S100 Family: 1.20.1050.10.1.1.1.1

Representative domain: 1k3yA02

Classification Lineage (1.20.1050.10.1.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.20	Up-down Bundle
1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
1.20.1050.10		Gene3D
1.20.1050.10.1
1.20.1050.10.1.1
1.20.1050.10.1.1.1
1.20.1050.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	34

Non-Redundant Representatives (34)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.20.1050.10.1.1.1.1 (34)

CATH code	Domain ID	Keywords
1.20.1050.10.1.1.1.1.1	1k3yA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Homo sapiens
1.20.1050.10.1.1.1.1.2	1k3yB02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Homo sapiens, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism
1.20.1050.10.1.1.1.1.3	1k3lA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens
1.20.1050.10.1.1.1.1.4	1k3lB02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process
1.20.1050.10.1.1.1.1.5	3ktlA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Homo sapiens, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.1.1.1.1.6	3ktlB02	Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.7	1k3oB02	Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.8	2r3xA02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Homo sapiens, Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.1.1.1.1.9	2r3xB02	Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Homo sapiens, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.10	1xwgA02	Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.11	1xwgB02	Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Homo sapiens, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.12	1ydkA02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.1.1.1.1.13	1ydkB02	glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.14	1gseA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Homo sapiens, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism
1.20.1050.10.1.1.1.1.15	1gseB02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1
1.20.1050.10.1.1.1.1.16	1usbA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.1.1.1.1.17	1usbB02	glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.18	1k3oA02	Homo sapiens, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.19	3l0hA02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Homo sapiens, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism
1.20.1050.10.1.1.1.1.20	3l0hB02	Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.21	1gsdA02	Glutathione transferase., glutathione S-transferase [EC:2.5.1.18], Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Homo sapiens, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450
1.20.1050.10.1.1.1.1.22	1gsdB02	glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.23	1gsdC02	Homo sapiens, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.24	1gsdD02	Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.25	2r6kA02	Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Homo sapiens, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.26	2r6kB02	Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Homo sapiens, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.27	1guhA02	Glutathione metabolism, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Homo sapiens, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.28	1guhB02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, Homo sapiens
1.20.1050.10.1.1.1.1.29	1guhC02	Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Homo sapiens, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.30	1guhD02	Homo sapiens, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.31	1gsfA02	glutathione S-transferase [EC:2.5.1.18], Glutathione transferase., glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Homo sapiens, Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450
1.20.1050.10.1.1.1.1.32	1gsfB02	Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, Homo sapiens, Drug metabolism - cytochrome P450, Glutathione S-transferase A1, Glutathione metabolism, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.
1.20.1050.10.1.1.1.1.33	1gsfC02	Homo sapiens, Glutathione metabolism, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, glutathione metabolic process, Metabolism of xenobiotics by cytochrome P450, Glutathione transferase., glutathione S-transferase [EC:2.5.1.18]
1.20.1050.10.1.1.1.1.34	1gsfD02	Homo sapiens, Glutathione S-transferase A1, Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, glutathione metabolic process, glutathione S-transferase [EC:2.5.1.18], Glutathione transferase.

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.20.1050.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.20.1050.10.1.1.1.1

Classification Lineage (1.20.1050.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.20.1050.10.1.1.1.1 (34)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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