S100 Family: 1.10.8.60.15.1.1.1

Representative domain: 1njgA02

Classification Lineage (1.10.8.60.15.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.8	Helicase, Ruva Protein; domain 3
1.10.8.60		Gene3D
1.10.8.60.15
1.10.8.60.15.1
1.10.8.60.15.1.1
1.10.8.60.15.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	19

Non-Redundant Representatives (19)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.8.60.15.1.1.1 (19)

CATH code	Domain ID	Keywords
1.10.8.60.15.1.1.1.1	1njgA02	DNA polymerase III subunit tau, DNA-dependent DNA replication, DNA replication, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, Mismatch repair, Metabolic pathways, Escherichia coli K-12, protein binding, DNA polymerase III, DnaX complex, Homologous recombination, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], ATPase activity
1.10.8.60.15.1.1.1.2	1njfA02	protein binding, Escherichia coli K-12, Metabolic pathways, ATPase activity, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase III, DnaX complex, Homologous recombination, DNA-dependent DNA replication, DNA replication, DNA polymerase III subunit tau, Mismatch repair, Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase.
1.10.8.60.15.1.1.1.3	1njfB02	Metabolic pathways, Escherichia coli K-12, protein binding, Homologous recombination, DNA polymerase III, DnaX complex, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, ATPase activity, DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, DNA-directed DNA polymerase., Pyrimidine metabolism, Purine metabolism, Mismatch repair
1.10.8.60.15.1.1.1.4	1njfC02	Metabolic pathways, protein binding, Escherichia coli K-12, DNA polymerase III, DnaX complex, Homologous recombination, ATPase activity, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase III subunit tau, DNA-dependent DNA replication, DNA replication, Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase., Mismatch repair
1.10.8.60.15.1.1.1.5	1njfD02	Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., Mismatch repair, DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, Homologous recombination, DNA polymerase III, DnaX complex, ATPase activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, Metabolic pathways, protein binding, Escherichia coli K-12
1.10.8.60.15.1.1.1.6	1jr3A03	DNA replication, DNA-dependent DNA replication, DNA polymerase III subunit tau, Mismatch repair, Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., protein binding, Escherichia coli K-12, Metabolic pathways, ATPase activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, Homologous recombination, DNA polymerase III, DnaX complex
1.10.8.60.15.1.1.1.7	1jr3B03	DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, Mismatch repair, DNA polymerase III subunit tau, DNA-dependent DNA replication, DNA replication, DNA polymerase III, DnaX complex, Homologous recombination, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], ATPase activity, Metabolic pathways, Escherichia coli K-12, protein binding
1.10.8.60.15.1.1.1.8	1jr3C03	DNA polymerase III subunit tau, DNA-dependent DNA replication, DNA replication, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, Mismatch repair, Metabolic pathways, Escherichia coli K-12, protein binding, DNA polymerase III, DnaX complex, Homologous recombination, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], ATPase activity
1.10.8.60.15.1.1.1.9	3glgC02	DNA replication, DNA-dependent DNA replication, DNA polymerase III subunit tau, Mismatch repair, Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., protein binding, Escherichia coli K-12, Metabolic pathways, ATPase activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, Homologous recombination, DNA polymerase III, DnaX complex
1.10.8.60.15.1.1.1.10	3glfB02	DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, DNA-directed DNA polymerase., Pyrimidine metabolism, Purine metabolism, Mismatch repair, Metabolic pathways, Escherichia coli K-12, protein binding, Homologous recombination, DNA polymerase III, DnaX complex, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, ATPase activity
1.10.8.60.15.1.1.1.11	3glfC02	Mismatch repair, Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase., DNA-dependent DNA replication, DNA replication, DNA polymerase III subunit tau, ATPase activity, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase III, DnaX complex, Homologous recombination, protein binding, Escherichia coli K-12, Metabolic pathways
1.10.8.60.15.1.1.1.12	3glfD02	Escherichia coli K-12, protein binding, Metabolic pathways, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], ATPase activity, DNA polymerase III, DnaX complex, Homologous recombination, DNA-dependent DNA replication, DNA replication, DNA polymerase III subunit tau, Mismatch repair, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism
1.10.8.60.15.1.1.1.13	3glfI02	DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., Mismatch repair, Metabolic pathways, protein binding, Escherichia coli K-12, Homologous recombination, DNA polymerase III, DnaX complex, ATPase activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity
1.10.8.60.15.1.1.1.14	1xxhB02	Mismatch repair, DNA-directed DNA polymerase., Pyrimidine metabolism, Purine metabolism, DNA replication, DNA-dependent DNA replication, DNA polymerase III subunit tau, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, ATPase activity, Homologous recombination, DNA polymerase III, DnaX complex, Escherichia coli K-12, protein binding, Metabolic pathways
1.10.8.60.15.1.1.1.15	1xxhC02	Metabolic pathways, protein binding, Escherichia coli K-12, Homologous recombination, DNA polymerase III, DnaX complex, ATPase activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, Pyrimidine metabolism, Purine metabolism, DNA-directed DNA polymerase., Mismatch repair
1.10.8.60.15.1.1.1.16	1xxhD02	DNA polymerase III, DnaX complex, Homologous recombination, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], ATPase activity, Metabolic pathways, Escherichia coli K-12, protein binding, DNA-directed DNA polymerase., Purine metabolism, Pyrimidine metabolism, Mismatch repair, DNA polymerase III subunit tau, DNA-dependent DNA replication, DNA replication
1.10.8.60.15.1.1.1.17	1xxhG02	ATPase activity, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase III, DnaX complex, Homologous recombination, protein binding, Escherichia coli K-12, Metabolic pathways, Mismatch repair, Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase., DNA-dependent DNA replication, DNA replication, DNA polymerase III subunit tau
1.10.8.60.15.1.1.1.18	1xxhH02	ATPase activity, DNA polymerase processivity factor activity, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase III, DnaX complex, Homologous recombination, protein binding, Escherichia coli K-12, Metabolic pathways, Mismatch repair, Purine metabolism, Pyrimidine metabolism, DNA-directed DNA polymerase., DNA-dependent DNA replication, DNA replication, DNA polymerase III subunit tau
1.10.8.60.15.1.1.1.19	1xxhI02	DNA polymerase III subunit tau, DNA replication, DNA-dependent DNA replication, DNA-directed DNA polymerase., Pyrimidine metabolism, Purine metabolism, Mismatch repair, Metabolic pathways, Escherichia coli K-12, protein binding, Homologous recombination, DNA polymerase III, DnaX complex, DNA polymerase III subunit gamma/tau [EC:2.7.7.7], DNA polymerase processivity factor activity, ATPase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.8.60.15.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.8.60.15.1.1.1

Classification Lineage (1.10.8.60.15.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.8.60.15.1.1.1 (19)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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