CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q6GHJ5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q6GHJ5
TRMD_STAAR
Staphylococcus aureus subsp. aureus MRSA252
TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB 3KY7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2.35 Angstrom resolution crystal structure of a putative tRNA (guanine-7-)-methyltransferase (trmD) from Staphylococcus aureus subsp. aureus MRSA252
Halavaty, A.S., Minasov, G., Winsor, J., Dubrovska, I., Shuvalova, L., See, R., Zoraghi, R., Reiner, N., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To be Published