dy5A00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.20.910.10.7.1.1.1