# STOCKHOLM 1.0
#=GF ID 3.80.10.10/FF/000424
#=GF DE Volume-regulated anion channel subunit LRRC8E
#=GF AC 3.80.10.10/FF/000424
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 82.897
#=GS Q6NSJ5/654-779      AC Q6NSJ5
#=GS Q6NSJ5/654-779      OS Homo sapiens
#=GS Q6NSJ5/654-779      DE Volume-regulated anion channel subunit LRRC8E
#=GS Q6NSJ5/654-779      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; 
#=GS Q6NSJ5/654-779      DR GO; GO:0005225; GO:0005515; GO:0005737; GO:0005886; GO:0005887; GO:0015810; GO:0034702; GO:0055085; GO:0071470; GO:0098656; 
#=GS Q66JT1/625-779      AC Q66JT1
#=GS Q66JT1/625-779      OS Mus musculus
#=GS Q66JT1/625-779      DE Volume-regulated anion channel subunit LRRC8E
#=GS Q66JT1/625-779      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Mus; Mus; Mus musculus; 
#=GS Q66JT1/625-779      DR GO; GO:0005225; GO:0005737; GO:0005886; GO:0005887; GO:0015810; GO:0034702; GO:0071470; GO:0098656; 
#=GS Q5DU41/626-793      AC Q5DU41
#=GS Q5DU41/626-793      OS Mus musculus
#=GS Q5DU41/626-793      DE Volume-regulated anion channel subunit LRRC8B
#=GS Q5DU41/626-793      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Myomorpha; Muridae; Murinae; Mus; Mus; Mus musculus; 
#=GS Q5DU41/626-793      DR GO; GO:0005737; GO:0005886; GO:0005887; GO:0034702; GO:0098656; 
#=GS W5NMI3/651-809      AC W5NMI3
#=GS W5NMI3/651-809      OS Lepisosteus oculatus
#=GS W5NMI3/651-809      DE Uncharacterized protein
#=GS W5NMI3/651-809      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus; Lepisosteus oculatus; 
#=GS B3DLX1/628-794      AC B3DLX1
#=GS B3DLX1/628-794      OS Xenopus tropicalis
#=GS B3DLX1/628-794      DE LOC100170560 protein
#=GS B3DLX1/628-794      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; 
#=GS A0A2U4B679/496-651  AC A0A2U4B679
#=GS A0A2U4B679/496-651  OS Tursiops truncatus
#=GS A0A2U4B679/496-651  DE volume-regulated anion channel subunit LRRC8E
#=GS A0A2U4B679/496-651  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Delphinidae; Tursiops; Tursiops truncatus; 
#=GS Q08BM6/663-826      AC Q08BM6
#=GS Q08BM6/663-826      OS Danio rerio
#=GS Q08BM6/663-826      DE Leucine rich repeat containing 8 family, member D
#=GS Q08BM6/663-826      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Otomorpha; Ostariophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio; Danio rerio; 
#=GS A0A2U3WSC3/622-778  AC A0A2U3WSC3
#=GS A0A2U3WSC3/622-778  OS Odobenus rosmarus divergens
#=GS A0A2U3WSC3/622-778  DE volume-regulated anion channel subunit LRRC8E isoform X1
#=GS A0A2U3WSC3/622-778  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus; Odobenus rosmarus; Odobenus rosmarus divergens; 
#=GS A0A091D7B2/626-797  AC A0A091D7B2
#=GS A0A091D7B2/626-797  OS Fukomys damarensis
#=GS A0A091D7B2/626-797  DE Leucine-rich repeat-containing protein 8B
#=GS A0A091D7B2/626-797  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Rodentia; Hystricomorpha; Bathyergidae; Fukomys; Fukomys damarensis; 
#=GS E2RNX3/623-774      AC E2RNX3
#=GS E2RNX3/623-774      OS Canis lupus familiaris
#=GS E2RNX3/623-774      DE Leucine rich repeat containing 8 VRAC subunit E
#=GS E2RNX3/623-774      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis; Canis lupus; Canis lupus familiaris; 
#=GS A0A2K5DTA5/625-779  AC A0A2K5DTA5
#=GS A0A2K5DTA5/625-779  OS Aotus nancymaae
#=GS A0A2K5DTA5/625-779  DE Uncharacterized protein
#=GS A0A2K5DTA5/625-779  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Aotidae; Aotus; Aotus nancymaae; 
#=GS A0A2K6A9Q8/627-780  AC A0A2K6A9Q8
#=GS A0A2K6A9Q8/627-780  OS Mandrillus leucophaeus
#=GS A0A2K6A9Q8/627-780  DE Uncharacterized protein
#=GS A0A2K6A9Q8/627-780  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Mandrillus; Mandrillus leucophaeus; 
#=GS A0A2K6TQX0/626-780  AC A0A2K6TQX0
#=GS A0A2K6TQX0/626-780  OS Saimiri boliviensis boliviensis
#=GS A0A2K6TQX0/626-780  DE Leucine rich repeat containing 8 VRAC subunit E
#=GS A0A2K6TQX0/626-780  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Saimiriinae; Saimiri; Saimiri boliviensis; Saimiri boliviensis boliviensis; 
#=GS A0A2K5RBY6/625-779  AC A0A2K5RBY6
#=GS A0A2K5RBY6/625-779  OS Cebus capucinus imitator
#=GS A0A2K5RBY6/625-779  DE Uncharacterized protein
#=GS A0A2K5RBY6/625-779  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Platyrrhini; Cebidae; Cebinae; Cebus; Cebus capucinus; Cebus capucinus imitator; 
#=GS H2QF75/654-779      AC H2QF75
#=GS H2QF75/654-779      OS Pan troglodytes
#=GS H2QF75/654-779      DE LRRC8E isoform 1
#=GS H2QF75/654-779      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; 
#=GS G7PYW8/626-780      AC G7PYW8
#=GS G7PYW8/626-780      OS Macaca fascicularis
#=GS G7PYW8/626-780      DE Leucine-rich repeat-containing protein 8E
#=GS G7PYW8/626-780      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; 
#=GS A0A2K5NE02/627-780  AC A0A2K5NE02
#=GS A0A2K5NE02/627-780  OS Cercocebus atys
#=GS A0A2K5NE02/627-780  DE Uncharacterized protein
#=GS A0A2K5NE02/627-780  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Cercocebus; Cercocebus atys; 
#=GS A0A0A0MVR8/627-780  AC A0A0A0MVR8
#=GS A0A0A0MVR8/627-780  OS Papio anubis
#=GS A0A0A0MVR8/627-780  DE Uncharacterized protein
#=GS A0A0A0MVR8/627-780  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Papio; Papio anubis; 
#=GS F7GRN6/627-780      AC F7GRN6
#=GS F7GRN6/627-780      OS Macaca mulatta
#=GS F7GRN6/627-780      DE Leucine-rich repeat-containing protein 8E
#=GS F7GRN6/627-780      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A2K6BP90/625-781  AC A0A2K6BP90
#=GS A0A2K6BP90/625-781  OS Macaca nemestrina
#=GS A0A2K6BP90/625-781  DE Uncharacterized protein
#=GS A0A2K6BP90/625-781  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca nemestrina; 
#=GS A0A2R8QGT7/665-819  AC A0A2R8QGT7
#=GS A0A2R8QGT7/665-819  OS Danio rerio
#=GS A0A2R8QGT7/665-819  DE Leucine-rich repeat-containing 8 VRAC subunit Db
#=GS A0A2R8QGT7/665-819  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Otomorpha; Ostariophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio; Danio rerio; 
#=GS A0A2U3ZSP4/542-698  AC A0A2U3ZSP4
#=GS A0A2U3ZSP4/542-698  OS Odobenus rosmarus divergens
#=GS A0A2U3ZSP4/542-698  DE volume-regulated anion channel subunit LRRC8E isoform X2
#=GS A0A2U3ZSP4/542-698  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus; Odobenus rosmarus; Odobenus rosmarus divergens; 
#=GS A0A2K5WKZ3/625-781  AC A0A2K5WKZ3
#=GS A0A2K5WKZ3/625-781  OS Macaca fascicularis
#=GS A0A2K5WKZ3/625-781  DE Uncharacterized protein
#=GS A0A2K5WKZ3/625-781  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca fascicularis; 
#=GF SQ 23
Q6NSJ5/654-779              -------------------------------SLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVED----------------
Q66JT1/625-779              ---FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALSRLELKGNRLETLPEELGDCKGLKKSGLLVEDT---------------
Q5DU41/626-793              IISFQHLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVA-----
W5NMI3/651-809              ---FQHLKRLTCLKLWHNKIISIPLSISHVKNLESLYFSHNKLESLPPPLFNLQKLRYLDVSHNTIAAIPLEIGFLQNLQHFAITGNKVEVLPKQLFKCTKLKTLFLGQNCISTIPEKICQLAQLTQLELKGNCLDRLPSQLGQCRLLRRTCLIVEDHLFDT-----------
B3DLX1/628-794              ------LQKLSILKLWHNSITKIPDHISKLANLEQLYISHNNIGDLPHDLFLCCKLRHLELSNNNIRSIPHIIRNLSNLKYFSVSYNRIETIPDELYFCQKLETLNLRHNNINTLSPNIGNLAQLSCLDVKENPIGSLPLELGSCQALKRNGLSVEDRLFETLPFDIRDKMTK
A0A2U4B679/496-651          ---FQHCRKLVTLRLWHNQIAYVPEHIRKLRGLEQLYLSHNKLETLPTQLGMCSGLRLLDISHNGLHSLPAELGLLQNLQHLAVSYNALELLPDELFFCRKLRTLLLGYNNLSQLSPQVGALGALSRLELKGNRLEALPEELGNCGGLKKSGLLVEDTL--------------
Q08BM6/663-826              ----QHLKRLNCLKLWHNKIISIPLSISHVKNLEFLYLSHNKLESLPTTLFNLLKLRYLDVSHNSIVVIPPEVGFLQNLQHFAITGNKVEVVPKQLFKCTKLRTLSLGHNCISSLPEKIGQLLQLTHLELKGNCLDRLPAQLGQCRLLRRNGLTVEDHLFDSLPLEVK-----
A0A2U3WSC3/622-778          --SFQHCRKLVTLRLWHNQIAYVPEHVRKLRGLEQLYLSHNKLETLPSQLGMCSGLRLLDISHNGLRSLPPELGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGYNHLSQLSPQVGALRALSRLELKGNRLEALPEELGNCAGLKKAGLLVEDTL--------------
A0A091D7B2/626-797          IISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLFLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLNNLQYFALTNNNIETLPDGLFQCKKLQCLLLGRNSLTELSPHVGELSNLTHLELTGNYLETLPPELEGCQALKRSCLLVEDSLLSTLPLPVTERLQ-
E2RNX3/623-774              ---FQHCRKLVTLKLWHNQIAYVPEHVRKLRGLEQLYLSHNKLETLPTQLGMCSGLRLLDISHNGLRSLPPELGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGYNHLSQLSSQVGALRALSRLELKGNRLEALPEELGNCVGLKKVGILV------------------
A0A2K5DTA5/625-779          --SFQHCRKLVMLRLWHNQIAYVPEHVRKLKSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALDALPDELFFCRKLRTLLLGDNQLTQLSPQVGALRALSRLELKGNRLETLPEELGNCGGLKKAGLLVED----------------
A0A2K6A9Q8/627-780          ----QHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT---------------
A0A2K6TQX0/626-780          ---FQHCRKLVTLRLWHNQIAYVPEHVRKLKSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALDALPDELFFCRKLRTLLLGDNQLTQLSPQVGALRALSRLELKGNRLEMLPEELGNCGGLKKAGLLVEDA---------------
A0A2K5RBY6/625-779          --SFQHCRKLVTLRLWHNQIAYVPEHVRKLKSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALDALPDELFFCRKLRTLLLGDNQLTQLSPQVGALRALSRLELKGNRLEMLPEELGNCGGLKKAGLLVED----------------
H2QF75/654-779              -------------------------------SLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVED----------------
G7PYW8/626-780              ---FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT---------------
A0A2K5NE02/627-780          ----QHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT---------------
A0A0A0MVR8/627-780          ----QHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT---------------
F7GRN6/627-780              ----QHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDT---------------
A0A2K6BP90/625-781          --SFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEVLPEELGNCGGLKKAGLLVEDTL--------------
A0A2R8QGT7/665-819          ----QHLKRLNCLKLWHNKIISIPLSISHVKNLEFLYLSHNKLESLPTTLFNLLKLRYLDVSHNSIVVIPPEVGFLQNLQHFAITGNKVEVVPKQLFKCTKLRTLSLGHNCISSLPEKIGQLLQLTHLELKGNCLDRLPAQLGQCRLLRRNGLTVEDHL--------------
A0A2U3ZSP4/542-698          --SFQHCRKLVTLRLWHNQIAYVPEHVRKLRGLEQLYLSHNKLETLPSQLGMCSGLRLLDISHNGLRSLPPELGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGYNHLSQLSPQVGALRALSRLELKGNRLEALPEELGNCAGLKKAGLLVEDTL--------------
A0A2K5WKZ3/625-781          --SFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPDELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEVLPEELGNCGGLKKAGLLVEDTL--------------
#=GC scorecons              00025534473375777747445734534545996987779678599459456459759869794645695766596898768664956857966984959967959849466487647749459659887894874994797494497746859882200000000000000
#=GC scorecons_70           _________*__*_****_*___*________**_*********_**__*__*__**_******_*__**_***_********_*_*__*_***_**_*_*****_**_*_*__**__**_*__**_******_**_**_***_*__***_**_***________________
#=GC scorecons_80           ________________________________**_****_*_**_**__*_____**_**_***_____*_*___*_****_*___*__*__*__**_*_**_**_**_*____*___**_*__*__******_*__**_***_*__**___*_***________________
#=GC scorecons_90           ________________________________**_**___*__*_**__*_____*__**_*_*_____*_____*_***__*___*__*__*__**_*_**__*_*__*____*______*__*__***_**_*__**__*__*__*____*_***________________
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