S100 Family: 1.10.10.10.65.1.1.1

Representative domain: 1hw5A02

Classification Lineage (1.10.10.10.65.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.10	Arc Repressor Mutant, subunit A
1.10.10.10	"winged helix" repressor DNA binding domain	Gene3D
1.10.10.10.65
1.10.10.10.65.1
1.10.10.10.65.1.1
1.10.10.10.65.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	42

Non-Redundant Representatives (42)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.10.10.65.1.1.1 (42)

CATH code	Domain ID	Keywords
1.10.10.10.65.1.1.1.1	1hw5A02	Escherichia coli K-12, transcription, protein binding, transcription repressor activity, transcription activator activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.2	1hw5B02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli K-12, transcription, protein binding, transcription repressor activity, transcription activator activity, Catabolite gene activator
1.10.10.10.65.1.1.1.3	1i5zA02	transcription activator activity, transcription repressor activity, Catabolite gene activator, Escherichia coli K-12, protein binding, transcription, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.4	1i5zB02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Catabolite gene activator, transcription activator activity, transcription repressor activity, protein binding, transcription, Escherichia coli K-12
1.10.10.10.65.1.1.1.5	1zrfA02	transcription, protein binding, Escherichia coli K-12, Catabolite gene activator, transcription activator activity, transcription repressor activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.6	1zrfB02	protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription activator activity, transcription repressor activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.7	1g6nA02	transcription activator activity, transcription repressor activity, Catabolite gene activator, Escherichia coli K-12, protein binding, transcription, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.8	1g6nB02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli K-12, transcription, protein binding, transcription repressor activity, transcription activator activity, Catabolite gene activator
1.10.10.10.65.1.1.1.9	2gzwD02	Escherichia coli K-12, protein binding, transcription, transcription activator activity, transcription repressor activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.10	1i6xA02	Escherichia coli K-12, protein binding, transcription, transcription activator activity, transcription repressor activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.11	1i6xB02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity
1.10.10.10.65.1.1.1.12	2cgpA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Catabolite gene activator, transcription activator activity, transcription repressor activity, protein binding, transcription, Escherichia coli K-12
1.10.10.10.65.1.1.1.13	2gzwA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity
1.10.10.10.65.1.1.1.14	2gzwC02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, transcription repressor activity, transcription activator activity, Catabolite gene activator, Escherichia coli K-12, transcription, protein binding
1.10.10.10.65.1.1.1.15	2gzwB02	transcription activator activity, transcription repressor activity, Catabolite gene activator, Escherichia coli K-12, protein binding, transcription, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.16	1j59A02	protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.17	1j59B02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli K-12, transcription, protein binding, transcription activator activity, transcription repressor activity, Catabolite gene activator
1.10.10.10.65.1.1.1.18	1runA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli K-12, protein binding, transcription, transcription activator activity, transcription repressor activity, Catabolite gene activator
1.10.10.10.65.1.1.1.19	1runB02	transcription, protein binding, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.20	1zrcA02	Escherichia coli K-12, transcription, protein binding, transcription repressor activity, transcription activator activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.21	1zrcB02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, transcription repressor activity, transcription activator activity, Catabolite gene activator, Escherichia coli K-12, transcription, protein binding
1.10.10.10.65.1.1.1.22	1zrdA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, transcription repressor activity, transcription activator activity, Catabolite gene activator, Escherichia coli K-12, protein binding, transcription
1.10.10.10.65.1.1.1.23	1zrdB02	Escherichia coli K-12, transcription, protein binding, transcription activator activity, transcription repressor activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.24	1zreA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity
1.10.10.10.65.1.1.1.25	1zreB02	protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription activator activity, transcription repressor activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.26	1o3tA02	Catabolite gene activator, transcription repressor activity, transcription activator activity, transcription, protein binding, Escherichia coli K-12, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.27	1o3tB02	transcription activator activity, transcription repressor activity, Catabolite gene activator, Escherichia coli K-12, protein binding, transcription, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.28	1o3qA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity
1.10.10.10.65.1.1.1.29	1o3rA02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli K-12, transcription, protein binding, transcription activator activity, transcription repressor activity, Catabolite gene activator
1.10.10.10.65.1.1.1.30	1cgpA02	Catabolite gene activator, transcription activator activity, transcription repressor activity, protein binding, transcription, Escherichia coli K-12, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.31	1cgpB02	Escherichia coli K-12, protein binding, transcription, transcription activator activity, transcription repressor activity, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.32	1lb2A02	protein binding, transcription, Escherichia coli K-12, Catabolite gene activator, transcription repressor activity, transcription activator activity, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.33	2wc2A02	Escherichia coli O157:H7, Catabolite gene activator, CRP/FNR family transcriptional regulator, cyclic AMP receptor protein
1.10.10.10.65.1.1.1.34	2wc2B02	CRP/FNR family transcriptional regulator, cyclic AMP receptor protein, Escherichia coli O157:H7, Catabolite gene activator
1.10.10.10.65.1.1.1.35	1db7A02
1.10.10.10.65.1.1.1.36	1db8A02
1.10.10.10.65.1.1.1.37	1berA02
1.10.10.10.65.1.1.1.38	1berB02
1.10.10.10.65.1.1.1.39	1dbcA02
1.10.10.10.65.1.1.1.40	1dbcB02
1.10.10.10.65.1.1.1.41	3gapA02
1.10.10.10.65.1.1.1.42	3gapB02

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.10.10.65.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.10.10.65.1.1.1

Classification Lineage (1.10.10.10.65.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.10.10.65.1.1.1 (42)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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