S100 Family: 1.20.1250.10.2.1.1.1

Molscript image for 1lk3A00
Representative domain: 1lk3A00
PDB coordinates for domain 1lk3A00

Classification Lineage (1.20.1250.10.2.1.1.1)

CATH CodeLevel DescriptionLinks
1 Mainly Alpha
1.20 Up-down Bundle
1.20.1250 Growth Hormone; Chain: A;
1.20.1250.10 Gene3D
1.20.1250.10.2
1.20.1250.10.2.1
1.20.1250.10.2.1.1
1.20.1250.10.2.1.1.1

Summary of Non-Redundant Representatives
- - - - - - - - 5

S100 Count Entries in S100 Family 1.20.1250.10.2.1.1.1 (5)

CATH Level CATH code Domain ID Keywords Thumbnail
1.20.1250.10.2.1.1.1.1 1lk3A00 Chagas disease, negative regulation of MHC class II biosynthetic process, Allograft rejection, Jak-STAT signaling pathway, positive regulation of transcription factor activity, interleukin 10, inflammatory response, type 2 immune response, Leishmaniasis, response to glucocorticoid stimulus, receptor biosynthetic process, Interleukin-10, Autoimmune thyroid disease, leukocyte chemotaxis, Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, negative regulation of cytokine secretion involved in immune response, negative regulation of B cell proliferation, negative regulation of interleukin-6 production, Asthma, T cell receptor signaling pathway, Systemic lupus erythematosus, positive regulation of gene-specific transcription, Homo sapiens, positive regulation of B cell apoptosis, negative regulation of membrane protein ectodomain proteolysis, extracellular space, positive regulation of cytokine secretion Molscript image for 1lk3A00
1.20.1250.10.2.1.1.1.2 1lk3B00 extracellular space, negative regulation of membrane protein ectodomain proteolysis, positive regulation of cytokine secretion, Systemic lupus erythematosus, T cell receptor signaling pathway, Asthma, Homo sapiens, positive regulation of B cell apoptosis, positive regulation of gene-specific transcription, negative regulation of interleukin-6 production, Cytokine-cytokine receptor interaction, negative regulation of B cell proliferation, Intestinal immune network for IgA production, negative regulation of cytokine secretion involved in immune response, Interleukin-10, receptor biosynthetic process, leukocyte chemotaxis, Autoimmune thyroid disease, interleukin 10, inflammatory response, Jak-STAT signaling pathway, positive regulation of transcription factor activity, Leishmaniasis, response to glucocorticoid stimulus, type 2 immune response, negative regulation of MHC class II biosynthetic process, Chagas disease, Allograft rejection Molscript image for 1lk3B00
1.20.1250.10.2.1.1.1.3 2h24A00 Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, negative regulation of cytokine secretion involved in immune response, negative regulation of B cell proliferation, Interleukin-10, receptor biosynthetic process, Autoimmune thyroid disease, leukocyte chemotaxis, Jak-STAT signaling pathway, positive regulation of transcription factor activity, interleukin 10, inflammatory response, type 2 immune response, Leishmaniasis, response to glucocorticoid stimulus, Chagas disease, negative regulation of MHC class II biosynthetic process, Allograft rejection, extracellular space, negative regulation of membrane protein ectodomain proteolysis, positive regulation of cytokine secretion, T cell receptor signaling pathway, Systemic lupus erythematosus, Asthma, positive regulation of gene-specific transcription, Homo sapiens, positive regulation of B cell apoptosis, negative regulation of interleukin-6 production Molscript image for 2h24A00
1.20.1250.10.2.1.1.1.4 1inrA00 positive regulation of cytokine secretion, negative regulation of membrane protein ectodomain proteolysis, extracellular space, Homo sapiens, positive regulation of B cell apoptosis, positive regulation of gene-specific transcription, Asthma, Systemic lupus erythematosus, T cell receptor signaling pathway, negative regulation of interleukin-6 production, negative regulation of B cell proliferation, Intestinal immune network for IgA production, negative regulation of cytokine secretion involved in immune response, Cytokine-cytokine receptor interaction, leukocyte chemotaxis, Autoimmune thyroid disease, receptor biosynthetic process, Interleukin-10, Leishmaniasis, response to glucocorticoid stimulus, type 2 immune response, interleukin 10, inflammatory response, Jak-STAT signaling pathway, positive regulation of transcription factor activity, Allograft rejection, negative regulation of MHC class II biosynthetic process, Chagas disease Molscript image for 1inrA00
1.20.1250.10.2.1.1.1.5 1ilkA00 interleukin 10, inflammatory response, Jak-STAT signaling pathway, positive regulation of transcription factor activity, Leishmaniasis, response to glucocorticoid stimulus, type 2 immune response, negative regulation of MHC class II biosynthetic process, Chagas disease, Allograft rejection, Cytokine-cytokine receptor interaction, negative regulation of B cell proliferation, Intestinal immune network for IgA production, negative regulation of cytokine secretion involved in immune response, receptor biosynthetic process, Interleukin-10, leukocyte chemotaxis, Autoimmune thyroid disease, negative regulation of interleukin-6 production, negative regulation of membrane protein ectodomain proteolysis, extracellular space, positive regulation of cytokine secretion, Asthma, Systemic lupus erythematosus, T cell receptor signaling pathway, Homo sapiens, positive regulation of B cell apoptosis, positive regulation of gene-specific transcription Molscript image for 1ilkA00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.20.1250.10.2.1.1.1