S100 Family: 1.10.3270.10.1.1.1.1

Representative domain: 2r4fD01

Classification Lineage (1.10.3270.10.1.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.3270	HMGR, N-terminal domain
1.10.3270.10	HMGR, N-terminal domain	Gene3D
1.10.3270.10.1
1.10.3270.10.1.1
1.10.3270.10.1.1.1
1.10.3270.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	81

Non-Redundant Representatives (81)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.3270.10.1.1.1.1 (81)

CATH code	Domain ID	Keywords
1.10.3270.10.1.1.1.1.1	2r4fD01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.2	3cczD01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.3	2r4fA01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.4	3cczA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.5	2r4fB01	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.6	3cczB01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.7	2r4fC01	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.8	3cczC01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.9	1dqaC01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.10	1dqaA01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.11	1dqaB01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.12	2q6bA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.13	2q6bB01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.14	2q6bC01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.15	2q6bD01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.16	2q6cA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.17	2q6cB01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.18	2q6cC01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.19	2q6cD01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.20	1dq8C01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.21	2q1lC01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.22	3cd7C01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.23	1hwlB01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.24	1hwlC01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.25	3cdaD01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.26	3cdaA01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.27	3cdaB01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.28	3cdaC01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.29	2q1lA01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.30	2q1lD01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
1.10.3270.10.1.1.1.1.31	3cd7A01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.32	3cd7D01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.33	2q1lB01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
1.10.3270.10.1.1.1.1.34	3cd7B01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.35	1dq8A01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.36	1dq8B01	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.37	1dq8D01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.38	1hw8B01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.39	1hwlA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.40	3ccwA01	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.41	3ccwB01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.42	3ccwC01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.43	3cctA01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
1.10.3270.10.1.1.1.1.44	3cctB01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
1.10.3270.10.1.1.1.1.45	3cctC01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.46	3ccwD01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.47	3cdbD01	Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis
1.10.3270.10.1.1.1.1.48	3cctD01	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.49	1hwkB01	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.50	1hwjB01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.51	1hwkA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.52	1hwkC01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.53	3bglA01	Homo sapiens, gonad development, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.54	3bglB01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.55	3bglC01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.56	1hwjD01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.57	3cd0D01	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.58	1hwjA01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.59	1hwjC01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.60	1hw9B01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.61	1hwiB01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.62	3cdbA01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.63	3cdbB01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.64	3cdbC01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1.10.3270.10.1.1.1.1.65	1hw9A01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.66	1hwiA01	3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.67	3bglD01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.68	3cd5A01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.69	3cd5B01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.70	3cd5C01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.71	3cd5D01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Homo sapiens, gonad development
1.10.3270.10.1.1.1.1.72	3cd0A01	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.73	3cd0B01	3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.74	3cd0C01	Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, gonad development, Homo sapiens, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34]
1.10.3270.10.1.1.1.1.75	1hwkD01	Homo sapiens, gonad development, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.76	1hw9C01	gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration
1.10.3270.10.1.1.1.1.77	1hw9D01	germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., gonad development, Homo sapiens
1.10.3270.10.1.1.1.1.78	1dq9A01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.79	1dq9B01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], 3-hydroxy-3-methylglutaryl-coenzyme A reductase, germ cell migration, gonad development, Homo sapiens, Hydroxymethylglutaryl-CoA reductase (NADPH)., Metabolic pathways
1.10.3270.10.1.1.1.1.80	1dq9C01	Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH).
1.10.3270.10.1.1.1.1.81	1dq9D01	gonad development, Homo sapiens, Metabolic pathways, Hydroxymethylglutaryl-CoA reductase (NADPH)., Terpenoid backbone biosynthesis, 3-hydroxy-3-methylglutaryl-CoA reductase [EC:1.1.1.34], germ cell migration, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.3270.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.3270.10.1.1.1.1

Classification Lineage (1.10.3270.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.3270.10.1.1.1.1 (81)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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