S100 Family: 1.10.286.10.1.1.1.1

Representative domain: 1a8rA01

Classification Lineage (1.10.286.10.1.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.286	GTP Cyclohydrolase I; Chain A, domain 1
1.10.286.10		Gene3D
1.10.286.10.1
1.10.286.10.1.1
1.10.286.10.1.1.1
1.10.286.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	105

Non-Redundant Representatives (105)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.286.10.1.1.1.1 (105)

CATH code	Domain ID	Keywords
1.10.286.10.1.1.1.1.1	1a8rA01	GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.2	1a8rB01	GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process
1.10.286.10.1.1.1.1.3	1a8rC01	GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.4	1a8rD01	folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.5	1a8rE01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.6	1a8rF01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.7	1a8rG01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.8	1a8rH01	GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12
1.10.286.10.1.1.1.1.9	1a8rI01	zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.10	1a8rJ01	GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.11	1a8rK01	zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.12	1a8rL01	cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, GTP cyclohydrolase I activity, GTP binding, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.13	1a8rM01	folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.14	1a8rN01	protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.15	1a8rO01	GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12
1.10.286.10.1.1.1.1.16	1n3sA01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.17	1n3sB01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.18	1n3sC01	zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.19	1n3sD01	GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.20	1n3sE01	GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12
1.10.286.10.1.1.1.1.21	1n3sF01	GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process
1.10.286.10.1.1.1.1.22	1n3sG01	GTP binding, GTP cyclohydrolase I activity, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.23	1n3sH01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.24	1n3sI01	queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I., cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.25	1n3sJ01	GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process
1.10.286.10.1.1.1.1.26	1fbxA01	folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.27	1fbxB01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.28	1fbxC01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.29	1fbxD01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.30	1fbxE01	GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.31	1fbxF01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.32	1fbxG01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process
1.10.286.10.1.1.1.1.33	1fbxH01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.34	1fbxI01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.35	1fbxJ01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.36	1fbxK01	GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP binding, GTP cyclohydrolase I activity, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.37	1fbxL01	GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process
1.10.286.10.1.1.1.1.38	1fbxM01	GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process
1.10.286.10.1.1.1.1.39	1fbxN01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.40	1fbxO01	GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding
1.10.286.10.1.1.1.1.41	1n3rA01	protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.42	1n3rB01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.43	1n3rC01	GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding
1.10.286.10.1.1.1.1.44	1n3rD01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.45	1n3rE01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.46	1n3rF01	Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.47	1n3rG01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.48	1n3rH01	GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.49	1n3rI01	folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, GTP binding, GTP cyclohydrolase I activity, cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.50	1n3rJ01	GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding
1.10.286.10.1.1.1.1.51	1n3rK01	GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding
1.10.286.10.1.1.1.1.52	1n3rL01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.53	1n3rM01	GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.54	1n3rN01	cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.55	1n3rO01	queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I., cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.56	1a9cA01	protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.57	1a9cB01	cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP binding, GTP cyclohydrolase I activity, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.58	1a9cC01	cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.59	1a9cD01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.60	1a9cE01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.61	1a9cF01	queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I., cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.62	1a9cG01	GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.63	1a9cH01	GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.64	1a9cI01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.65	1a9cJ01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.66	1a9cK01	GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12
1.10.286.10.1.1.1.1.67	1a9cL01	queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I., cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.68	1a9cM01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.69	1a9cN01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.70	1a9cO01	Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.71	1gtpA01	folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP binding, GTP cyclohydrolase I activity, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.72	1gtpB01	folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis, GTP binding, GTP cyclohydrolase I activity, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.73	1gtpC01	GTP cyclohydrolase I activity, GTP binding, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.74	1gtpD01	cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, GTP binding, GTP cyclohydrolase I activity, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.75	1gtpE01	GTP binding, GTP cyclohydrolase I activity, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways
1.10.286.10.1.1.1.1.76	1gtpF01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.77	1gtpG01	GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process
1.10.286.10.1.1.1.1.78	1gtpH01	protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.79	1gtpI01	GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12
1.10.286.10.1.1.1.1.80	1gtpJ01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.81	1gtpK01	Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.82	1gtpL01	Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.83	1gtpM01	protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.84	1gtpN01	protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.85	1gtpO01	GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP cyclohydrolase I., folic acid biosynthetic process, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16]
1.10.286.10.1.1.1.1.86	1gtpP01	zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I.
1.10.286.10.1.1.1.1.87	1gtpQ01	Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.88	1gtpR01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process, GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.89	1gtpS01	GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP binding, GTP cyclohydrolase I activity, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.90	1gtpT01	GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.91	1n3tA01	folic acid biosynthetic process, GTP cyclohydrolase I., Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex
1.10.286.10.1.1.1.1.92	1n3tB01	Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, GTP cyclohydrolase 1, protein complex, GTP binding, GTP cyclohydrolase I activity
1.10.286.10.1.1.1.1.93	1n3tC01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.94	1n3tD01	folic acid biosynthetic process, GTP cyclohydrolase I., GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I activity, GTP binding, zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.95	1n3tE01	protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.96	1n3tF01	protein complex, GTP cyclohydrolase 1, zinc ion binding, cytoplasm, GTP cyclohydrolase I activity, GTP binding, Folate biosynthesis, Escherichia coli K-12, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.97	1n3tG01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.98	1n3tH01	folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, Escherichia coli K-12, Folate biosynthesis, GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, protein complex, GTP cyclohydrolase 1
1.10.286.10.1.1.1.1.99	1n3tI01	Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, GTP cyclohydrolase I., folic acid biosynthetic process, protein complex, GTP cyclohydrolase 1, cytoplasm, zinc ion binding, GTP cyclohydrolase I activity, GTP binding
1.10.286.10.1.1.1.1.100	1n3tJ01	GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm, GTP binding, GTP cyclohydrolase I activity, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.101	1n3tK01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP binding, GTP cyclohydrolase I activity, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.102	1n3tL01	GTP cyclohydrolase I activity, GTP binding, cytoplasm, zinc ion binding, GTP cyclohydrolase 1, protein complex, folic acid biosynthetic process, GTP cyclohydrolase I., queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], Escherichia coli K-12, Folate biosynthesis
1.10.286.10.1.1.1.1.103	1n3tM01	GTP cyclohydrolase I., folic acid biosynthetic process, Folate biosynthesis, Escherichia coli K-12, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], queuosine biosynthetic process, GTP cyclohydrolase I activity, GTP binding, GTP cyclohydrolase 1, protein complex, zinc ion binding, cytoplasm
1.10.286.10.1.1.1.1.104	1n3tN01	GTP cyclohydrolase 1, protein complex, cytoplasm, zinc ion binding, GTP binding, GTP cyclohydrolase I activity, Escherichia coli K-12, Folate biosynthesis, queuosine biosynthetic process, Metabolic pathways, GTP cyclohydrolase I [EC:3.5.4.16], GTP cyclohydrolase I., folic acid biosynthetic process
1.10.286.10.1.1.1.1.105	1n3tO01	GTP cyclohydrolase I [EC:3.5.4.16], Metabolic pathways, queuosine biosynthetic process, Folate biosynthesis, Escherichia coli K-12, folic acid biosynthetic process, GTP cyclohydrolase I., zinc ion binding, cytoplasm, protein complex, GTP cyclohydrolase 1, GTP binding, GTP cyclohydrolase I activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.286.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.286.10.1.1.1.1

Classification Lineage (1.10.286.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.286.10.1.1.1.1 (105)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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