# STOCKHOLM 1.0
#=GF ID 3.40.50.140/FF/000005
#=GF DE DNA topoisomerase
#=GF AC 3.40.50.140/FF/000005
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 91.605
#=GS B1L3G6/1-149      AC B1L3G6
#=GS B1L3G6/1-149      OS Candidatus Korarchaeum cryptofilum OPF8
#=GS B1L3G6/1-149      DE DNA topoisomerase 1
#=GS B1L3G6/1-149      DR ORG; Archaea; Candidatus Korarchaeota; Candidatus Korarchaeum; Candidatus Korarchaeum cryptofilum; 
#=GS A0A0D1C790/1-164  AC A0A0D1C790
#=GS A0A0D1C790/1-164  OS Ustilago maydis 521
#=GS A0A0D1C790/1-164  DE DNA topoisomerase
#=GS A0A0D1C790/1-164  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina; Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago; Ustilago maydis; 
#=GS E3KC11/52-224     AC E3KC11
#=GS E3KC11/52-224     OS Puccinia graminis f. sp. tritici CRL 75-36-700-3
#=GS E3KC11/52-224     DE DNA topoisomerase
#=GS E3KC11/52-224     DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia; Puccinia graminis; 
#=GS A9V1D2/1-170      AC A9V1D2
#=GS A9V1D2/1-170      OS Monosiga brevicollis
#=GS A9V1D2/1-170      DE Predicted protein
#=GS A9V1D2/1-170      DR ORG; Eukaryota; Choanoflagellida; Salpingoecidae; Monosiga; Monosiga brevicollis; 
#=GS A0DS57/5-175      AC A0DS57
#=GS A0DS57/5-175      OS Paramecium tetraurelia
#=GS A0DS57/5-175      DE DNA topoisomerase
#=GS A0DS57/5-175      DR ORG; Eukaryota; Ciliophora; Intramacronucleata; Oligohymenophorea; Peniculida; Parameciidae; Paramecium; Paramecium tetraurelia; 
#=GS A0A1D9Q6J0/1-167  AC A0A1D9Q6J0
#=GS A0A1D9Q6J0/1-167  OS Sclerotinia sclerotiorum 1980 UF-70
#=GS A0A1D9Q6J0/1-167  DE DNA topoisomerase
#=GS A0A1D9Q6J0/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes; Helotiales; Sclerotiniaceae; Sclerotinia; Sclerotinia sclerotiorum; 
#=GS A0A095C2T0/1-167  AC A0A095C2T0
#=GS A0A095C2T0/1-167  OS Cryptococcus gattii VGII R265
#=GS A0A095C2T0/1-167  DE DNA topoisomerase
#=GS A0A095C2T0/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGII; 
#=GS M9MAK8/798-969    AC M9MAK8
#=GS M9MAK8/798-969    OS Moesziomyces antarcticus T-34
#=GS M9MAK8/798-969    DE DNA topoisomerase III alpha
#=GS M9MAK8/798-969    DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina; Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces; Moesziomyces antarcticus; 
#=GS W3VT58/798-969    AC W3VT58
#=GS W3VT58/798-969    OS Moesziomyces aphidis DSM 70725
#=GS W3VT58/798-969    DE Uncharacterized protein
#=GS W3VT58/798-969    DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina; Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces; Moesziomyces aphidis; 
#=GS Q5KAU9/1-166      AC Q5KAU9
#=GS Q5KAU9/1-166      OS Cryptococcus neoformans var. neoformans JEC21
#=GS Q5KAU9/1-166      DE DNA topoisomerase
#=GS Q5KAU9/1-166      DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus neoformans species complex; Cryptococcus neoformans; Cryptococcus neoformans var. neoformans; 
#=GS A0A0D0WB63/1-167  AC A0A0D0WB63
#=GS A0A0D0WB63/1-167  OS Cryptococcus gattii EJB2
#=GS A0A0D0WB63/1-167  DE DNA topoisomerase
#=GS A0A0D0WB63/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGI; 
#=GS A0A0D0UN27/1-167  AC A0A0D0UN27
#=GS A0A0D0UN27/1-167  OS Cryptococcus gattii CA1280
#=GS A0A0D0UN27/1-167  DE DNA topoisomerase
#=GS A0A0D0UN27/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGIII; 
#=GS A0A0D0XTS2/1-167  AC A0A0D0XTS2
#=GS A0A0D0XTS2/1-167  OS Cryptococcus gattii VGIV IND107
#=GS A0A0D0XTS2/1-167  DE DNA topoisomerase
#=GS A0A0D0XTS2/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGIV; 
#=GS J9W0N6/1-166      AC J9W0N6
#=GS J9W0N6/1-166      OS Cryptococcus neoformans var. grubii H99
#=GS J9W0N6/1-166      DE DNA topoisomerase
#=GS J9W0N6/1-166      DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus neoformans species complex; Cryptococcus neoformans; Cryptococcus neoformans var. grubii; 
#=GS A7F4Y0/1-167      AC A7F4Y0
#=GS A7F4Y0/1-167      OS Sclerotinia sclerotiorum 1980 UF-70
#=GS A7F4Y0/1-167      DE DNA topoisomerase
#=GS A7F4Y0/1-167      DR ORG; Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes; Helotiales; Sclerotiniaceae; Sclerotinia; Sclerotinia sclerotiorum; 
#=GS A0A081CCC8/1-164  AC A0A081CCC8
#=GS A0A081CCC8/1-164  OS Moesziomyces antarcticus
#=GS A0A081CCC8/1-164  DE DNA topoisomerase
#=GS A0A081CCC8/1-164  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina; Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces; Moesziomyces antarcticus; 
#=GS E6R530/1-167      AC E6R530
#=GS E6R530/1-167      OS Cryptococcus gattii WM276
#=GS E6R530/1-167      DE DNA topoisomerase
#=GS E6R530/1-167      DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGI; 
#=GS A0A0D0VE76/1-167  AC A0A0D0VE76
#=GS A0A0D0VE76/1-167  OS Cryptococcus gattii VGII Ram5
#=GS A0A0D0VE76/1-167  DE DNA topoisomerase
#=GS A0A0D0VE76/1-167  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus gattii species complex; Cryptococcus gattii VGII; 
#=GS A0A226BCU0/1-166  AC A0A226BCU0
#=GS A0A226BCU0/1-166  OS Cryptococcus neoformans var. grubii Bt85
#=GS A0A226BCU0/1-166  DE DNA topoisomerase
#=GS A0A226BCU0/1-166  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus neoformans species complex; Cryptococcus neoformans; Cryptococcus neoformans var. grubii; 
#=GS A0A225XT02/1-166  AC A0A225XT02
#=GS A0A225XT02/1-166  OS Cryptococcus neoformans var. grubii c45
#=GS A0A225XT02/1-166  DE DNA topoisomerase
#=GS A0A225XT02/1-166  DR ORG; Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus; Cryptococcus neoformans species complex; Cryptococcus neoformans; Cryptococcus neoformans var. grubii; 
#=GF SQ 20
B1L3G6/1-149              ---------MTTLILTEKPNVAKRIASILSEGAKAKREGKVYY---YEF---------DTGGERYYVAPAAGHLLELDYPPGKWEYPSIVPPER----LVLKEIKG-----KREYL-KILEKLGKLSNRIIVATDLDSEGSSIALEIIKALNWEGKEI--LRMEFSSLTKEEIRSSFRDLKP-
A0A0D1C790/1-164          ---------MRILCVAEKPSIAKSIANILARGHASNRPGKDKFCRNYDFQYRMPG---VQGMVDMTMTSVRGHLTNTDFGPQHKAWFSCPPADL-FQAPVITNLSD-----DAKDIGTNLRLEARNADAVMIWTDCDREGEHIGSEIVAEVRKVRRNIRVMRARFSAIIDSQIHAACQNTVE-
E3KC11/52-224             YMVSCEFNNPQILCVAEKPSIARSVTEILSGNQFTTRQSPNRYTKNFDFHYRLPP---SPQLADFTVTSVLGHLTCTDFDADYKGWHNCDPFSL-FDAPIHRFVNP-----DHTGIERNLKAEARRADKLMIWTDCDREGEHIGSEIVSVCRAVKPGIIVLRARFSAIIPAQIHNACQNAGQ-
A9V1D2/1-170              -MAI-----TKVLMVAEKPTVAKGIAQILAPG-CRREATNCTYVGLWDFNIKIEG-----RPCNVKLTSVLGHLMTWEFKDAYRGWHSCAPQEL-FDAPLQHVVNDRPGETNCATIKTLLQKYARTCDWLIIATDNDREGENIGFEIIEVCRRVNRNLDCKRMKFSAVTPGEINGCLTRLVPP
A0DS57/5-175              -KTAIKFGKIRVLNVAEKPSVARSIATVLARD-HTIEETKSPYNKLFKFNFKLGE-----QDAEMWMTSVTGHLKNLKYPKQYQKWDKWDPLIILKDAEIENVISY-----EKRFLEENLQRFAKQCSQLILWLDCDREGENIAFEVLEVCKATNPQIKVHRAHFSAVTYVDIKKALENLQQP
A0A1D9Q6J0/1-167          -MA------PKILCVAEKPSIAKAVANHLAGGSAQASSTRNKYIKNYTFTFDFGG---QWGNCNAVMTSVSGHLTSLDVAPSHRSWTDPPPKSLFFEAPVIESIAE-----DKKVIAQNIESQARGARALFIWTDCDREGEHIGGEVRDQALKGNPRIEVKRARFSNIERAHVIQAAKHPVD-
A0A095C2T0/1-167          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGAHFTVTAVLGHLTSSDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
M9MAK8/798-969            -AAAPPVQTMRILCVAEKPSIAKSIAGILAGGHPSNRPGKDKFCRNYDFQYRMPG---VQGMVDMTVTSVRGHLTNADFGPEYKAWYSCSPADL-FTAPVLTNVSD-----DAKAIGLNLRNEARNADALMIWTDCDREGEHIGSEIVAEVRKVRRNIRVMRARFSAIIDSQIHAACQNTVE-
W3VT58/798-969            -AAAPPVETMRILCVAEKPSIAKSIAGILAGGHPSNRPGKDKFCRNYDFQYRMPG---VQGMVDMTVTSVRGHLTNADFGPEYKAWYSCSPADL-FTAPILTNVSD-----DAKSIGLNLRNEARNADALMIWTDCDREGEHIGSEIVAEVRKVRRNIRVMRARFSAIIDSQIHAACQNTVE-
Q5KAU9/1-166              ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDDDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQIEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAN--
A0A0D0WB63/1-167          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
A0A0D0UN27/1-167          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
A0A0D0XTS2/1-167          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGTNFTVTAVLGHLTSTDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
J9W0N6/1-166              ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDDDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAN--
A7F4Y0/1-167              -MA------PKILCVAEKPSIAKAVANHLAGGSAQASSTRNKYIKNYTFTFDFGG---QWGNCNAVMTSVSGHLTSLDVAPSHRSWTDPPPKSLFFEAPVIESIAE-----DKKVIAQNIESQARGARALFIWTDCDREGEHIGGEVRDQALKGNPRIEVKRARFSNIERAHVIQAAKHPVD-
A0A081CCC8/1-164          ---------MRILCVAEKPSIAKSIAGILAGGHPSNRPGKDKFCRNYDFQYRMPG---VQGMVDMTVTSVRGHLTNADFGPEYKAWYSCSPADL-FTAPIMTNLSD-----DAKAIGLNLRNEARNADALMIWTDCDREGEHIGSEIVAEVRKVRRNIRVMRARFSAIIDSQIHAACQNTVE-
E6R530/1-167              ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
A0A0D0VE76/1-167          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRNQYIRNYDFLYNLAPPLGNGRGAHFTVTAVLGHLTSSDFDEDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAND-
A0A226BCU0/1-166          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRCANFTVTAVLGHLTSSDFDDDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAN--
A0A225XT02/1-166          ---------MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDDDHRKWGSCDPFAL-FDAPVITFVDQ-----KLKTVESNLQAEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQAN--
#=GC scorecons            001000000566958899977986764696573234545544735576935443411122534544685839996437644465473654934606476744364400000536364367534874653767679697997697497544455555582649769967535685474544330
#=GC scorecons_70         ___________**_*********_**_**__*__________*___*_*_________________**_*_***___**___*__*____*__*___***___*______________**___**_*__*_*************_**__________*_*_*******____*__*_______
#=GC scorecons_80         ____________*_*********_*___*__*__________*___*_*__________________*_*_***___*_______*____*______*_____________________*___**____*_*_**_*****_**_*___________*___*__**_*____*__________
#=GC scorecons_90         ____________*_*****__*______*___________________*__________________*___***________________*___________________________________________*_*_**__*__*___________*___*__**______*__________
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