S100 Family: 1.10.30.10.3.1.1.1

Representative domain: 1gt0D00

Classification Lineage (1.10.30.10.3.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.30	DNA Binding (I), subunit A
1.10.30.10	DNA Binding (I), subunit A	Gene3D
1.10.30.10.3
1.10.30.10.3.1
1.10.30.10.3.1.1
1.10.30.10.3.1.1.1

Summary of Non-Redundant Representatives


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Non-Redundant Representatives (2)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.30.10.3.1.1.1 (2)

CATH Level	CATH code	Domain ID	Keywords	Thumbnail
	1.10.30.10.3.1.1.1.1	1gt0D00	pigment biosynthetic process, positive regulation of neuron differentiation, negative regulation of Wnt receptor signaling pathway, diencephalon morphogenesis, cytoplasm, tongue development, detection of mechanical stimulus involved in sensory perception of sound, positive regulation of Notch signaling pathway, positive regulation of neuroblast proliferation, stem cell maintenance, epithelial tube branching involved in lung morphogenesis, inner ear morphogenesis, negative regulation of transcription from RNA polymerase II promoter, adenohypophysis development, sequence-specific DNA binding, positive regulation of epithelial cell differentiation, negative regulation of osteoblast differentiation, negative regulation of neuron differentiation, protein binding, detection of mechanical stimulus involved in equilibrioception, transcription factor complex, retina morphogenesis in camera-type eye, positive regulation of transcription from RNA polymerase II promoter, male genitalia development, response to retinoic acid, Mus musculus, forebrain neuron differentiation, lens induction in camera-type eye, neuron fate commitment, cerebral cortex development, sequence-specific DNA binding transcription factor activity, olfactory placode formation, Transcription factor SOX-2, lung alveolus development, chromatin binding
	1.10.30.10.3.1.1.1.2	1o4xB00	transcription factor SOX1/2/3/14/21 (SOX group B), negative regulation of epithelial cell proliferation, promoter binding, somatic stem cell maintenance, cytosol, response to wounding, osteoblast differentiation, miRNA binding, protein binding, response to growth factor stimulus, positive regulation of transcription from RNA polymerase II promoter, transcription factor complex, regulation of caspase activity, cell cycle arrest, negative regulation of canonical Wnt receptor signaling pathway, Homo sapiens, Transcription factor SOX-2, positive regulation of MAPKKK cascade, sequence-specific DNA binding transcription factor activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.30.10.3.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.30.10.3.1.1.1

Classification Lineage (1.10.30.10.3.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.30.10.3.1.1.1 (2)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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