S100 Family: 1.10.150.20.13.1.1.1

Representative domain: 2bcqA02

Classification Lineage (1.10.150.20.13.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.150	DNA polymerase; domain 1
1.10.150.20	5' to 3' exonuclease, C-terminal subdomain	Gene3D
1.10.150.20.13
1.10.150.20.13.1
1.10.150.20.13.1.1
1.10.150.20.13.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	33

Non-Redundant Representatives (33)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.150.20.13.1.1.1 (33)

CATH code	Domain ID	Keywords
1.10.150.20.13.1.1.1.1	2bcqA02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda, Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair
1.10.150.20.13.1.1.1.2	2bcrA02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Non-homologous end-joining, Base excision repair, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.3	2pfnA02	DNA-directed DNA polymerase., DNA polymerase lambda, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], Homo sapiens, nucleotide-excision repair, Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining
1.10.150.20.13.1.1.1.4	1xsnA02	Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.5	3hw8A02	Homo sapiens, nucleotide-excision repair, Other carbon-oxygen lyases., Non-homologous end-joining, Base excision repair, DNA-directed DNA polymerase., DNA polymerase lambda, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-]
1.10.150.20.13.1.1.1.6	3hwtA02	Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.7	2bcvA02	nucleotide-excision repair, Homo sapiens, Non-homologous end-joining, Base excision repair, Other carbon-oxygen lyases., DNA polymerase lambda, DNA-directed DNA polymerase., DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-]
1.10.150.20.13.1.1.1.8	2pfoA02	Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.9	1rztA02	Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.10	1rztE02	Homo sapiens, nucleotide-excision repair, Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, DNA-directed DNA polymerase., DNA polymerase lambda, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-]
1.10.150.20.13.1.1.1.11	1rztI02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.12	1rztM02	Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.13	2pfpA02	Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.14	2pfqA02
1.10.150.20.13.1.1.1.15	1xspA02	Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.16	2bcsA02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.17	2bcuA02	DNA-directed DNA polymerase., DNA polymerase lambda, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], Homo sapiens, nucleotide-excision repair, Other carbon-oxygen lyases., Non-homologous end-joining, Base excision repair
1.10.150.20.13.1.1.1.18	3c5gA02	Other carbon-oxygen lyases., Non-homologous end-joining, Base excision repair, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.19	3c5gB02	Other carbon-oxygen lyases., Non-homologous end-joining, Base excision repair, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.20	3c5fA02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.21	3c5fB02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda, Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair
1.10.150.20.13.1.1.1.22	1xslA02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.23	1xslE02	Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.24	1xslI02	Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.25	1xslM02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.26	2gwsA02	Non-homologous end-joining, Base excision repair, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.27	2gwsE02	Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda
1.10.150.20.13.1.1.1.28	2gwsI02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Non-homologous end-joining, Base excision repair, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.29	2gwsM02	Non-homologous end-joining, Base excision repair, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase.
1.10.150.20.13.1.1.1.30	3hx0A02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA-directed DNA polymerase., DNA polymerase lambda, Other carbon-oxygen lyases., Base excision repair, Non-homologous end-joining, Homo sapiens, nucleotide-excision repair
1.10.150.20.13.1.1.1.31	3hx0F02	Homo sapiens, nucleotide-excision repair, Other carbon-oxygen lyases., Non-homologous end-joining, Base excision repair, DNA-directed DNA polymerase., DNA polymerase lambda, DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-]
1.10.150.20.13.1.1.1.32	3hx0K02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens
1.10.150.20.13.1.1.1.33	3hx0P02	DNA polymerase lambda subunit [EC:2.7.7.7 4.2.99.-], DNA polymerase lambda, DNA-directed DNA polymerase., Base excision repair, Non-homologous end-joining, Other carbon-oxygen lyases., nucleotide-excision repair, Homo sapiens

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.150.20.13.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.150.20.13.1.1.1

Classification Lineage (1.10.150.20.13.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.150.20.13.1.1.1 (33)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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