CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Low-specificity L-threonine aldolase

Enzyme Information

4.1.2.48
Low-specificity L-threonine aldolase.
based on mapping to UniProt P75823
(1) L-threonine = glycine + acetaldehyde. (2) L-allo-threonine = glycine + acetaldehyde.
-!- The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine. -!- The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine. -!- The enzyme can also catalyze the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis. -!- Different from EC 4.1.2.5 and EC 4.1.2.49.

UniProtKB Entries (1)

P75823
LTAE_ECOLI
Escherichia coli K-12
Low specificity L-threonine aldolase

PDB Structure

PDB 3WLX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure analysis of L-threonine aldolase from Escherichia coli unravels the low-specificity and thermostability
Qin, H.-M., Imai, F.L., Miyakawa, T., Kataoka, M., Okai, M., Ohtsuka, J., Hou, F., Nagata, K., Shimizu, S., Tanokura, M.
To be Published