S100 Family: 1.20.1050.10.4.1.1.1

Representative domain: 2c4jA02

Classification Lineage (1.20.1050.10.4.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.20	Up-down Bundle
1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
1.20.1050.10		Gene3D
1.20.1050.10.4
1.20.1050.10.4.1
1.20.1050.10.4.1.1
1.20.1050.10.4.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	27

Non-Redundant Representatives (27)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.20.1050.10.4.1.1.1 (27)

CATH code	Domain ID	Keywords
1.20.1050.10.4.1.1.1.1	2c4jA02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Glutathione S-transferase Mu 2, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.2	2c4jB02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Glutathione S-transferase Mu 2, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.3	2c4jC02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.4	2c4jD02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione S-transferase Mu 2, Homo sapiens
1.20.1050.10.4.1.1.1.5	1xw5A02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Glutathione S-transferase Mu 2, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.6	1xw5B02	glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.7	1hnaA02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Drug metabolism - cytochrome P450, Glutathione metabolism
1.20.1050.10.4.1.1.1.8	1ykcA02	Glutathione S-transferase Mu 2, Homo sapiens, Drug metabolism - cytochrome P450, Glutathione metabolism, glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.9	1ykcB02	glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.10	2ab6A02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione S-transferase Mu 2, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.4.1.1.1.11	2ab6B02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.12	2ab6C02	Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.13	2ab6D02	Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.14	3gurA02	Glutathione S-transferase Mu 2, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.15	3gurB02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity
1.20.1050.10.4.1.1.1.16	3gurC02	glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.17	3gurD02	glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.18	2gtuA02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione S-transferase Mu 2, Homo sapiens, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.19	2gtuB02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity
1.20.1050.10.4.1.1.1.20	3gtuA02	Glutathione metabolism, Drug metabolism - cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.21	3gtuC02	Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.22	1hncA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione S-transferase Mu 2, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.4.1.1.1.23	1hncB02	Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Glutathione S-transferase Mu 2, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.24	1hncC02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione S-transferase Mu 2, Homo sapiens
1.20.1050.10.4.1.1.1.25	1hncD02	glutathione transferase activity, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione S-transferase Mu 2, Drug metabolism - cytochrome P450, Glutathione metabolism, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.4.1.1.1.26	1hnbA02	Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.4.1.1.1.27	1hnbB02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase Mu 2, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione transferase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.20.1050.10.4.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.20.1050.10.4.1.1.1

Classification Lineage (1.20.1050.10.4.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.20.1050.10.4.1.1.1 (27)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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