S100 Family: 1.10.238.10.18.1.1.1

Representative domain: 1g4yR01

Classification Lineage (1.10.238.10.18.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.238	Recoverin; domain 1
1.10.238.10	EF-hand	Gene3D
1.10.238.10.18
1.10.238.10.18.1
1.10.238.10.18.1.1
1.10.238.10.18.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	36

Non-Redundant Representatives (36)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.238.10.18.1.1.1 (36)

CATH code	Domain ID	Keywords
1.10.238.10.18.1.1.1.1	1g4yR01	GnRH signaling pathway, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Olfactory transduction, calmodulin, Phosphatidylinositol signaling system, Rattus norvegicus, Oocyte meiosis, Melanogenesis, Neurotrophin signaling pathway, Long-term potentiation, Insulin signaling pathway, Glioma
1.10.238.10.18.1.1.1.2	2f3yA01	Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, GnRH signaling pathway, regulation of cytokinesis, plasma membrane, centrosome, spindle pole, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, calcium ion binding, calmodulin, Olfactory transduction, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, Homo sapiens, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, titin binding, Long-term potentiation
1.10.238.10.18.1.1.1.3	2f3zA01	Insulin signaling pathway, titin binding, Long-term potentiation, N-terminal myristoylation domain binding, Glioma, Oocyte meiosis, Melanogenesis, Homo sapiens, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, calcium ion binding, calmodulin, Olfactory transduction, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, centrosome, spindle pole, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Vascular smooth muscle contraction
1.10.238.10.18.1.1.1.4	1cllA01	Vascular smooth muscle contraction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, centrosome, spindle pole, regulation of cytokinesis, plasma membrane, GnRH signaling pathway, spindle microtubule, Phosphatidylinositol signaling system, response to calcium ion, Olfactory transduction, calmodulin, calcium ion binding, Neurotrophin signaling pathway, protein domain specific binding, G-protein coupled receptor protein signaling pathway, Homo sapiens, Oocyte meiosis, Melanogenesis, Glioma, N-terminal myristoylation domain binding, Long-term potentiation, titin binding, Insulin signaling pathway
1.10.238.10.18.1.1.1.5	1mxeA01	regulation of light-activated channel activity, myosin VI head/neck binding, rhabdomere, kinetochore organization, myosin VI complex, centriole replication, Drosophila melanogaster, Calmodulin, adaptation of rhodopsin mediated signaling, protein phosphorylation, spindle pole, Phosphatidylinositol signaling system, positive regulation of NFAT protein import into nucleus, calmodulin, cytoplasm, metarhodopsin inactivation, mitotic spindle organization
1.10.238.10.18.1.1.1.6	1mxeB01	adaptation of rhodopsin mediated signaling, Calmodulin, spindle pole, protein phosphorylation, Phosphatidylinositol signaling system, positive regulation of NFAT protein import into nucleus, calmodulin, metarhodopsin inactivation, cytoplasm, mitotic spindle organization, rhabdomere, myosin VI head/neck binding, regulation of light-activated channel activity, kinetochore organization, centriole replication, myosin VI complex, Drosophila melanogaster
1.10.238.10.18.1.1.1.7	1up5B01	Glioma, N-terminal myristoylation domain binding, titin binding, Long-term potentiation, Insulin signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, G-protein coupled receptor protein signaling pathway, Homo sapiens, Oocyte meiosis, Melanogenesis, Phosphatidylinositol signaling system, spindle microtubule, response to calcium ion, Olfactory transduction, calcium ion binding, calmodulin, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, spindle pole, centrosome, GnRH signaling pathway, plasma membrane, regulation of cytokinesis
1.10.238.10.18.1.1.1.8	1up5A01	Olfactory transduction, calmodulin, calcium ion binding, spindle microtubule, Phosphatidylinositol signaling system, response to calcium ion, spindle pole, centrosome, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, Vascular smooth muscle contraction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Long-term potentiation, titin binding, Insulin signaling pathway, Glioma, N-terminal myristoylation domain binding, Homo sapiens, Oocyte meiosis, Melanogenesis, Neurotrophin signaling pathway, protein domain specific binding, G-protein coupled receptor protein signaling pathway
1.10.238.10.18.1.1.1.9	1cdlA01	Melanogenesis, Oocyte meiosis, Homo sapiens, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Insulin signaling pathway, Long-term potentiation, titin binding, N-terminal myristoylation domain binding, Glioma, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, centrosome, spindle pole, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Vascular smooth muscle contraction, calmodulin, calcium ion binding, Olfactory transduction, response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system
1.10.238.10.18.1.1.1.10	1cdlD01	response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Vascular smooth muscle contraction, regulation of cytokinesis, plasma membrane, GnRH signaling pathway, centrosome, spindle pole, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Oocyte meiosis, Melanogenesis, Homo sapiens
1.10.238.10.18.1.1.1.11	2be6B01	G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, Homo sapiens, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, titin binding, Long-term potentiation, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Vascular smooth muscle contraction, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, centrosome, spindle pole, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, calcium ion binding, calmodulin, Olfactory transduction
1.10.238.10.18.1.1.1.12	4clnA01	rhabdomere, myosin VI head/neck binding, regulation of light-activated channel activity, kinetochore organization, centriole replication, myosin VI complex, Drosophila melanogaster, adaptation of rhodopsin mediated signaling, Calmodulin, spindle pole, protein phosphorylation, Phosphatidylinositol signaling system, positive regulation of NFAT protein import into nucleus, mitotic spindle organization, calmodulin, cytoplasm, metarhodopsin inactivation
1.10.238.10.18.1.1.1.13	2be6C01	Olfactory transduction, calcium ion binding, calmodulin, Phosphatidylinositol signaling system, spindle microtubule, response to calcium ion, spindle pole, centrosome, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, titin binding, Long-term potentiation, Insulin signaling pathway, Glioma, N-terminal myristoylation domain binding, Homo sapiens, Melanogenesis, Oocyte meiosis, protein domain specific binding, Neurotrophin signaling pathway, G-protein coupled receptor protein signaling pathway
1.10.238.10.18.1.1.1.14	3clnA01	Melanogenesis, Oocyte meiosis, Neurotrophin signaling pathway, Long-term potentiation, Insulin signaling pathway, Glioma, GnRH signaling pathway, Vascular smooth muscle contraction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Olfactory transduction, calmodulin, Phosphatidylinositol signaling system, Rattus norvegicus
1.10.238.10.18.1.1.1.15	1l7zA01	Melanogenesis, Oocyte meiosis, Homo sapiens, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Insulin signaling pathway, titin binding, Long-term potentiation, N-terminal myristoylation domain binding, Glioma, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, spindle pole, centrosome, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Vascular smooth muscle contraction, calcium ion binding, calmodulin, Olfactory transduction, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule
1.10.238.10.18.1.1.1.16	1qiwA01	Vascular smooth muscle contraction, Calmodulin, Alzheimer's disease, Calcium signaling pathway, centrosome, spindle pole, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, Phosphatidylinositol signaling system, spindle microtubule, response to calcium ion, Olfactory transduction, calcium ion binding, calmodulin, protein domain specific binding, Neurotrophin signaling pathway, G-protein coupled receptor protein signaling pathway, Homo sapiens, Melanogenesis, Oocyte meiosis, Glioma, N-terminal myristoylation domain binding, titin binding, Long-term potentiation, Insulin signaling pathway
1.10.238.10.18.1.1.1.17	1qiwB01	calcium ion binding, calmodulin, Olfactory transduction, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, GnRH signaling pathway, regulation of cytokinesis, plasma membrane, spindle pole, centrosome, Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, Insulin signaling pathway, titin binding, Long-term potentiation, N-terminal myristoylation domain binding, Glioma, Melanogenesis, Oocyte meiosis, Homo sapiens, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway
1.10.238.10.18.1.1.1.18	1qx5K01	Olfactory transduction, calmodulin, Phosphatidylinositol signaling system, Rattus norvegicus, GnRH signaling pathway, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Long-term potentiation, Insulin signaling pathway, Glioma, Oocyte meiosis, Melanogenesis, Neurotrophin signaling pathway
1.10.238.10.18.1.1.1.19	2bkhB01	Phosphatidylinositol signaling system, positive regulation of NFAT protein import into nucleus, mitotic spindle organization, calmodulin, cytoplasm, metarhodopsin inactivation, adaptation of rhodopsin mediated signaling, Calmodulin, spindle pole, protein phosphorylation, centriole replication, myosin VI complex, Drosophila melanogaster, rhabdomere, myosin VI head/neck binding, regulation of light-activated channel activity, kinetochore organization
1.10.238.10.18.1.1.1.20	1qivA01	Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, GnRH signaling pathway, regulation of cytokinesis, plasma membrane, spindle pole, centrosome, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, calcium ion binding, calmodulin, Olfactory transduction, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, Homo sapiens, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, titin binding, Long-term potentiation
1.10.238.10.18.1.1.1.21	1k90D01	G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Melanogenesis, Oocyte meiosis, Homo sapiens, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Vascular smooth muscle contraction, regulation of cytokinesis, plasma membrane, GnRH signaling pathway, centrosome, spindle pole, response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction
1.10.238.10.18.1.1.1.22	1k90F01	response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Vascular smooth muscle contraction, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, spindle pole, centrosome, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Oocyte meiosis, Melanogenesis, Homo sapiens
1.10.238.10.18.1.1.1.23	1k93D01	N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Oocyte meiosis, Melanogenesis, Homo sapiens, response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Vascular smooth muscle contraction, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, spindle pole, centrosome
1.10.238.10.18.1.1.1.24	1k93E01	response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, calcium ion binding, calmodulin, Olfactory transduction, Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, spindle pole, centrosome, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, titin binding, Long-term potentiation, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, Homo sapiens
1.10.238.10.18.1.1.1.25	1k93F01	Olfactory transduction, calmodulin, calcium ion binding, spindle microtubule, Phosphatidylinositol signaling system, response to calcium ion, spindle pole, centrosome, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, Vascular smooth muscle contraction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Long-term potentiation, titin binding, Insulin signaling pathway, Glioma, N-terminal myristoylation domain binding, Homo sapiens, Oocyte meiosis, Melanogenesis, Neurotrophin signaling pathway, protein domain specific binding, G-protein coupled receptor protein signaling pathway
1.10.238.10.18.1.1.1.26	1sk6D01	response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Vascular smooth muscle contraction, plasma membrane, regulation of cytokinesis, GnRH signaling pathway, centrosome, spindle pole, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Melanogenesis, Oocyte meiosis, Homo sapiens
1.10.238.10.18.1.1.1.27	1sk6E01	response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, calcium ion binding, calmodulin, Olfactory transduction, Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, GnRH signaling pathway, regulation of cytokinesis, plasma membrane, centrosome, spindle pole, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, titin binding, Long-term potentiation, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, Homo sapiens
1.10.238.10.18.1.1.1.28	1sk6F01	GnRH signaling pathway, plasma membrane, regulation of cytokinesis, spindle pole, centrosome, Calmodulin, Alzheimer's disease, Calcium signaling pathway, Vascular smooth muscle contraction, calcium ion binding, calmodulin, Olfactory transduction, response to calcium ion, Phosphatidylinositol signaling system, spindle microtubule, Oocyte meiosis, Melanogenesis, Homo sapiens, G-protein coupled receptor protein signaling pathway, protein domain specific binding, Neurotrophin signaling pathway, Insulin signaling pathway, titin binding, Long-term potentiation, N-terminal myristoylation domain binding, Glioma
1.10.238.10.18.1.1.1.29	1pk0D01	response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Vascular smooth muscle contraction, regulation of cytokinesis, plasma membrane, GnRH signaling pathway, centrosome, spindle pole, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Melanogenesis, Oocyte meiosis, Homo sapiens
1.10.238.10.18.1.1.1.30	1pk0E01	spindle pole, centrosome, GnRH signaling pathway, plasma membrane, regulation of cytokinesis, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Olfactory transduction, calcium ion binding, calmodulin, Phosphatidylinositol signaling system, spindle microtubule, response to calcium ion, Homo sapiens, Melanogenesis, Oocyte meiosis, protein domain specific binding, Neurotrophin signaling pathway, G-protein coupled receptor protein signaling pathway, titin binding, Long-term potentiation, Insulin signaling pathway, Glioma, N-terminal myristoylation domain binding
1.10.238.10.18.1.1.1.31	1pk0F01	response to calcium ion, spindle microtubule, Phosphatidylinositol signaling system, calmodulin, calcium ion binding, Olfactory transduction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Vascular smooth muscle contraction, regulation of cytokinesis, plasma membrane, GnRH signaling pathway, spindle pole, centrosome, N-terminal myristoylation domain binding, Glioma, Insulin signaling pathway, Long-term potentiation, titin binding, G-protein coupled receptor protein signaling pathway, Neurotrophin signaling pathway, protein domain specific binding, Oocyte meiosis, Melanogenesis, Homo sapiens
1.10.238.10.18.1.1.1.32	1x02A01	Calmodulin, Calcium signaling pathway, Alzheimer's disease, Vascular smooth muscle contraction, GnRH signaling pathway, Phosphatidylinositol signaling system, calmodulin, Olfactory transduction, Neurotrophin signaling pathway, Oocyte meiosis, Melanogenesis, receptor binding, Glioma, Xenopus laevis, Insulin signaling pathway, Long-term potentiation
1.10.238.10.18.1.1.1.33	1cffA01	Olfactory transduction, calmodulin, Phosphatidylinositol signaling system, GnRH signaling pathway, Vascular smooth muscle contraction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Long-term potentiation, Insulin signaling pathway, Xenopus laevis, Glioma, receptor binding, Melanogenesis, Oocyte meiosis, Neurotrophin signaling pathway
1.10.238.10.18.1.1.1.34	1ckkA01	GnRH signaling pathway, Vascular smooth muscle contraction, Calmodulin, Calcium signaling pathway, Alzheimer's disease, Olfactory transduction, calmodulin, Phosphatidylinositol signaling system, receptor binding, Melanogenesis, Oocyte meiosis, Neurotrophin signaling pathway, Long-term potentiation, Insulin signaling pathway, Glioma, Xenopus laevis
1.10.238.10.18.1.1.1.35	1muxA01	receptor binding, Melanogenesis, Oocyte meiosis, Neurotrophin signaling pathway, Long-term potentiation, Insulin signaling pathway, Xenopus laevis, Glioma, GnRH signaling pathway, Vascular smooth muscle contraction, Calcium signaling pathway, Alzheimer's disease, Calmodulin, Olfactory transduction, calmodulin, Phosphatidylinositol signaling system
1.10.238.10.18.1.1.1.36	1nwdA01	Insulin signaling pathway, Long-term potentiation, Xenopus laevis, Glioma, Oocyte meiosis, Melanogenesis, receptor binding, Neurotrophin signaling pathway, calmodulin, Olfactory transduction, Phosphatidylinositol signaling system, GnRH signaling pathway, Alzheimer's disease, Calcium signaling pathway, Calmodulin, Vascular smooth muscle contraction

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.238.10.18.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.238.10.18.1.1.1

Classification Lineage (1.10.238.10.18.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.238.10.18.1.1.1 (36)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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