S100 Family: 1.10.540.10.9.2.1.1

Representative domain: 1egdA01

Classification Lineage (1.10.540.10.9.2.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.540	Butyryl-Coa Dehydrogenase, subunit A; domain 1
1.10.540.10	Butyryl-Coa Dehydrogenase, subunit A, domain 1	Gene3D
1.10.540.10.9
1.10.540.10.9.2
1.10.540.10.9.2.1
1.10.540.10.9.2.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	20

Non-Redundant Representatives (20)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.540.10.9.2.1.1 (20)

CATH code	Domain ID	Keywords
1.10.540.10.9.2.1.1.1	1egdA01	Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, identical protein binding, carnitine metabolic process, CoA-linked, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, medium-chain fatty acid catabolic process, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Acyl-CoA dehydrogenase., Homo sapiens, beta-Alanine metabolism
1.10.540.10.9.2.1.1.2	1egdB01	Homo sapiens, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, identical protein binding, carnitine metabolic process, CoA-linked, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process
1.10.540.10.9.2.1.1.3	1egdC01	Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., Homo sapiens, beta-Alanine metabolism, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, identical protein binding, carnitine metabolic process, CoA-linked, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process
1.10.540.10.9.2.1.1.4	1egdD01	Homo sapiens, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, carnitine metabolic process, CoA-linked, identical protein binding, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism
1.10.540.10.9.2.1.1.5	1egcA01	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine metabolic process, CoA-linked, identical protein binding, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, Homo sapiens, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase.
1.10.540.10.9.2.1.1.6	1egcB01	Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, identical protein binding, carnitine metabolic process, CoA-linked
1.10.540.10.9.2.1.1.7	1egcC01	Homo sapiens, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, carnitine metabolic process, CoA-linked, identical protein binding, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism
1.10.540.10.9.2.1.1.8	1egcD01	Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, medium-chain fatty acid catabolic process, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Fatty acid metabolism, Valine, leucine and isoleucine degradation, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, identical protein binding, carnitine metabolic process, CoA-linked
1.10.540.10.9.2.1.1.9	1egeA01	Acyl-CoA dehydrogenase., Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Homo sapiens, medium-chain fatty acid catabolic process, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, carnitine metabolic process, CoA-linked, identical protein binding, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3]
1.10.540.10.9.2.1.1.10	1egeB01	medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine metabolic process, CoA-linked, identical protein binding
1.10.540.10.9.2.1.1.11	1egeC01	medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, Homo sapiens, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, identical protein binding, carnitine metabolic process, CoA-linked
1.10.540.10.9.2.1.1.12	1egeD01	identical protein binding, carnitine metabolic process, CoA-linked, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, Homo sapiens, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process
1.10.540.10.9.2.1.1.13	2a1tA01	identical protein binding, carnitine metabolic process, CoA-linked, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process
1.10.540.10.9.2.1.1.14	2a1tB01	carnitine metabolic process, CoA-linked, identical protein binding, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Fatty acid metabolism, Valine, leucine and isoleucine degradation, medium-chain fatty acid catabolic process, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity
1.10.540.10.9.2.1.1.15	2a1tC01	acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, identical protein binding, carnitine metabolic process, CoA-linked, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, medium-chain fatty acid catabolic process, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Fatty acid metabolism, Valine, leucine and isoleucine degradation
1.10.540.10.9.2.1.1.16	2a1tD01	beta-Alanine metabolism, Homo sapiens, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, identical protein binding, carnitine metabolic process, CoA-linked, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
1.10.540.10.9.2.1.1.17	1t9gA01	medium-chain fatty acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, Acyl-CoA dehydrogenase., Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, Homo sapiens, carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], carnitine metabolic process, CoA-linked, identical protein binding
1.10.540.10.9.2.1.1.18	1t9gB01	carnitine biosynthetic process, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3], carnitine metabolic process, CoA-linked, identical protein binding, medium-chain fatty acid catabolic process, PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, Acyl-CoA dehydrogenase., Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Homo sapiens
1.10.540.10.9.2.1.1.19	1t9gC01	Valine, leucine and isoleucine degradation, Fatty acid metabolism, Acyl-CoA dehydrogenase., Homo sapiens, beta-Alanine metabolism, fatty acid beta-oxidation using acyl-CoA dehydrogenase, PPAR signaling pathway, oxidation-reduction process, medium-chain fatty acid catabolic process, medium-chain-acyl-CoA dehydrogenase activity, Metabolic pathways, carnitine metabolic process, CoA-linked, identical protein binding, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, Propanoate metabolism, acyl-CoA dehydrogenase [EC:1.3.99.3]
1.10.540.10.9.2.1.1.20	1t9gD01	Homo sapiens, beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Acyl-CoA dehydrogenase., PPAR signaling pathway, oxidation-reduction process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, medium-chain fatty acid catabolic process, Metabolic pathways, medium-chain-acyl-CoA dehydrogenase activity, carnitine metabolic process, CoA-linked, identical protein binding, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, carnitine biosynthetic process, acyl-CoA dehydrogenase [EC:1.3.99.3], Propanoate metabolism

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.540.10.9.2.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.540.10.9.2.1.1

Classification Lineage (1.10.540.10.9.2.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.540.10.9.2.1.1 (20)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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