S100 Family: 1.20.1250.10.5.1.1.1

Representative domain: 1m48B00

Classification Lineage (1.20.1250.10.5.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.20	Up-down Bundle
1.20.1250	Growth Hormone; Chain: A;
1.20.1250.10		Gene3D
1.20.1250.10.5
1.20.1250.10.5.1
1.20.1250.10.5.1.1
1.20.1250.10.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	15

Non-Redundant Representatives (15)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.20.1250.10.5.1.1.1 (15)

CATH code	Domain ID	Keywords
1.20.1250.10.5.1.1.1.1	1m48B00	growth factor activity, extracellular space, T cell differentiation, kinase activator activity, Homo sapiens, T cell receptor signaling pathway, immune response, Type I diabetes mellitus, anti-apoptosis, cell adhesion, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, Cytokine-cytokine receptor interaction, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, negative regulation of B cell apoptosis, Jak-STAT signaling pathway, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Chagas disease, cell-cell signaling, interleukin-2 receptor binding
1.20.1250.10.5.1.1.1.2	1m48A00	Jak-STAT signaling pathway, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Cytokine-cytokine receptor interaction, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, negative regulation of B cell apoptosis, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, Type I diabetes mellitus, anti-apoptosis, cell adhesion, extracellular space, growth factor activity, T cell receptor signaling pathway, immune response, T cell differentiation, kinase activator activity, Homo sapiens
1.20.1250.10.5.1.1.1.3	1m49A00	negative regulation of B cell apoptosis, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, natural killer cell activation, Interleukin-2, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, Jak-STAT signaling pathway, immune response, T cell receptor signaling pathway, kinase activator activity, Homo sapiens, T cell differentiation, extracellular space, growth factor activity, cell adhesion, anti-apoptosis, Type I diabetes mellitus
1.20.1250.10.5.1.1.1.4	1m47A00	growth factor activity, extracellular space, T cell differentiation, Homo sapiens, kinase activator activity, T cell receptor signaling pathway, immune response, Type I diabetes mellitus, anti-apoptosis, cell adhesion, Interleukin-2, natural killer cell activation, Intestinal immune network for IgA production, Cytokine-cytokine receptor interaction, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, negative regulation of B cell apoptosis, Jak-STAT signaling pathway, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, interleukin-2 receptor binding, Chagas disease, cell-cell signaling
1.20.1250.10.5.1.1.1.5	1m49B00	Type I diabetes mellitus, anti-apoptosis, cell adhesion, growth factor activity, extracellular space, T cell differentiation, kinase activator activity, Homo sapiens, T cell receptor signaling pathway, immune response, Jak-STAT signaling pathway, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, Cytokine-cytokine receptor interaction, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, negative regulation of B cell apoptosis
1.20.1250.10.5.1.1.1.6	2b5iA00	Interleukin-2, natural killer cell activation, Intestinal immune network for IgA production, Cytokine-cytokine receptor interaction, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, negative regulation of B cell apoptosis, Jak-STAT signaling pathway, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, interleukin-2 receptor binding, Chagas disease, cell-cell signaling, growth factor activity, extracellular space, T cell differentiation, Homo sapiens, kinase activator activity, T cell receptor signaling pathway, immune response, Type I diabetes mellitus, anti-apoptosis, cell adhesion
1.20.1250.10.5.1.1.1.7	1pw6B00	Jak-STAT signaling pathway, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Intestinal immune network for IgA production, natural killer cell activation, Interleukin-2, Cytokine-cytokine receptor interaction, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, negative regulation of B cell apoptosis, anti-apoptosis, Type I diabetes mellitus, cell adhesion, growth factor activity, extracellular space, kinase activator activity, Homo sapiens, T cell differentiation, immune response, T cell receptor signaling pathway
1.20.1250.10.5.1.1.1.8	1m4cB00	Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Jak-STAT signaling pathway, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, negative regulation of B cell apoptosis, Intestinal immune network for IgA production, natural killer cell activation, Interleukin-2, Cytokine-cytokine receptor interaction, cell adhesion, anti-apoptosis, Type I diabetes mellitus, kinase activator activity, Homo sapiens, T cell differentiation, immune response, T cell receptor signaling pathway, growth factor activity, extracellular space
1.20.1250.10.5.1.1.1.9	1m4cA00	Intestinal immune network for IgA production, natural killer cell activation, Interleukin-2, Cytokine-cytokine receptor interaction, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, negative regulation of B cell apoptosis, Jak-STAT signaling pathway, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, growth factor activity, extracellular space, kinase activator activity, Homo sapiens, T cell differentiation, immune response, T cell receptor signaling pathway, anti-apoptosis, Type I diabetes mellitus, cell adhesion
1.20.1250.10.5.1.1.1.10	1pw6A00	Jak-STAT signaling pathway, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Cytokine-cytokine receptor interaction, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, negative regulation of B cell apoptosis, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, Type I diabetes mellitus, anti-apoptosis, cell adhesion, extracellular space, growth factor activity, T cell receptor signaling pathway, immune response, T cell differentiation, kinase activator activity, Homo sapiens
1.20.1250.10.5.1.1.1.11	1z92A00	Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Jak-STAT signaling pathway, negative regulation of B cell apoptosis, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, Cytokine-cytokine receptor interaction, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, cell adhesion, Type I diabetes mellitus, anti-apoptosis, T cell receptor signaling pathway, immune response, T cell differentiation, kinase activator activity, Homo sapiens, extracellular space, growth factor activity
1.20.1250.10.5.1.1.1.12	1py2D00	anti-apoptosis, Type I diabetes mellitus, cell adhesion, growth factor activity, extracellular space, Homo sapiens, kinase activator activity, T cell differentiation, immune response, T cell receptor signaling pathway, Jak-STAT signaling pathway, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, interleukin-2 receptor binding, Chagas disease, cell-cell signaling, natural killer cell activation, Intestinal immune network for IgA production, Interleukin-2, Cytokine-cytokine receptor interaction, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, negative regulation of B cell apoptosis
1.20.1250.10.5.1.1.1.13	1py2A00	negative regulation of B cell apoptosis, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, natural killer cell activation, Interleukin-2, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, Jak-STAT signaling pathway, immune response, T cell receptor signaling pathway, kinase activator activity, Homo sapiens, T cell differentiation, extracellular space, growth factor activity, cell adhesion, anti-apoptosis, Type I diabetes mellitus
1.20.1250.10.5.1.1.1.14	1py2B00	growth factor activity, extracellular space, Homo sapiens, kinase activator activity, T cell differentiation, immune response, T cell receptor signaling pathway, anti-apoptosis, Type I diabetes mellitus, cell adhesion, natural killer cell activation, Intestinal immune network for IgA production, Interleukin-2, Cytokine-cytokine receptor interaction, interleukin 2, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, negative regulation of B cell apoptosis, Jak-STAT signaling pathway, Allograft rejection, positive regulation of B cell proliferation, Graft-versus-host disease, positive regulation of cell growth, interleukin-2 receptor binding, Chagas disease, cell-cell signaling
1.20.1250.10.5.1.1.1.15	1py2C00	Jak-STAT signaling pathway, Chagas disease, cell-cell signaling, interleukin-2 receptor binding, Graft-versus-host disease, positive regulation of cell growth, Allograft rejection, positive regulation of B cell proliferation, Cytokine-cytokine receptor interaction, Interleukin-2, Intestinal immune network for IgA production, natural killer cell activation, negative regulation of B cell apoptosis, Autoimmune thyroid disease, positive regulation of activated T cell proliferation, interleukin 2, Type I diabetes mellitus, anti-apoptosis, cell adhesion, extracellular space, growth factor activity, T cell receptor signaling pathway, immune response, T cell differentiation, kinase activator activity, Homo sapiens

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.20.1250.10.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.20.1250.10.5.1.1.1

Classification Lineage (1.20.1250.10.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.20.1250.10.5.1.1.1 (15)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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