×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 1.10.10.1500

JmjC domain-containing ribosomal oxygenase (ROX), dimer domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
JmjC domain-containing ribosomal oxygenase (ROX), dimer domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: JmjC domain-containing ribosomal oxygenase (ROX), dimer domain

According to scientific literature, the JmjC domain-containing proteins belong to a large family of oxygenases possessing distinct substrate specificities which are involved in the regulation of different biological processes, such as gene transcription, RNA processing and translation.

Key roles: histone lysine demethylase and ribosomal histidine hydroxylase activity

Representative proteins: MYC-induced nuclear antigen (Mina53), bifunctional lysine-specific demethylase and histidyl-hydroxylase Nucleolar protein 66 (NO66) - catalyse histidine hydroxylation in humans

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
417 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 32
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 13
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC: 1
Unique GO: 24
Taxonomy
Unique Species: 417
CATH-Gene3D is a Global Biodata Core Resource Learn more...