View in Gene3D

CATH Superfamily 1.20.1250.70

Interleukin-15/Interleukin-21

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Interleukin-15/Interleukin-21
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Interleukin-15/Interleukin-21

Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cellular immune responses PMID:10689297. Structurally these proteins are short-chain 4-helical cytokines.

It is required for division of CD8+ T cells of memory phenotype, a process that is increased by inhibition of IL-2 PMID:10784451. The numbers of CD8+ memory T cells in animals may, therefore, be controlled by a balance between IL-15 and -2.

INTERPRO:IPR003443, PFAM:PF02372

GO Diversity

Unique GO annotations
61 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
213 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 23
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 2
Unique PDBs: 7
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC:
Unique GO: 61
Taxonomy
Unique Species: 213