S100 Family: 1.10.238.10.7.1.1.1

Representative domain: 3c1vA00

Classification Lineage (1.10.238.10.7.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.238	Recoverin; domain 1
1.10.238.10	EF-hand	Gene3D
1.10.238.10.7
1.10.238.10.7.1
1.10.238.10.7.1.1
1.10.238.10.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	30

Non-Redundant Representatives (30)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.238.10.7.1.1.1 (30)

CATH code	Domain ID	Keywords
1.10.238.10.7.1.1.1.1	3c1vA00	epithelial to mesenchymal transition, Homo sapiens, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade
1.10.238.10.7.1.1.1.2	3c1vC00	epithelial to mesenchymal transition, Homo sapiens, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade
1.10.238.10.7.1.1.1.3	3c1vB00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.4	3c1vD00	nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.5	2q91A00	calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, Homo sapiens, epithelial to mesenchymal transition
1.10.238.10.7.1.1.1.6	2q91B00	Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, Homo sapiens, epithelial to mesenchymal transition
1.10.238.10.7.1.1.1.7	3cgaA00	Homo sapiens, epithelial to mesenchymal transition, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus
1.10.238.10.7.1.1.1.8	3cgaB00	positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, Homo sapiens, epithelial to mesenchymal transition
1.10.238.10.7.1.1.1.9	3ko0A00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.10	3ko0B00	Homo sapiens, epithelial to mesenchymal transition, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.11	3ko0C00	nucleus, Protein S100-A4, RAGE receptor binding, calcium ion binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.12	3ko0D00	nucleus, Protein S100-A4, RAGE receptor binding, calcium ion binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.13	3ko0I00	epithelial to mesenchymal transition, Homo sapiens, nucleus, Protein S100-A4, RAGE receptor binding, calcium ion binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade
1.10.238.10.7.1.1.1.14	3ko0J00	Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, Homo sapiens, epithelial to mesenchymal transition
1.10.238.10.7.1.1.1.15	3ko0K00	positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, Homo sapiens, epithelial to mesenchymal transition
1.10.238.10.7.1.1.1.16	3ko0L00	Homo sapiens, epithelial to mesenchymal transition, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus
1.10.238.10.7.1.1.1.17	3ko0O00	epithelial to mesenchymal transition, Homo sapiens, nucleus, Protein S100-A4, RAGE receptor binding, calcium ion binding, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade
1.10.238.10.7.1.1.1.18	3ko0R00	epithelial to mesenchymal transition, Homo sapiens, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, Protein S100-A4, RAGE receptor binding, calcium ion binding
1.10.238.10.7.1.1.1.19	3ko0S00	Homo sapiens, epithelial to mesenchymal transition, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.20	3ko0T00	Homo sapiens, epithelial to mesenchymal transition, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.21	3ko0H00	Homo sapiens, epithelial to mesenchymal transition, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.22	3ko0E00	Homo sapiens, epithelial to mesenchymal transition, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.23	3ko0M00	Homo sapiens, epithelial to mesenchymal transition, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.24	3ko0N00	epithelial to mesenchymal transition, Homo sapiens, perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding
1.10.238.10.7.1.1.1.25	3ko0P00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.26	3ko0F00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.27	3ko0G00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens
1.10.238.10.7.1.1.1.28	3ko0Q00	Homo sapiens, epithelial to mesenchymal transition, Protein S100-A4, RAGE receptor binding, calcium ion binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.29	1m31A00	Homo sapiens, epithelial to mesenchymal transition, calcium ion binding, Protein S100-A4, RAGE receptor binding, nucleus, positive regulation of I-kappaB kinase/NF-kappaB cascade, perinuclear region of cytoplasm
1.10.238.10.7.1.1.1.30	1m31B00	perinuclear region of cytoplasm, positive regulation of I-kappaB kinase/NF-kappaB cascade, nucleus, calcium ion binding, Protein S100-A4, RAGE receptor binding, epithelial to mesenchymal transition, Homo sapiens

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.238.10.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.238.10.7.1.1.1

Classification Lineage (1.10.238.10.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.238.10.7.1.1.1 (30)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts