CATH Classification

Domain Context

CATH Clusters

Superfamily alpha-amino acid ester hydrolase ( Helical cap domain)
Functional Family

Enzyme Information

3.1.1.84
Cocaine esterase.
based on mapping to UniProt Q9L9D7
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
-!- Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.

UniProtKB Entries (1)

Q9L9D7
COCE_RHOSM
Rhodococcus sp. MB1 'Bresler 1999'
Cocaine esterase

PDB Structure

PDB 3PUH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Narasimhan, D., Collins, G.T., Nance, M.R., Nichols, J., Edwald, E., Chan, J., Ko, M.C., Woods, J.H., Tesmer, J.J., Sunahara, R.K.
Mol.Pharmacol.