S100 Family: 1.10.1670.10.7.1.1.1

Representative domain: 1mpgA03

Classification Lineage (1.10.1670.10.7.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.1670	Endonuclease Iii, domain 2
1.10.1670.10	Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)	Gene3D
1.10.1670.10.7
1.10.1670.10.7.1
1.10.1670.10.7.1.1
1.10.1670.10.7.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	38

Non-Redundant Representatives (38)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.1670.10.7.1.1.1 (38)

CATH code	Domain ID	Keywords
1.10.1670.10.7.1.1.1.1	1mpgA03	alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.2	1mpgB03	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.1670.10.7.1.1.1.3	3cw7A03	DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.1670.10.7.1.1.1.4	3cw7B03	DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair
1.10.1670.10.7.1.1.1.5	3cw7C03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.1670.10.7.1.1.1.6	3cw7D03	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.1670.10.7.1.1.1.7	3cwsA03	alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.8	3cwsB03	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.1670.10.7.1.1.1.9	3cwtA03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12
1.10.1670.10.7.1.1.1.10	3cwtC03	alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.11	3cwsC03	DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.1670.10.7.1.1.1.12	3cwsD03	DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, base-excision repair
1.10.1670.10.7.1.1.1.13	3cwtB03	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.14	3cwtD03	Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair
1.10.1670.10.7.1.1.1.15	1pvsA03	base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding
1.10.1670.10.7.1.1.1.16	1pvsB03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12
1.10.1670.10.7.1.1.1.17	3cvsA03	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.18	3cvsB03	Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.1670.10.7.1.1.1.19	3cvsC03	base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II.
1.10.1670.10.7.1.1.1.20	3cvsD03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12
1.10.1670.10.7.1.1.1.21	3cwaA03	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.1670.10.7.1.1.1.22	3cwaB03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12
1.10.1670.10.7.1.1.1.23	3cwaC03	DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.1670.10.7.1.1.1.24	3cwaD03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.1670.10.7.1.1.1.25	1dizA03	DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.1670.10.7.1.1.1.26	1dizB03	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.27	3cvtA03	base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding
1.10.1670.10.7.1.1.1.28	3cvtB03	base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding
1.10.1670.10.7.1.1.1.29	3cvtC03	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.1670.10.7.1.1.1.30	3cvtD03	Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.1670.10.7.1.1.1.31	3cwuA03	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.32	3cwuB03	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.1670.10.7.1.1.1.33	3cwuC03	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.34	3cwuD03	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.1670.10.7.1.1.1.35	3d4vA03	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.1670.10.7.1.1.1.36	3d4vB03	DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.1670.10.7.1.1.1.37	3d4vC03	alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2
1.10.1670.10.7.1.1.1.38	3d4vD03	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.1670.10.7.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.1670.10.7.1.1.1

Classification Lineage (1.10.1670.10.7.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.1670.10.7.1.1.1 (38)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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